SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

• Published in: Nature immunology Vol. 21; no. 11; pp. 1327 - 1335
• Main Authors: Winkler, Emma S., Bailey, Adam L., Kafai, Natasha M., Nair, Sharmila, McCune, Broc T., Yu, Jinsheng, Fox, Julie M., Chen, Rita E., Earnest, James T., Keeler, Shamus P., Ritter, Jon H., Kang, Liang-I, Dort, Sarah, Robichaud, Annette, Head, Richard, Holtzman, Michael J., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2020; Nature Publishing Group
• Subjects: 631/250/2499; 631/326/596/4130; ACE2; Angiotensin; Angiotensin converting enzyme; Angiotensin I; Angiotensin-Converting Enzyme 2; Animal models; Animals; Antiviral drugs; Betacoronavirus - immunology; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell activation; Chlorocebus aethiops; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronaviruses; COVID-19; Cytokeratin; Development and progression; Disease Models, Animal; Female; Gene expression; Genetic aspects; Health aspects; Humans; Immune response; Immunity, Innate - immunology; Immunology; Infections; Infectious Diseases; Inflammation; Innate immunity; Inoculation; Interferon; Interferon Type I - immunology; Interferon-gamma - immunology; Keratin-18 - genetics; Leukocytes (neutrophilic); Leukocytes - immunology; Lung diseases; Lymphocyte Activation - immunology; Lymphocytes T; Male; Mice; Mice, Transgenic; Monocytes; Monocytes - immunology; Neutrophil Infiltration - immunology; Neutrophils - immunology; NF-kappa B - immunology; Pandemics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Phenotypes; Pneumonia - genetics; Pneumonia - pathology; Pneumonia - virology; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Promoter Regions, Genetic - genetics; Respiratory function; Respiratory tract infections; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; T-Lymphocytes - immunology; Transgenic animals; Transgenic mice; Vero Cells; Viral infections; Virus Replication - immunology; United States

Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease phenotypes seen in humans who have been hospitalized. Here, we evaluate transgenic mice expressing the human angiotensin I-converting...