Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis

• Published in: Journal of autoimmunity Vol. 78; pp. 101 - 110
• Main Authors: Wasén, Caroline, Turkkila, Minna, Bossios, Apostolos, Erlandsson, Malin, Andersson, Karin M., Ekerljung, Linda, Malmhäll, Carina, Brisslert, Mikael, Töyrä Silfverswärd, Sofia, Lundbäck, Bo, Bokarewa, Maria I.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Allergy and Immunology; alleviates experimental arthritis; Animals; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; association; Autoimmunitet och inflammation; Autoimmunity and Inflammation; Biomarkers; Bone Marrow - drug effects; Bone Marrow - metabolism; Case-Control Studies; CD8(+) T cells; Child; Child, Preschool; chronic viral-infection; co-stimulation; Disease Models, Animal; disease-activity; exhaustion; expression; Female; Humans; il-7 receptor; immune-responses; Immunologi inom det medicinska området; Immunology; Immunology in the Medical Area; Immunophenotyping; inhibition; Inhibitor of Apoptosis Proteins - biosynthesis; Inhibitor of Apoptosis Proteins - blood; Interleukin-7 receptor; lnterleukin-7; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Male; Mice; Mice, Knockout; Middle Aged; Nicotine - pharmacology; Phenotype; Programmed cell death 1; Programmed Cell Death 1 Receptor - deficiency; Programmed Cell Death 1 Receptor - metabolism; Rheumatoid arthritis; Smoking; Survivin; T-Lymphocytes, Cytotoxic - drug effects; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - metabolism; Young Adult; Interleukin-7 receptor; CD8+ T cells; Survivin; Rheumatoid arthritis; Programmed cell death 1; Smoking; CD8 + T cells; CD8(+) T cells

CD8+ T cells have an emerging role in RA. Resent research indicates a causal relationship between the non-exhausted state of CD8+ T cells, defined by lost function of PD-1, and development of arthritis. We investigated how smoking contributes to the non-exhausted phenotype of CD8+ T cells and cause...