Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition - Wada, Masami; Tamura, Atsushi; Takahashi, Nobuyuki; Tsukita, Sachiko (Gastroenterology (New York, N.Y. 1943), 2013)
Keywords: Amino Acids - pharmacokinetics; Animals; Biological Transport; Cell Membrane - metabolism; Cell Membrane - ultrastructure; Cell Membrane Permeability; Claudin-15; Claudin-2; Claudin-2 - genetics; Claudin-2 - metabolism; Claudins - genetics; Claudins - metabolism; Disease Models, Animal; Epithelial Cells - metabolism; Epithelial Cells - ultrastructure; Fats - pharmacokinetics; Gastroenterology and Hepatology; Glucose - pharmacokinetics; Immunoblotting; Intestinal Absorption - physiology; Intestinal Mucosa - metabolism; Intestinal Mucosa - ultrastructure; Intestine, Small - metabolism; Intestine, Small - ultrastructure; Malnutrition - genetics; Malnutrition - metabolism; Malnutrition - mortality; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Fluorescence; Na+-Dependent Transporter; Nutrient Malabsorption; Phenotype; Real-Time Polymerase Chain Reaction; Sodium - metabolism; Tight Junctions - genetics; Tight Junctions - metabolism; FFA; Claudin-15; pnd; qRT-PCR; Nutrient Malabsorption; DKO; mRNA; Claudin-2; Na+-Dependent Transporter; pAb; DHet; TG; Isc; OGTT; WT; triglyceride; oral glucose tolerance test; double-heterogenous; short-circuit current; Na +-Dependent Transporter; messenger RNA; polyclonal antibody; postnatal day; double-knockout; quantitative real-time reverse-transcription polymerase chain reaction; free fatty acid; wild type