Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 164; no. 2; pp. 272 - 288
• Main Authors: Nagata, Naoyoshi, Takeuchi, Tadashi, Masuoka, Hiroaki, Aoki, Ryo, Ishikane, Masahiro, Iwamoto, Noriko, Sugiyama, Masaya, Suda, Wataru, Nakanishi, Yumiko, Terada-Hirashima, Junko, Kimura, Moto, Nishijima, Tomohiko, Inooka, Hiroshi, Miyoshi-Akiyama, Tohru, Kojima, Yasushi, Shimokawa, Chikako, Hisaeda, Hajime, Zhang, Fen, Yeoh, Yun Kit, Ng, Siew C., Uemura, Naomi, Itoi, Takao, Mizokami, Masashi, Kawai, Takashi, Sugiyama, Haruhito, Ohmagari, Norio, Ohno, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023; by the AGA Institute
• Subjects: COVID-19; Cross-Sectional Studies; Cytokine Storm; Cytokines; Fecal Metabolome; Feces - chemistry; Gastrointestinal Microbiome - genetics; Gut Microbiome; Gut-Lung Axis; Humans; Immunity; SARS-CoV-2; Vitamin B 6 - analysis; IL; KO; Gut-Lung Axis; Spo2; PPI; DM; IBD; Gut Microbiome; SCFA; bp; AUC; RA; Cytokine Storm; 4D; Fecal Metabolome; FDR; KEGG; WBC; BCAA; BMI; COPD; NCGM

We investigate interrelationships between gut microbes, metabolites, and cytokines that characterize COVID-19 and its complications, and we validate the results with follow-up, the Japanese 4D (Disease, Drug, Diet, Daily Life) microbiome cohort, and non-Japanese data sets. We performed shotgun metag...