Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice - Yan, Jiong; Tung, Hung-Chun; Li, Sihan; Niu, Yongdong; Garbacz, Wojciech G.; Lu, Peipei; Bi, Yuhan; Li, Yanping; He, Jinhan; Xu, Meishu; Ren, Songrong; Monga, Satdarshan P.; et al. (Gastroenterology (New York, N.Y. 1943), 2019)
Keywords: Animals; Basic Helix-Loop-Helix Transcription Factors - agonists; Basic Helix-Loop-Helix Transcription Factors - deficiency; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; beta Catenin - metabolism; Cell Proliferation; Cell Type-Specific Effect; Cells, Cultured; Cellular Senescence - drug effects; Chemical and Drug Induced Liver Injury - genetics; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Gene Expression Regulation; Gene Regulation; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Indoles - pharmacology; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Experimental - genetics; Liver Cirrhosis, Experimental - metabolism; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Receptors, Aryl Hydrocarbon - agonists; Receptors, Aryl Hydrocarbon - deficiency; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Signal Transduction; Smad3 Protein - metabolism; Thiazoles - pharmacology; Xenobiotic Receptor; AST; Signal Transduction; Xenobiotic Receptor; KO; Cell Type-Specific Effect; TCDD; ALT; ARNT; AhR; mRNA; XRE; ChIP; ECM; Gene Regulation; α-SMA; TGF; RNA-seq; DRE; HSC; FICZ; ITE; Lrat; PCR; CUL4B