Psychomotor retardation is a scar of past depressive episodes, revealed by simple cognitive tests

• Published in: European neuropsychopharmacology Vol. 24; no. 10; pp. 1630 - 1640
• Main Authors: Gorwood, P, Richard-Devantoy, S, Baylé, F, Cléry-Melun, M.L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2014
• Subjects: Acetamides - therapeutic use; Antidepressive Agents - therapeutic use; Attention - drug effects; Attention - physiology; Cognition; Cognition - drug effects; Cognition - physiology; Depressive Disorder - drug therapy; Depressive Disorder - physiopathology; Depressive Disorder - psychology; Female; Follow-Up Studies; Humans; Internal Medicine; Major depressive disorder; Male; Middle Aged; Neuropsychological Tests; Neurotoxic; Psychiatry; Psychomotor Performance - drug effects; Psychomotor Performance - physiology; Psychomotor retardation; Recurrence; Scar; Severity of Illness Index; Recurrence; Cognition; Neurotoxic; Psychomotor retardation; Scar; Major depressive disorder

Abstract The cumulative duration of depressive episodes, and their repetition, has a detrimental effect on depression recurrence rates and the chances of antidepressant response, and even increases the risk of dementia, raising the possibility that depressive episodes could be neurotoxic. Psychomoto...