Superior immunogenicity of mRNA over adenoviral vectored COVID-19 vaccines reflects B cell dynamics independent of anti-vector immunity: Implications for future pandemic vaccines

• Published in: Vaccine Vol. 41; no. 48; pp. 7192 - 7200
• Main Authors: Liu, Yi, Sánchez-Ovando, Stephany, Carolan, Louise, Dowson, Leslie, Khvorov, Arseniy, Jessica Hadiprodjo, A., Tseng, Yeu Yang, Delahunty, Catherine, Khatami, Ameneh, Macnish, Marion, Dougherty, Sonia, Hagenauer, Michelle, Riley, Kathryn E., Jadhav, Ajay, Harvey, Joanne, Kaiser, Marti, Mathew, Suja, Hodgson, David, Leung, Vivian, Subbarao, Kanta, Cheng, Allen C., Macartney, Kristine, Koirala, Archana, Marshall, Helen, Clark, Julia, Blyth, Christopher C., Wark, Peter, Kucharski, Adam J., Sullivan, Sheena G., Fox, Annette
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 22.11.2023; Elsevier Limited
• Subjects: Adenoviruses; Allergy and Immunology; Antibodies; Antibodies, Viral; Antibody; B cells; B-lymphocytes; BNT162 Vaccine; ChAdOx1 nCoV-19; COVID-19; COVID-19 - prevention & control; COVID-19 infection; COVID-19 Vaccines; Disease transmission; Fluorescence; health services; Hospitals; Human mastadenovirus C; Humans; Immunity; Immunogenicity; Immunoglobulin G; Immunological memory; Infections; Influenza; Lymphocytes B; Medical personnel; memory; Memory cells; Monkeys & apes; mRNA; mRNA vaccines; Neutralization; neutralization tests; pandemic; Pandemics; Pandemics - prevention & control; Performance evaluation; Protein folding; Proteins; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; vaccination; Vaccine; Vaccines; Vector; Viral diseases; Viral Vaccines; Australia; COVID-19; SARS-CoV-2; Antibody; Vaccine; mRNA; B cells; Vector

•vaccine induced higher Surrogate neutralizing antibody and RBD-targeted B cell responses were greater after mRNA compared to vector vaccine.•Although vector vaccine boosted antibodies against human Adenovirus, those titres did not correlate with anti-spike titres.•Further work is needed to improve...