Clinical application of acute Q fever -induced systemic capillary leak syndrome in a patient by using metagenomic next-generation sequencing: a case report and literature review

• Published in: BMC infectious diseases Vol. 25; no. 1; pp. 300 - 7
• Main Authors: Zhao, Junjie, Zhang, Weiwen, Luo, Jian, Fang, Honglong, Wang, Kaiyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.03.2025; BioMed Central; BMC
• Subjects: Abattoirs; Acidosis; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacterial infections; Blood circulation disorders; Blood pressure; Capillary Leak Syndrome - diagnosis; Capillary Leak Syndrome - etiology; Capillary Leak Syndrome - microbiology; Capillary Leak Syndrome - therapy; Cardiovascular system; Care and treatment; Case Report; Chlamydia; Complications and side effects; Coronaviruses; COVID-19; Coxiella burnetii; Coxiella burnetii - genetics; Coxiella burnetii - isolation & purification; Creatinine; Development and progression; Diagnosis; Disease; DNA sequencing; Doxycycline; Dyspnea; Edema; Effectiveness; Endocarditis; Etiology; Extravasation; Genetic aspects; Health aspects; Health services; Hematocrit; Hemoglobin; Hepatitis; High-Throughput Nucleotide Sequencing - methods; Humans; Hypotension; Infection; Infections; Infectious diseases; Influenza; Literature reviews; Lungs; Male; Metabolic acidosis; Metagenomic next-generation sequencing; Metagenomics; Metagenomics - methods; Methods; Middle Aged; Next-generation sequencing; Nucleotide sequencing; Pathogens; Patients; Penicillin; Pleural effusion; Pneumonia; Q fever; Q Fever - complications; Q Fever - diagnosis; Q Fever - drug therapy; Q Fever - microbiology; Rare diseases; Resuscitation; Rickettsial diseases; Serology; Systematic capillary leakage syndrome; Tazobactam; Tightness; Viral infections; Zoonoses; China; Metagenomic next-generation sequencing; Q fever; Coxiella burnetii; Systematic capillary leakage syndrome

Query fever (Q fever), a zoonotic disease, caused by Coxiella burnetii, is an infectious disease that has long been considered a rare and regionally restricted disease. It can be responsible for endocarditis and endovascular infections. Systemic capillary leak syndrome (SCLS), a rare disease of unkn...