Development and validation of language and visuospatial composite scores in ADNI

Introduction Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods We used item response theory to derive composite measures for language (ADNI‐Lan) and visuospatial functioning (ADNI‐VS) from the cognitive battery administered i...

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Published inAlzheimer's & dementia : translational research & clinical interventions Vol. 6; no. 1; pp. e12072 - n/a
Main Authors Choi, Seo‐Eun, Mukherjee, Shubhabrata, Gibbons, Laura E., Sanders, R. Elizabeth, Jones, Richard N., Tommet, Douglas, Mez, Jesse, Trittschuh, Emily H., Saykin, Andrew, Lamar, Melissa, Rabin, Laura, Foldi, Nancy S., Sikkes, Sietske, Jutten, Roos J., Grandoit, Evan, Mac Donald, Christine, Risacher, Shannon, Groot, Colin, Ossenkoppele, Rik, Crane, Paul K.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 2020
John Wiley and Sons Inc
Wiley
Subjects
Alzheimer's disease
Alzheimer's Disease Neuroimaging Initiative
Animal cognition
Annan medicin och hälsovetenskap
Brain
Clinical Medicine
cognition
Cognitive ability
Dementia
Enrollments
Gerontologi, medicinsk/hälsovetenskaplig inriktning
Gerontology, specializing in Medical and Health Sciences
Klinisk medicin
Language
longitudinal analysis
Magnetic resonance imaging
Medical and Health Sciences
Medical imaging
Medicin och hälsovetenskap
Memory
Neuroimaging
Neurologi
Neurology
Neuropsychology
Other Medical Sciences
psychometrics
Standard scores
visuospatial functioning
Alzheimer's Disease Neuroimaging Initiative
magnetic resonance imaging
cognition
longitudinal analysis
psychometrics
language
visuospatial functioning
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Summary:Introduction Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods We used item response theory to derive composite measures for language (ADNI‐Lan) and visuospatial functioning (ADNI‐VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results ADNI‐Lan and ADNI‐VS were able to detect change over time and predict conversion from MCI to AD. They were associated with most of the pre‐specified magnetic resonance imaging measures. ADNI‐Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion ADNI‐Lan and ADNI‐VS may be useful composites for language and visuospatial functioning in ADNI.
Bibliography:Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at
http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
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Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
ISSN:2352-8737
2352-8737
DOI:10.1002/trc2.12072