Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 157; no. 3; pp. 793 - 806.e14
• Main Authors: Yan, Jiong, Tung, Hung-Chun, Li, Sihan, Niu, Yongdong, Garbacz, Wojciech G., Lu, Peipei, Bi, Yuhan, Li, Yanping, He, Jinhan, Xu, Meishu, Ren, Songrong, Monga, Satdarshan P., Schwabe, Robert F., Yang, Da, Xie, Wen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019
• Subjects: Animals; Basic Helix-Loop-Helix Transcription Factors - agonists; Basic Helix-Loop-Helix Transcription Factors - deficiency; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; beta Catenin - metabolism; Cell Proliferation; Cell Type-Specific Effect; Cells, Cultured; Cellular Senescence - drug effects; Chemical and Drug Induced Liver Injury - genetics; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Gene Expression Regulation; Gene Regulation; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Indoles - pharmacology; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Experimental - genetics; Liver Cirrhosis, Experimental - metabolism; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Receptors, Aryl Hydrocarbon - agonists; Receptors, Aryl Hydrocarbon - deficiency; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Signal Transduction; Smad3 Protein - metabolism; Thiazoles - pharmacology; Xenobiotic Receptor; AST; Signal Transduction; Xenobiotic Receptor; KO; Cell Type-Specific Effect; TCDD; ALT; ARNT; AhR; mRNA; XRE; ChIP; ECM; Gene Regulation; α-SMA; TGF; RNA-seq; DRE; HSC; FICZ; ITE; Lrat; PCR; CUL4B

The role of aryl hydrocarbon receptor (AhR) in liver fibrosis is controversial because loss and gain of AhR activity both lead to liver fibrosis. The goal of this study was to investigate how the expression of AhR by different liver cell types, hepatic stellate cells (HSCs) in particular, affects li...