Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

• Published in: Nature communications Vol. 11; no. 1; pp. 5666 - 14
• Main Authors: Hara-Chikuma, Mariko, Tanaka, Manami, Verkman, Alan S., Yasui, Masato
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.11.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 38/89; 631/154; 64/60; 692/4017; 692/4020/4021/1607; 82/1; 96/106; 96/109; 96/31; Animal models; Aquaporin 3; Aquaporins; Carbon tetrachloride; CCL4 protein; Cell activation; Epithelial cells; Epitopes; Fibrosis; Glycerol; Hepatocytes; Humanities and Social Sciences; Hydrogen peroxide; Injury prevention; Liver; Macrophages; Monoclonal antibodies; multidisciplinary; NF-κB protein; Oxidative stress; Science; Science (multidisciplinary)

Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H 2 O 2 ) that is expressed in various epithelial cells and in macrophages. Here, we developed an anti-AQP3 monoclonal antibody (mAb) that inhibited AQP3-facilitated H 2 O 2 and glycerol transport, and prevented liver inju...