B7家族共刺激分子在血液系统恶性肿瘤中的研究进展

T细胞免疫需要双信号系统进行活化,其中B7/CD28分子介导的协同刺激信号发挥了必不可少的作用.目前已发现10个B7家族成员[1-2]（表1）.B7分子在淋巴和非淋巴器官均有表达,不同成员与相应受体结合介导正性或负性的免疫调控信号,决定了T细胞的活化增殖或者转变为无反应状态甚至凋亡,进而参与抗肿瘤免疫.另一方面,一些负性共刺激分子也通过非免疫调控作用直接参与肿瘤的形成[3]....

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Published in中华血液学杂志 Vol. 36; no. 7; pp. 626 - 630
Main Author 张巍 董菲 克晓燕
Format Journal Article
LanguageChinese
Published 100191,北京大学第三医院血液科 2015
Subjects
B7家族
CD28分子
T细胞免疫
信号系统
免疫调控作用
协同刺激信号
血液系统恶性肿瘤
负性共刺激分子
@@
Online AccessGet full text
ISSN0253-2727
DOI10.3760/cma.j.issn.0253-2727.2015.07.023

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Abstract T细胞免疫需要双信号系统进行活化,其中B7/CD28分子介导的协同刺激信号发挥了必不可少的作用.目前已发现10个B7家族成员[1-2]（表1）.B7分子在淋巴和非淋巴器官均有表达,不同成员与相应受体结合介导正性或负性的免疫调控信号,决定了T细胞的活化增殖或者转变为无反应状态甚至凋亡,进而参与抗肿瘤免疫.另一方面,一些负性共刺激分子也通过非免疫调控作用直接参与肿瘤的形成[3].
AbstractList @@
T细胞免疫需要双信号系统进行活化,其中B7/CD28分子介导的协同刺激信号发挥了必不可少的作用.目前已发现10个B7家族成员[1-2]（表1）.B7分子在淋巴和非淋巴器官均有表达,不同成员与相应受体结合介导正性或负性的免疫调控信号,决定了T细胞的活化增殖或者转变为无反应状态甚至凋亡,进而参与抗肿瘤免疫.另一方面,一些负性共刺激分子也通过非免疫调控作用直接参与肿瘤的形成[3].
Author 张巍 董菲 克晓燕
AuthorAffiliation 北京大学第三医院血液科,100191
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Notes Zhang Wei, Dong Fei, Ke Xiaoyan（Ke Xiaoyan, Department of Hematology, Peking University Third Hospital, Beijing 100191, China.）
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SubjectTerms B7家族
CD28分子
T细胞免疫
信号系统
免疫调控作用
协同刺激信号
血液系统恶性肿瘤
负性共刺激分子
Title B7家族共刺激分子在血液系统恶性肿瘤中的研究进展
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