Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

• Published in: The American journal of pathology Vol. 188; no. 5; pp. 1183 - 1194
• Main Authors: Alexeev, Erica E., Lanis, Jordi M., Kao, Daniel J., Campbell, Eric L., Kelly, Caleb J., Battista, Kayla D., Gerich, Mark E., Jenkins, Brittany R., Walk, Seth T., Kominsky, Douglas J., Colgan, Sean P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2018; American Society for Investigative Pathology
• Subjects: Animals; Cell Line; Colitis - chemically induced; Colitis - metabolism; Dextran Sulfate; Disease Models, Animal; Homeostasis - physiology; Humans; Indoles - metabolism; Intestinal Mucosa - metabolism; Metabolomics; Mice; Microbiota - physiology; Receptors, Interleukin-10 - metabolism

Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The specific constituents of the microbiota that contribute to mucosal disease are not well defined. The authors sought to define microbial components...