Beneficial and adverse effects of antipsychotic medication on cognitive flexibility are related to COMT genotype in first episode psychosis

• Published in: Schizophrenia research Vol. 202; pp. 212 - 216
• Main Authors: Nelson, Courtney L.M., Amsbaugh, Hayley M., Reilly, James L., Rosen, Cherise, Marvin, Robert W., Ragozzino, Michael E., Bishop, Jeffrey R., Sweeney, John A., Hill, S. Kristian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018
• Subjects: Antipsychotic; COMT; PCET; Psychiatric/Mental Health; Psychosis; Psychosis; Antipsychotic; COMT; PCET

This study evaluated the ability to flexibly shift cognitive set and to consistently maintain a new response preference using the Penn Conditional Exclusion Test (PCET). The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val...