Longitudinal study on Streptococcus pneumoniae , Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine

• Published in: Vaccine Vol. 33; no. 23; pp. 2662 - 2669
• Main Authors: Madhi, Shabir A, Izu, Alane, Nunes, Marta C, Violari, Avye, Cotton, Mark F, Jean-Philippe, Patrick, Klugman, Keith P, von Gottberg, Anne, van Niekerk, Nadia, Adrian, Peter V
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 28.05.2015; Elsevier Limited
• Subjects: Age; Allergy and Immunology; Antiretroviral agents; Carrier State - epidemiology; Carrier State - microbiology; Colonization; Confidence intervals; Disease; Female; Haemophilus Infections - epidemiology; Haemophilus Infections - microbiology; Haemophilus influenzae; Haemophilus influenzae - isolation & purification; Heptavalent Pneumococcal Conjugate Vaccine - administration & dosage; HIV; HIV exposure; HIV Infections - complications; Human immunodeficiency virus; Humans; Immunization; Infant; Infant, Newborn; Infants; Longitudinal Studies; Lymphocytes; Male; Meningitis; Nasopharynx - microbiology; Pneumococcal conjugate vaccine; Pneumococcal Infections - epidemiology; Pneumococcal Infections - microbiology; Pneumonia; Prevalence; Public health; Staphylococcal Infections - epidemiology; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - isolation & purification; Staphylococcus infections; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - isolation & purification; Studies; Vaccines; Pneumococcal conjugate vaccine; HIV; HIV exposure; Haemophilus influenzae; Staphylococcus aureus; Colonization; Streptococcus pneumoniae

Abstract Background Streptococcus pneumoniae , Haemophilus influenzae and Staphylococcus aureus are all potentially pathogenic, which frequently colonize the nasopharynx (NP) prior to causing disease. We studied bacterial NP-colonization in 321 HIV-infected and 243 HIV-uninfected children vaccinated...