Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

• Published in: Genetics (Austin) Vol. 181; no. 2; pp. 525 - 541
• Main Authors: Simon, Anne F, Daniels, Richard, Romero-Calderon, Rafael, Grygoruk, Anna, Chang, Hui-Yun, Najibi, Rod, Shamouelian, David, Salazar, Evelyn, Solomon, Mordecai, Ackerson, Larry C, Maidment, Nigel T, DiAntonio, Aaron, Krantz, David E
• Format: Journal Article
• Language: English
• Published: United States Genetics Soc America 01.02.2009; Genetics Society of America
• Subjects: adult insects; Adults; Amines; Animals; Behavior; Behavior, Animal; Behavior, Animal - drug effects; Cocaine; Cocaine - pharmacology; dopamine; Dopamine - metabolism; Drosophila melanogaster; Drosophila melanogaster - drug effects; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Drug abuse; drug effects; electrophysiology; Environmental health; Female; Fertility; Genes, Insect; Genetics; glutamine; Grants; imagos; Infertility; Infertility - genetics; Infertility - metabolism; insect behavior; Investigations; Larvae; locomotion; Male; metabolism; motor neurons; Mutants; Mutation; Neurological disorders; Neuromuscular Junction; Neuromuscular Junction - metabolism; neuromuscular junctions; neurophysiology; Octopamine; Octopamine - metabolism; Oogenesis; Oogenesis - genetics; pharmacology; Phenotype; Photobiology; phototaxis; Population density; serotonin; Serotonin - metabolism; transporters; Vesicular Monoamine Transport Proteins; Vesicular Monoamine Transport Proteins - genetics; Vesicular Monoamine Transport Proteins - metabolism; vesicular monoamine transporter

Physiologic and pathogenic changes in amine release induce dramatic behavioral changes, but the underlying cellular mechanisms remain unclear. To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the...