Increased Excitability of Layer 2 Cortical Pyramidal Neurons in the Supplementary Motor Cortex Underlies High Cocaine-Seeking Behaviors

• Published in: Biological psychiatry (1969) Vol. 94; no. 11; pp. 875 - 887
• Main Authors: Huang, Donald, Ma, Yao-Ying
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2023
• Subjects: Animals; Cocaine; Cortical pyramidal neurons; Drug seeking; Drug-Seeking Behavior; Intrinsic excitability; Motor Cortex; Prefrontal Cortex - physiology; Psychiatric/Mental Health; Pyramidal Cells - physiology; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Intrinsic excitability; Cocaine; Drug seeking; Motor cortex; Cortical pyramidal neurons

Most efforts in addiction research have focused on the involvement of the medial prefrontal cortex, including the infralimbic, prelimbic, and anterior cingulate cortical areas, in cocaine-seeking behaviors. However, no effective prevention or treatment for drug relapse is available. We focused inste...