The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions

• Published in: Human pathology Vol. 46; no. 1; pp. 1 - 8
• Main Authors: Davidson, Ben, Holth, Arild, Hellesylt, Ellen, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Tropé, Claes, Nesland, Jahn M., Thiery, Jean Paul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015; Elsevier Limited
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents - therapeutic use; Biomarkers, Tumor - analysis; Biopsy; Cancer therapies; Chemoresistance; Chemotherapy; Chi-Square Distribution; Confidence intervals; Drug Resistance, Neoplasm; Effusion; Epithelial-Mesenchymal Transition; Extracellular matrix; Female; Gene expression; Homeodomain Proteins - analysis; Humans; Immunohistochemistry; Laboratories; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous - chemistry; Neoplasms, Cystic, Mucinous, and Serous - drug therapy; Neoplasms, Cystic, Mucinous, and Serous - mortality; Neoplasms, Cystic, Mucinous, and Serous - pathology; Neoplastic Stem Cells - chemistry; Neoplastic Stem Cells - metabolism; Neural Cell Adhesion Molecules - analysis; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - chemistry; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; P-Selectin - analysis; Pathology; Predictive Value of Tests; Proportional Hazards Models; Protein expression; Proteins; Risk Factors; Statistical analysis; Studies; Survival; Time Factors; Transcription factors; Transcription Factors - analysis; Treatment Outcome; Tumors; Vimentin - analysis; Zinc Finger E-box-Binding Homeobox 1; Epithelial-mesenchymal transition; Ovarian carcinoma; Effusion; Survival; Chemoresistance

We recently identified gene signatures that allow classification of ovarian carcinoma into 5 distinct clinically relevant groups. In the present study, we investigated the clinical role of 10 protein products of the discriminating genes, with focus on epithelial-mesenchymal transition and stem cell...