Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome

Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 ref...

Full description

Saved in:
Bibliographic Details
Published inNature neuroscience Vol. 21; no. 8; pp. 1126 - 1136
Main Authors Girdhar, Kiran, Hoffman, Gabriel E., Jiang, Yan, Brown, Leanne, Kundakovic, Marija, Hauberg, Mads E., Francoeur, Nancy J., Wang, Ying-chih, Shah, Hardik, Kavanagh, David H., Zharovsky, Elizabeth, Jacobov, Rivka, Wiseman, Jennifer R., Park, Royce, Johnson, Jessica S., Kassim, Bibi S., Sloofman, Laura, Mattei, Eugenio, Weng, Zhiping, Sieberts, Solveig K., Peters, Mette A., Harris, Brent T., Lipska, Barbara K., Sklar, Pamela, Roussos, Panos, Akbarian, Schahram
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.08.2018
Nature Publishing Group
Subjects
45
45/15
45/23
631/114/1314
692/699/476/1799
Alzheimer Disease - genetics
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain Mapping
Brain research
Chromatin
Chromatin - genetics
Corporate sponsorship
Cortex (cingulate)
Depletion
Depression - genetics
Depression - pathology
Educational Status
Enhancers
Epigenesis, Genetic - genetics
Epigenetic inheritance
Frontal lobe
Frontal Lobe - metabolism
Frontal Lobe - pathology
Frontal lobes
Gene mapping
Genetic aspects
Genetic Predisposition to Disease - genetics
Genetic Variation
Genome-Wide Association Study
Gyrus Cinguli - pathology
Health aspects
Histones
Histones - genetics
Humans
Landscape
Legal liability
Liability
Medical schools
Mental disorders
Methylation
Molecular neurobiology
Neurobiology
Neurogenetics
Neurons
Neurosciences
Neurosis
Neurotic Disorders - genetics
Neurotic Disorders - pathology
Physiological aspects
Post-translational modifications
Prefrontal cortex
Prefrontal Cortex - pathology
Psychosis
Quantitative genetics
Quantitative trait loci
Resource
Risk
Risk factors
Schizophrenia
Schizophrenia - genetics
Schizophrenia - metabolism
Online AccessGet full text

Cover

Abstract Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe. This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.
AbstractList Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe.Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe.
Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe.
Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe. This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.
Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly characterized. We have generated for two cortical areas implicated in psychosis, the dorsolateral prefrontal cortex and anterior cingulate cortex, 157 reference maps from neuronal, neuron-depleted and bulk tissue chromatin for two histone marks associated with active promoters and enhancers, H3-trimethyl-Lys4 (H3K4me3) and H3-acetyl-Lys27 (H3K27ac). Differences between neuronal and neuron-depleted chromatin states were the major axis of variation in histone modification profiles, followed by substantial variability across subjects and cortical areas. Thousands of significant histone quantitative trait loci were identified in neuronal and neuron-depleted samples. Risk variants for schizophrenia, depressive symptoms and neuroticism were significantly over-represented in neuronal H3K4me3 and H3K27ac landscapes. Our Resource, sponsored by PsychENCODE and CommonMind, highlights the critical role of cell-type-specific signatures at regulatory and disease-associated noncoding sequences in the human frontal lobe. This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.
Audience Academic
Author Kundakovic, Marija
Kavanagh, David H.
Zharovsky, Elizabeth
Brown, Leanne
Hauberg, Mads E.
Akbarian, Schahram
Girdhar, Kiran
Johnson, Jessica S.
Jiang, Yan
Wiseman, Jennifer R.
Lipska, Barbara K.
Mattei, Eugenio
Hoffman, Gabriel E.
Sloofman, Laura
Park, Royce
Harris, Brent T.
Roussos, Panos
Wang, Ying-chih
Kassim, Bibi S.
Weng, Zhiping
Jacobov, Rivka
Sieberts, Solveig K.
Peters, Mette A.
Shah, Hardik
Sklar, Pamela
Francoeur, Nancy J.
Author_xml – sequence: 1
  givenname: Kiran
  surname: Girdhar
  fullname: Girdhar, Kiran
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 2
  givenname: Gabriel E.
  orcidid: 0000-0002-0957-0224
  surname: Hoffman
  fullname: Hoffman, Gabriel E.
  email: gabriel.hoffman@mssm.edu
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 3
  givenname: Yan
  surname: Jiang
  fullname: Jiang, Yan
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 4
  givenname: Leanne
  surname: Brown
  fullname: Brown, Leanne
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 5
  givenname: Marija
  surname: Kundakovic
  fullname: Kundakovic, Marija
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, Department of Biological Sciences, Fordham University
– sequence: 6
  givenname: Mads E.
  orcidid: 0000-0003-4873-2764
  surname: Hauberg
  fullname: Hauberg, Mads E.
  organization: iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Department of Biomedicine, Aarhus University
– sequence: 7
  givenname: Nancy J.
  surname: Francoeur
  fullname: Francoeur, Nancy J.
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 8
  givenname: Ying-chih
  surname: Wang
  fullname: Wang, Ying-chih
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 9
  givenname: Hardik
  surname: Shah
  fullname: Shah, Hardik
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 10
  givenname: David H.
  surname: Kavanagh
  fullname: Kavanagh, David H.
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 11
  givenname: Elizabeth
  surname: Zharovsky
  fullname: Zharovsky, Elizabeth
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 12
  givenname: Rivka
  surname: Jacobov
  fullname: Jacobov, Rivka
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 13
  givenname: Jennifer R.
  surname: Wiseman
  fullname: Wiseman, Jennifer R.
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 14
  givenname: Royce
  surname: Park
  fullname: Park, Royce
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 15
  givenname: Jessica S.
  surname: Johnson
  fullname: Johnson, Jessica S.
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 16
  givenname: Bibi S.
  surname: Kassim
  fullname: Kassim, Bibi S.
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 17
  givenname: Laura
  surname: Sloofman
  fullname: Sloofman, Laura
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai
– sequence: 18
  givenname: Eugenio
  orcidid: 0000-0002-8889-658X
  surname: Mattei
  fullname: Mattei, Eugenio
  organization: Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
– sequence: 19
  givenname: Zhiping
  orcidid: 0000-0002-3032-7966
  surname: Weng
  fullname: Weng, Zhiping
  organization: Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
– sequence: 20
  givenname: Solveig K.
  orcidid: 0000-0003-1033-0954
  surname: Sieberts
  fullname: Sieberts, Solveig K.
  organization: Systems Biology, Sage Bionetworks
– sequence: 21
  givenname: Mette A.
  surname: Peters
  fullname: Peters, Mette A.
  organization: Systems Biology, Sage Bionetworks
– sequence: 22
  givenname: Brent T.
  surname: Harris
  fullname: Harris, Brent T.
  organization: Department of Neurology, Georgetown University, Human Brain Collection Core, NIMH
– sequence: 23
  givenname: Barbara K.
  surname: Lipska
  fullname: Lipska, Barbara K.
  organization: Human Brain Collection Core, NIMH
– sequence: 24
  givenname: Pamela
  surname: Sklar
  fullname: Sklar, Pamela
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
– sequence: 25
  givenname: Panos
  orcidid: 0000-0002-4640-6239
  surname: Roussos
  fullname: Roussos, Panos
  email: panagiotis.roussos@mssm.edu
  organization: Department of Genetics and Genomic Sciences, Icahn Institute of Multiscale Biology, Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center
– sequence: 26
  givenname: Schahram
  orcidid: 0000-0001-7700-0891
  surname: Akbarian
  fullname: Akbarian, Schahram
  email: schahram.akbarian@mssm.edu
  organization: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30038276$$D View this record in MEDLINE/PubMed
BookMark eNp9kl1v1SAYgBsz4z70B3hjSLzRi04opZTL5cTNJUtM_LgmlL6csrVQgSbqr5eeM13OooYQPvI88PLynhZHzjsoipcEnxNM23exJkzQEpN27bzET4oTwuqmJLxqjvIcC142FWuOi9MYbzHGnLXiWXFMcdYr3pwUcQPjWMYZtDVWo8HGlO9Ak-_XtUrWOzSpOSLrUBoADcukHDLBu6RGNPoO0GjdHYp6sD_9PARwVqFg4x1Kfmc4WDKdYZjtFpyf4Hnx1Kgxwov78az4evn-y-ZDefPx6npzcVNq1lapVFQRRqHl0Fd10_Ce1rjpwPSU9YwK0QI2Qtd9JxjTVHcMFKZGtx0XrGmNpmfFm_25c_DfFohJTjbq_F7lwC9RVjkdrOYYi4y-foTe-iXkqHdUIzDllDxQWzWCtM74FJReD5UXjFecVkTUmTr_C5VbD5PVObvG5v0D4e2BkJkE39NWLTHK68-fDtlX94Eu3QS9nIOdVPghf_9oBsge0MHHGMD8QQiWa9XIfdXIXDFr5xJnhz9ytE27v8-R2_G_ZrU3Y77FbSE85O3f0i9KNdQf
CitedBy_id crossref_primary_10_1038_s41380_021_01079_0
crossref_primary_10_1038_s41419_020_03105_5
crossref_primary_10_1016_j_biopsych_2022_04_018
crossref_primary_10_1016_j_schres_2019_07_025
crossref_primary_10_1038_s41467_020_20605_2
crossref_primary_10_1126_science_aat4311
crossref_primary_10_1038_s41593_022_01032_6
crossref_primary_10_3390_genes10060432
crossref_primary_10_1038_s41467_022_33885_7
crossref_primary_10_1093_brain_awz295
crossref_primary_10_1002_eji_201970107
crossref_primary_10_1016_j_nbd_2023_106284
crossref_primary_10_1186_s13059_019_1747_7
crossref_primary_10_1016_j_celrep_2020_107716
crossref_primary_10_1016_j_biopsych_2020_03_008
crossref_primary_10_3389_fpsyt_2020_540676
crossref_primary_10_3390_genes13111999
crossref_primary_10_1038_s41467_021_24243_0
crossref_primary_10_3390_cells13161393
crossref_primary_10_1038_s41380_022_01857_4
crossref_primary_10_1124_pr_119_017681
crossref_primary_10_1134_S1022795423080082
crossref_primary_10_1007_s12031_022_02079_7
crossref_primary_10_1038_s41593_024_01658_8
crossref_primary_10_1126_sciadv_abm1077
crossref_primary_10_2139_ssrn_3353219
crossref_primary_10_1038_s41380_021_01092_3
crossref_primary_10_1159_000512716
crossref_primary_10_1093_bioinformatics_btaa687
crossref_primary_10_1016_j_biopsych_2020_06_033
crossref_primary_10_1038_s41380_020_0775_8
crossref_primary_10_1016_j_crmeth_2024_100911
crossref_primary_10_1016_j_celrep_2021_108754
crossref_primary_10_5582_bst_2022_01358
crossref_primary_10_7554_eLife_92393_3
crossref_primary_10_1016_j_neubiorev_2020_03_005
crossref_primary_10_4103_1673_5374_385308
crossref_primary_10_1186_s13073_023_01195_2
crossref_primary_10_1016_j_schres_2019_06_017
crossref_primary_10_1093_cercor_bhac301
crossref_primary_10_31887_DCNS_2019_21_4_sakbarian
crossref_primary_10_1016_j_biopsych_2020_09_016
crossref_primary_10_1093_molbev_msae001
crossref_primary_10_1126_science_adh4265
crossref_primary_10_1038_s41380_022_01768_4
crossref_primary_10_1038_s41392_022_01078_9
crossref_primary_10_1080_15592294_2021_1896983
crossref_primary_10_1093_brain_awad071
crossref_primary_10_1016_j_schres_2021_05_011
crossref_primary_10_1016_j_gde_2020_05_007
crossref_primary_10_3390_life11010062
crossref_primary_10_1038_s41467_019_14269_w
crossref_primary_10_3389_fncel_2022_1046692
crossref_primary_10_1016_j_conb_2019_05_009
crossref_primary_10_4196_kjpp_2018_22_6_679
crossref_primary_10_5498_wjp_v11_i10_711
crossref_primary_10_31857_S0016675823080088
crossref_primary_10_3389_fnmol_2022_948456
crossref_primary_10_1002_eji_202170126
crossref_primary_10_1073_pnas_1918241117
crossref_primary_10_1038_s41380_021_01201_2
crossref_primary_10_1186_s13024_021_00450_7
crossref_primary_10_1038_s41467_021_21917_7
crossref_primary_10_3390_cells9020366
crossref_primary_10_1093_nar_gkz808
crossref_primary_10_1038_s41386_022_01524_w
crossref_primary_10_2174_1574893616666211214110625
crossref_primary_10_7554_eLife_64833
crossref_primary_10_1093_bioinformatics_btaa067
crossref_primary_10_1038_s41588_022_01170_4
crossref_primary_10_7554_eLife_92393
crossref_primary_10_1093_nsr_nwae213
crossref_primary_10_1007_s11357_024_01450_3
crossref_primary_10_3390_genes14020243
crossref_primary_10_1038_s41398_021_01762_4
crossref_primary_10_26508_lsa_202101156
crossref_primary_10_1016_j_neuron_2022_06_004
crossref_primary_10_1021_acssensors_1c01287
crossref_primary_10_2174_1871527320666210825101915
crossref_primary_10_1016_j_schres_2022_04_003
Cites_doi 10.1016/j.biocel.2015.05.009
10.1016/j.cell.2015.08.001
10.1214/11-AOAS466
10.1038/nn.4399
10.1093/hmg/dds164
10.1038/nbt.1508
10.1186/s12859-016-1323-z
10.1126/scisignal.aaa0069
10.1038/nn.4632
10.1038/ng.2802
10.1038/nature14248
10.1093/bioinformatics/btp324
10.1101/gr.107524.110
10.1038/nature13835
10.1038/nature14252
10.1038/nbt.1630
10.1371/journal.pgen.1006125
10.1002/ajmg.a.36174
10.1038/nrg2905
10.1371/journal.pgen.1003433
10.3758/CABN.7.4.391
10.1126/science.1262110
10.1038/nbt.1518
10.1016/j.cell.2016.10.031
10.1038/nn.3706
10.2217/pgs.14.96
10.1093/bioinformatics/btt656
10.1038/nm.2828
10.1038/ng.3359
10.1186/1471-2202-9-42
10.1038/ng.3552
10.1038/nature13595
10.1038/ng.3404
10.1084/jem.20151271
10.1016/j.biopsych.2016.03.1048
10.1186/gb-2008-9-9-r137
10.1038/nn.3922
10.1016/j.cell.2015.07.048
10.1038/nature14177
10.1038/nature11247
10.1126/science.aaa8954
10.1038/nn.4587
10.1073/pnas.1001702107
10.1038/nn.4156
10.1038/ng.3097
10.1093/bioinformatics/btt351
10.1038/ng.3467
10.1073/pnas.1210055109
10.1038/nature10523
10.1038/nbt1010-1045
10.1093/bioinformatics/btp616
10.1038/ng.3396
10.1126/science.1249547
10.1038/nn.4409
10.1073/pnas.0605843103
10.1186/1471-2164-15-284
10.1126/science.aaf1204
10.1038/nature17671
10.1038/sj.npp.1301554
10.1093/bioinformatics/btv145
10.1093/bioinformatics/btr509
10.1126/science.aad7038
10.1093/bioinformatics/btq033
10.1126/science.aad6469
10.1186/gb-2010-11-3-r25
10.1523/ENEURO.0212-17.2017
10.1093/bioinformatics/btv562
10.1111/j.2517-6161.1995.tb02031.x
10.1101/294918
ContentType Journal Article
Copyright The Author(s) 2018
COPYRIGHT 2018 Nature Publishing Group
Copyright Nature Publishing Group Aug 2018
Copyright_xml – notice: The Author(s) 2018
– notice: COPYRIGHT 2018 Nature Publishing Group
– notice: Copyright Nature Publishing Group Aug 2018
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISR
3V.
7QG
7QP
7QR
7TK
7TM
7U7
7U9
7X7
7XB
88E
88G
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M2M
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PSYQQ
Q9U
RC3
7X8
DOI 10.1038/s41593-018-0187-0
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection (subscription)
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Psychology Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest One Psychology
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest Central Basic
Toxicology Abstracts
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE



ProQuest One Psychology
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1546-1726
EndPage 1136
ExternalDocumentID A572732194
30038276
10_1038_s41593_018_0187_0
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIMH NIH HHS
  grantid: P50 MH106934
– fundername: Wellcome Trust
– fundername: NIMH NIH HHS
  grantid: U01 MH103339
– fundername: NIMH NIH HHS
  grantid: U01 MH103365
– fundername: NIA NIH HHS
  grantid: P01 AG002219
– fundername: NIMH NIH HHS
  grantid: U01 MH103392
– fundername: NIA NIH HHS
  grantid: R01 AG033193
– fundername: NIMH NIH HHS
  grantid: R01 MH105898
– fundername: NIMH NIH HHS
  grantid: R21 MH105881
– fundername: NIMH NIH HHS
  grantid: U01 MH103346
GroupedDBID ---
-DZ
.55
.GJ
0R~
123
29M
2FS
36B
39C
3V.
4.4
53G
5BI
5RE
70F
7X7
85S
88E
8AO
8FI
8FJ
8R4
8R5
AAEEF
AARCD
AAYZH
AAZLF
ABAWZ
ABDBF
ABIVO
ABJNI
ABLJU
ABUWG
ACBWK
ACGFS
ACIWK
ACNCT
ACPRK
ACUHS
ADBBV
AENEX
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
D0L
DB5
DU5
DWQXO
EAD
EAP
EBC
EBD
EBS
EE.
EJD
EMB
EMK
EMOBN
EPL
EPS
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IGS
IHR
INH
INR
IPY
ISR
ITC
M1P
M2M
M7P
MVM
N9A
NNMJJ
O9-
ODYON
P2P
PQQKQ
PROAC
PSQYO
PSYQQ
Q2X
RNS
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TSG
TUS
UKHRP
X7M
XJT
YNT
YQT
ZGI
~8M
AAYXX
AETEA
AFANA
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
ABFSG
ACSTC
ADXHL
AEZWR
AFHIU
AHWEU
AIXLP
CGR
CUY
CVF
ECM
EIF
NFIDA
NPM
PJZUB
PPXIY
PQGLB
PMFND
7QG
7QP
7QR
7TK
7TM
7U7
7U9
7XB
8FD
8FE
8FH
8FK
C1K
FR3
H94
K9.
LK8
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
ID FETCH-LOGICAL-c582t-a3a153e87ed24667d3406befd35d53998e0f9c4db955c3cb5ea03fc8b79568fc3
IEDL.DBID 7X7
ISSN 1097-6256
1546-1726
IngestDate Fri Jul 11 05:30:32 EDT 2025
Sat Aug 23 13:20:06 EDT 2025
Tue Jun 17 21:38:21 EDT 2025
Tue Jun 10 20:41:43 EDT 2025
Fri Jun 27 05:08:33 EDT 2025
Mon Jul 21 06:03:23 EDT 2025
Tue Jul 01 03:21:46 EDT 2025
Thu Apr 24 22:58:49 EDT 2025
Fri Feb 21 02:39:26 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c582t-a3a153e87ed24667d3406befd35d53998e0f9c4db955c3cb5ea03fc8b79568fc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-4640-6239
0000-0002-3032-7966
0000-0003-4873-2764
0000-0003-1033-0954
0000-0001-7700-0891
0000-0002-8889-658X
0000-0002-0957-0224
OpenAccessLink https://pure.au.dk/portal/en/publications/257a3a8f-6b05-4cb4-b5dd-5fc86ab0db35
PMID 30038276
PQID 2076903731
PQPubID 44706
PageCount 11
ParticipantIDs proquest_miscellaneous_2075547009
proquest_journals_2076903731
gale_infotracmisc_A572732194
gale_infotracacademiconefile_A572732194
gale_incontextgauss_ISR_A572732194
pubmed_primary_30038276
crossref_primary_10_1038_s41593_018_0187_0
crossref_citationtrail_10_1038_s41593_018_0187_0
springer_journals_10_1038_s41593_018_0187_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-08-01
PublicationDateYYYYMMDD 2018-08-01
PublicationDate_xml – month: 08
  year: 2018
  text: 2018-08-01
  day: 01
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Nature neuroscience
PublicationTitleAbbrev Nat Neurosci
PublicationTitleAlternate Nat Neurosci
PublicationYear 2018
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Mancarci (CR15) 2017; 4
Sun (CR10) 2016; 167
Finucane (CR20) 2015; 47
Moghaddam, Homayoun (CR31) 2008; 33
Huang (CR21) 2017; 20
Lake (CR37) 2016; 352
Kharchenko, Tolstorukov, Park (CR53) 2008; 26
Kundaje (CR5) 2015; 518
CR38
Benjamini, Hochberg (CR59) 1995; 57
Akbarian (CR6) 2015; 18
(CR48) 2012; 489
Kang (CR42) 2011; 478
McKenna (CR49) 2010; 20
Grubert (CR25) 2015; 162
Waszak (CR26) 2015; 162
Le Fevre (CR32) 2013; 161A
Habib (CR17) 2016; 353
CR72
Locke (CR68) 2015; 518
Quinlan, Hall (CR60) 2010; 26
Sullivan (CR39) 2015; 212
Fromer (CR7) 2016; 19
Li (CR50) 2011; 27
Nikpay (CR70) 2015; 47
(CR27) 2015; 348
Gjoneska (CR22) 2015; 518
Zhou, Goren, Bernstein (CR8) 2011; 12
McLean (CR19) 2010; 28
Yu, Wang, He (CR62) 2015; 31
CR47
Posner, Rothbart, Sheese, Tang (CR30) 2007; 7
Penney, Tsai (CR40) 2014; 7
(CR29) 2014; 511
Gel (CR63) 2016; 32
Wood (CR69) 2014; 46
Kawaguchi, Glatt (CR35) 2014; 15
Zhang (CR52) 2008; 9
Robinson, Oshlack (CR57) 2010; 11
Sherwood (CR18) 2006; 103
Gandal (CR36) 2018; 359
Shen, Shao, Liu, Nestler (CR55) 2014; 15
Raj (CR23) 2014; 344
Gaujoux, Seoighe (CR61) 2013; 29
Okbay (CR66) 2016; 48
Kumasaka, Knights, Gaffney (CR28) 2016; 48
Jakovcevski, Akbarian (CR41) 2012; 18
Gandal, Leppa, Won, Parikshak, Geschwind (CR2) 2016; 19
Li, Brown, Huang, Bickel (CR51) 2011; 5
Robinson, McCarthy, Smyth (CR58) 2010; 26
Okbay (CR65) 2016; 533
Sadakata (CR33) 2012; 109
Cheung (CR12) 2010; 107
Rozowsky (CR54) 2009; 27
Jiang, Matevossian, Huang, Straubhaar, Akbarian (CR45) 2008; 9
Li, Durbin (CR46) 2009; 25
Charney, Sklar, Buxbaum, Nestler (CR14) 2018
Bernstein (CR3) 2010; 28
Liu (CR71) 2015; 47
Farh (CR4) 2015; 518
Jones (CR67) 2016; 12
Griswold (CR34) 2012; 21
Kundakovic (CR44) 2017; 81
Liao, Smyth, Shi (CR56) 2014; 30
Yang (CR43) 2015; 67
(CR9) 2015; 18
Hoffman, Schadt (CR24) 2016; 17
Shulha, Cheung, Guo, Akbarian, Weng (CR13) 2013; 9
Lambert (CR64) 2013; 45
Geschwind, Flint (CR1) 2015; 349
Huttner (CR16) 2014; 17
Ng (CR11) 2017; 20
MI Posner (187_CR30) 2007; 7
KL Huang (187_CR21) 2017; 20
T Raj (187_CR23) 2014; 344
MD Robinson (187_CR57) 2010; 11
AR Quinlan (187_CR60) 2010; 26
E Gjoneska (187_CR22) 2015; 518
187_CR47
MD Robinson (187_CR58) 2010; 26
HP Shulha (187_CR13) 2013; 9
L Shen (187_CR55) 2014; 15
M Fromer (187_CR7) 2016; 19
G Yu (187_CR62) 2015; 31
AJ Griswold (187_CR34) 2012; 21
Y Zhang (187_CR52) 2008; 9
DH Geschwind (187_CR1) 2015; 349
JZ Liu (187_CR71) 2015; 47
DS Charney (187_CR14) 2018
CY McLean (187_CR19) 2010; 28
PV Kharchenko (187_CR53) 2008; 26
J Rozowsky (187_CR54) 2009; 27
B Moghaddam (187_CR31) 2008; 33
M Nikpay (187_CR70) 2015; 47
JC Lambert (187_CR64) 2013; 45
AR Wood (187_CR69) 2014; 46
N Habib (187_CR17) 2016; 353
Schizophrenia Working Group of the Psychiatric Genomics Consortium. (187_CR29) 2014; 511
HB Huttner (187_CR16) 2014; 17
CC Sherwood (187_CR18) 2006; 103
187_CR38
AK Fevre Le (187_CR32) 2013; 161A
J Penney (187_CR40) 2014; 7
Q Li (187_CR51) 2011; 5
F Grubert (187_CR25) 2015; 162
S Akbarian (187_CR6) 2015; 18
ENCODE Project Consortium. (187_CR48) 2012; 489
AE Locke (187_CR68) 2015; 518
I Cheung (187_CR12) 2010; 107
GTEx Consortium. (187_CR27) 2015; 348
Y Benjamini (187_CR59) 1995; 57
BO Mancarci (187_CR15) 2017; 4
HJ Kang (187_CR42) 2011; 478
J Yang (187_CR43) 2015; 67
A Okbay (187_CR66) 2016; 48
SE Jones (187_CR67) 2016; 12
MJ Gandal (187_CR2) 2016; 19
T Sadakata (187_CR33) 2012; 109
M Kundakovic (187_CR44) 2017; 81
KKH Farh (187_CR4) 2015; 518
M Jakovcevski (187_CR41) 2012; 18
B Gel (187_CR63) 2016; 32
BE Bernstein (187_CR3) 2010; 28
SM Waszak (187_CR26) 2015; 162
187_CR72
Y Jiang (187_CR45) 2008; 9
A McKenna (187_CR49) 2010; 20
JM Sullivan (187_CR39) 2015; 212
VW Zhou (187_CR8) 2011; 12
HK Finucane (187_CR20) 2015; 47
H Li (187_CR50) 2011; 27
Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium. (187_CR9) 2015; 18
A Kundaje (187_CR5) 2015; 518
GE Hoffman (187_CR24) 2016; 17
N Kumasaka (187_CR28) 2016; 48
B Ng (187_CR11) 2017; 20
BB Lake (187_CR37) 2016; 352
W Sun (187_CR10) 2016; 167
MJ Gandal (187_CR36) 2018; 359
R Gaujoux (187_CR61) 2013; 29
DM Kawaguchi (187_CR35) 2014; 15
Y Liao (187_CR56) 2014; 30
H Li (187_CR46) 2009; 25
A Okbay (187_CR65) 2016; 533
References_xml – volume: 67
  start-page: 58
  year: 2015
  end-page: 64
  ident: CR43
  article-title: Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2015.05.009
– volume: 162
  start-page: 1039
  year: 2015
  end-page: 1050
  ident: CR26
  article-title: Population variation and genetic control of modular chromatin architecture in humans
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.001
– volume: 5
  start-page: 1752
  year: 2011
  end-page: 1779
  ident: CR51
  article-title: Measuring reproducibility of high-throughput experiments
  publication-title: Ann. Appl. Stat
  doi: 10.1214/11-AOAS466
– volume: 19
  start-page: 1442
  year: 2016
  end-page: 1453
  ident: CR7
  article-title: Gene expression elucidates functional impact of polygenic risk for schizophrenia
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4399
– volume: 21
  start-page: 3513
  year: 2012
  end-page: 3523
  ident: CR34
  article-title: Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/dds164
– volume: 26
  start-page: 1351
  year: 2008
  end-page: 1359
  ident: CR53
  article-title: Design and analysis of ChIP-seq experiments for DNA-binding proteins
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1508
– volume: 17
  year: 2016
  ident: CR24
  article-title: variancePartition: interpreting drivers of variation in complex gene expression studies
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-016-1323-z
– volume: 7
  start-page: re12
  year: 2014
  ident: CR40
  article-title: Histone deacetylases in memory and cognition
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaa0069
– volume: 20
  start-page: 1418
  year: 2017
  end-page: 1426
  ident: CR11
  article-title: An xQTL map integrates the genetic architecture of the human brain’s transcriptome and epigenome
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4632
– volume: 45
  start-page: 1452
  year: 2013
  end-page: 1458
  ident: CR64
  article-title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2802
– volume: 518
  start-page: 317
  year: 2015
  end-page: 330
  ident: CR5
  article-title: Integrative analysis of 111 reference human epigenomes
  publication-title: Nature
  doi: 10.1038/nature14248
– volume: 25
  start-page: 1754
  year: 2009
  end-page: 1760
  ident: CR46
  article-title: Fast and accurate short read alignment with Burrows-Wheeler transform
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 20
  start-page: 1297
  year: 2010
  end-page: 1303
  ident: CR49
  article-title: The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
  publication-title: Genome Res.
  doi: 10.1101/gr.107524.110
– volume: 518
  start-page: 337
  year: 2015
  end-page: 343
  ident: CR4
  article-title: Genetic and epigenetic fine mapping of causal autoimmune disease variants
  publication-title: Nature
  doi: 10.1038/nature13835
– volume: 518
  start-page: 365
  year: 2015
  end-page: 369
  ident: CR22
  article-title: Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
  publication-title: Nature
  doi: 10.1038/nature14252
– volume: 28
  start-page: 495
  year: 2010
  end-page: 501
  ident: CR19
  article-title: GREAT improves functional interpretation of cis-regulatory regions
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 12
  start-page: e1006125
  year: 2016
  ident: CR67
  article-title: Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1006125
– year: 2018
  ident: CR14
  publication-title: Charney & Nestler’s Neurobiology of Mental Illness
– volume: 161A
  start-page: 3166
  year: 2013
  end-page: 3175
  ident: CR32
  article-title: FOXP1 mutations cause intellectual disability and a recognizable phenotype
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.36174
– volume: 12
  start-page: 7
  year: 2011
  end-page: 18
  ident: CR8
  article-title: Charting histone modifications and the functional organization of mammalian genomes
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2905
– volume: 9
  start-page: e1003433
  year: 2013
  ident: CR13
  article-title: Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003433
– volume: 7
  start-page: 391
  year: 2007
  end-page: 395
  ident: CR30
  article-title: The anterior cingulate gyrus and the mechanism of self-regulation
  publication-title: Cogn. Affect. Behav. Neurosci.
  doi: 10.3758/CABN.7.4.391
– volume: 348
  start-page: 648
  year: 2015
  end-page: 660
  ident: CR27
  article-title: The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
  publication-title: Science
  doi: 10.1126/science.1262110
– volume: 27
  start-page: 66
  year: 2009
  end-page: 75
  ident: CR54
  article-title: PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1518
– volume: 167
  start-page: 1385
  year: 2016
  end-page: 1397.e1311
  ident: CR10
  article-title: Histone acetylome-wide association study of autism spectrum disorder
  publication-title: Cell
  doi: 10.1016/j.cell.2016.10.031
– volume: 17
  start-page: 801
  year: 2014
  end-page: 803
  ident: CR16
  article-title: The age and genomic integrity of neurons after cortical stroke in humans
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3706
– volume: 15
  start-page: 1451
  year: 2014
  end-page: 1459
  ident: CR35
  article-title: GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis
  publication-title: Pharmacogenomics
  doi: 10.2217/pgs.14.96
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: CR56
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 18
  start-page: 1194
  year: 2012
  end-page: 1204
  ident: CR41
  article-title: Epigenetic mechanisms in neurological disease
  publication-title: Nat. Med.
  doi: 10.1038/nm.2828
– volume: 47
  start-page: 979
  year: 2015
  end-page: 986
  ident: CR71
  article-title: Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3359
– volume: 9
  year: 2008
  ident: CR45
  article-title: Isolation of neuronal chromatin from brain tissue
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-9-42
– volume: 48
  start-page: 624
  year: 2016
  end-page: 633
  ident: CR66
  article-title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3552
– volume: 511
  start-page: 421
  year: 2014
  end-page: 427
  ident: CR29
  article-title: Biological insights from 108 schizophrenia-associated genetic loci
  publication-title: Nature
  doi: 10.1038/nature13595
– volume: 47
  start-page: 1228
  year: 2015
  end-page: 1235
  ident: CR20
  article-title: Partitioning heritability by functional annotation using genome-wide association summary statistics
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3404
– volume: 212
  start-page: 1771
  year: 2015
  end-page: 1781
  ident: CR39
  article-title: Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151271
– ident: CR47
– ident: CR72
– volume: 81
  start-page: 162
  year: 2017
  end-page: 170
  ident: CR44
  article-title: Practical guidelines for high-resolution epigenomic profiling of nucleosomal histones in postmortem human brain tissue
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2016.03.1048
– volume: 9
  year: 2008
  ident: CR52
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 18
  start-page: 199
  year: 2015
  end-page: 209
  ident: CR9
  article-title: Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3922
– volume: 162
  start-page: 1051
  year: 2015
  end-page: 1065
  ident: CR25
  article-title: Genetic control of chromatin states in humans involves local and distal chromosomal interactions
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.048
– volume: 518
  start-page: 197
  year: 2015
  end-page: 206
  ident: CR68
  article-title: Genetic studies of body mass index yield new insights for obesity biology
  publication-title: Nature
  doi: 10.1038/nature14177
– volume: 489
  start-page: 57
  year: 2012
  end-page: 74
  ident: CR48
  article-title: An integrated encyclopedia of DNA elements in the human genome
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 349
  start-page: 1489
  year: 2015
  end-page: 1494
  ident: CR1
  article-title: Genetics and genomics of psychiatric disease
  publication-title: Science
  doi: 10.1126/science.aaa8954
– volume: 20
  start-page: 1052
  year: 2017
  end-page: 1061
  ident: CR21
  article-title: A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4587
– volume: 107
  start-page: 8824
  year: 2010
  end-page: 8829
  ident: CR12
  article-title: Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1001702107
– volume: 18
  start-page: 1707
  year: 2015
  end-page: 1712
  ident: CR6
  article-title: The PsychENCODE project
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4156
– volume: 46
  start-page: 1173
  year: 2014
  end-page: 1186
  ident: CR69
  article-title: Defining the role of common variation in the genomic and biological architecture of adult human height
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3097
– volume: 29
  start-page: 2211
  year: 2013
  end-page: 2212
  ident: CR61
  article-title: CellMix: a comprehensive toolbox for gene expression deconvolution
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt351
– volume: 57
  start-page: 289
  year: 1995
  end-page: 300
  ident: CR59
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. R. Stat. Soc. Series B Stat. Methodol.
– volume: 48
  start-page: 206
  year: 2016
  end-page: 213
  ident: CR28
  article-title: Fine-mapping cellular QTLs with RASQUAL and ATAC-seq
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3467
– volume: 109
  start-page: 21104
  year: 2012
  end-page: 21109
  ident: CR33
  article-title: Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1210055109
– volume: 478
  start-page: 483
  year: 2011
  end-page: 489
  ident: CR42
  article-title: Spatio-temporal transcriptome of the human brain
  publication-title: Nature
  doi: 10.1038/nature10523
– volume: 28
  start-page: 1045
  year: 2010
  end-page: 1048
  ident: CR3
  article-title: The NIH Roadmap Epigenomics Mapping Consortium.
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1010-1045
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: CR58
  article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– ident: CR38
– volume: 47
  start-page: 1121
  year: 2015
  end-page: 1130
  ident: CR70
  article-title: A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3396
– volume: 344
  start-page: 519
  year: 2014
  end-page: 523
  ident: CR23
  article-title: Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
  publication-title: Science
  doi: 10.1126/science.1249547
– volume: 19
  start-page: 1397
  year: 2016
  end-page: 1407
  ident: CR2
  article-title: The road to precision psychiatry: translating genetics into disease mechanisms
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4409
– volume: 32
  start-page: 289
  year: 2016
  end-page: 291
  ident: CR63
  article-title: regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests
  publication-title: Bioinformatics
– volume: 103
  start-page: 13606
  year: 2006
  end-page: 13611
  ident: CR18
  article-title: Evolution of increased glia-neuron ratios in the human frontal cortex
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605843103
– volume: 15
  year: 2014
  ident: CR55
  article-title: ngs.plot: quick mining and visualization of next-generation sequencing data by integrating genomic databases
  publication-title: BMC Genom.
  doi: 10.1186/1471-2164-15-284
– volume: 352
  start-page: 1586
  year: 2016
  end-page: 1590
  ident: CR37
  article-title: Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
  publication-title: Science
  doi: 10.1126/science.aaf1204
– volume: 533
  start-page: 539
  year: 2016
  end-page: 542
  ident: CR65
  article-title: Genome-wide association study identifies 74 loci associated with educational attainment
  publication-title: Nature
  doi: 10.1038/nature17671
– volume: 33
  start-page: 42
  year: 2008
  end-page: 55
  ident: CR31
  article-title: Divergent plasticity of prefrontal cortex networks.
  publication-title: Neuropsychopharmacology.
  doi: 10.1038/sj.npp.1301554
– volume: 31
  start-page: 2382
  year: 2015
  end-page: 2383
  ident: CR62
  article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 27
  start-page: 2987
  year: 2011
  end-page: 2993
  ident: CR50
  article-title: A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr509
– volume: 353
  start-page: 925
  year: 2016
  end-page: 928
  ident: CR17
  article-title: Div-Seq: single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons
  publication-title: Science
  doi: 10.1126/science.aad7038
– volume: 26
  start-page: 841
  year: 2010
  end-page: 842
  ident: CR60
  article-title: BEDTools: a flexible suite of utilities for comparing genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq033
– volume: 359
  start-page: 693
  year: 2018
  end-page: 697
  ident: CR36
  article-title: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
  publication-title: Science
  doi: 10.1126/science.aad6469
– volume: 11
  year: 2010
  ident: CR57
  article-title: A scaling normalization method for differential expression analysis of RNA-seq data
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
– volume: 4
  start-page: ENEURO.0212-17.2017
  year: 2017
  ident: CR15
  article-title: Cross-laboratory analysis of brain cell type transcriptomes with applications to interpretation of bulk tissue data
  publication-title: eNeuro
  doi: 10.1523/ENEURO.0212-17.2017
– volume: 4
  start-page: ENEURO.0212-17.
  year: 2017
  ident: 187_CR15
  publication-title: eNeuro
  doi: 10.1523/ENEURO.0212-17.2017
– volume: 15
  start-page: 1451
  year: 2014
  ident: 187_CR35
  publication-title: Pharmacogenomics
  doi: 10.2217/pgs.14.96
– volume: 20
  start-page: 1418
  year: 2017
  ident: 187_CR11
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4632
– volume: 344
  start-page: 519
  year: 2014
  ident: 187_CR23
  publication-title: Science
  doi: 10.1126/science.1249547
– volume: 28
  start-page: 1045
  year: 2010
  ident: 187_CR3
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1010-1045
– volume: 518
  start-page: 365
  year: 2015
  ident: 187_CR22
  publication-title: Nature
  doi: 10.1038/nature14252
– volume: 478
  start-page: 483
  year: 2011
  ident: 187_CR42
  publication-title: Nature
  doi: 10.1038/nature10523
– volume: 67
  start-page: 58
  year: 2015
  ident: 187_CR43
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2015.05.009
– volume: 27
  start-page: 66
  year: 2009
  ident: 187_CR54
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1518
– volume: 9
  year: 2008
  ident: 187_CR45
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-9-42
– volume: 5
  start-page: 1752
  year: 2011
  ident: 187_CR51
  publication-title: Ann. Appl. Stat
  doi: 10.1214/11-AOAS466
– volume: 17
  start-page: 801
  year: 2014
  ident: 187_CR16
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3706
– volume: 109
  start-page: 21104
  year: 2012
  ident: 187_CR33
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1210055109
– volume: 81
  start-page: 162
  year: 2017
  ident: 187_CR44
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2016.03.1048
– volume: 162
  start-page: 1051
  year: 2015
  ident: 187_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.048
– volume: 28
  start-page: 495
  year: 2010
  ident: 187_CR19
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 518
  start-page: 197
  year: 2015
  ident: 187_CR68
  publication-title: Nature
  doi: 10.1038/nature14177
– volume: 46
  start-page: 1173
  year: 2014
  ident: 187_CR69
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3097
– volume: 32
  start-page: 289
  year: 2016
  ident: 187_CR63
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv562
– volume: 48
  start-page: 206
  year: 2016
  ident: 187_CR28
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3467
– volume: 45
  start-page: 1452
  year: 2013
  ident: 187_CR64
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2802
– volume: 30
  start-page: 923
  year: 2014
  ident: 187_CR56
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 57
  start-page: 289
  year: 1995
  ident: 187_CR59
  publication-title: J. R. Stat. Soc. Series B Stat. Methodol.
  doi: 10.1111/j.2517-6161.1995.tb02031.x
– ident: 187_CR72
– volume: 348
  start-page: 648
  year: 2015
  ident: 187_CR27
  publication-title: Science
  doi: 10.1126/science.1262110
– volume: 533
  start-page: 539
  year: 2016
  ident: 187_CR65
  publication-title: Nature
  doi: 10.1038/nature17671
– volume: 19
  start-page: 1397
  year: 2016
  ident: 187_CR2
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4409
– volume: 47
  start-page: 1228
  year: 2015
  ident: 187_CR20
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3404
– volume: 12
  start-page: e1006125
  year: 2016
  ident: 187_CR67
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1006125
– volume: 17
  year: 2016
  ident: 187_CR24
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-016-1323-z
– volume: 20
  start-page: 1297
  year: 2010
  ident: 187_CR49
  publication-title: Genome Res.
  doi: 10.1101/gr.107524.110
– volume: 7
  start-page: re12
  year: 2014
  ident: 187_CR40
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaa0069
– volume: 511
  start-page: 421
  year: 2014
  ident: 187_CR29
  publication-title: Nature
  doi: 10.1038/nature13595
– volume: 359
  start-page: 693
  year: 2018
  ident: 187_CR36
  publication-title: Science
  doi: 10.1126/science.aad6469
– volume: 47
  start-page: 979
  year: 2015
  ident: 187_CR71
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3359
– volume: 349
  start-page: 1489
  year: 2015
  ident: 187_CR1
  publication-title: Science
  doi: 10.1126/science.aaa8954
– volume: 12
  start-page: 7
  year: 2011
  ident: 187_CR8
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2905
– volume: 21
  start-page: 3513
  year: 2012
  ident: 187_CR34
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/dds164
– volume: 33
  start-page: 42
  year: 2008
  ident: 187_CR31
  publication-title: Neuropsychopharmacology.
  doi: 10.1038/sj.npp.1301554
– volume: 25
  start-page: 1754
  year: 2009
  ident: 187_CR46
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 27
  start-page: 2987
  year: 2011
  ident: 187_CR50
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr509
– volume: 31
  start-page: 2382
  year: 2015
  ident: 187_CR62
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 20
  start-page: 1052
  year: 2017
  ident: 187_CR21
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4587
– volume: 26
  start-page: 841
  year: 2010
  ident: 187_CR60
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq033
– volume-title: Charney & Nestler’s Neurobiology of Mental Illness
  year: 2018
  ident: 187_CR14
– volume: 353
  start-page: 925
  year: 2016
  ident: 187_CR17
  publication-title: Science
  doi: 10.1126/science.aad7038
– ident: 187_CR38
  doi: 10.1101/294918
– volume: 11
  year: 2010
  ident: 187_CR57
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
– volume: 7
  start-page: 391
  year: 2007
  ident: 187_CR30
  publication-title: Cogn. Affect. Behav. Neurosci.
  doi: 10.3758/CABN.7.4.391
– volume: 107
  start-page: 8824
  year: 2010
  ident: 187_CR12
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1001702107
– volume: 19
  start-page: 1442
  year: 2016
  ident: 187_CR7
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4399
– volume: 489
  start-page: 57
  year: 2012
  ident: 187_CR48
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 26
  start-page: 139
  year: 2010
  ident: 187_CR58
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 29
  start-page: 2211
  year: 2013
  ident: 187_CR61
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt351
– volume: 26
  start-page: 1351
  year: 2008
  ident: 187_CR53
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1508
– volume: 103
  start-page: 13606
  year: 2006
  ident: 187_CR18
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605843103
– volume: 352
  start-page: 1586
  year: 2016
  ident: 187_CR37
  publication-title: Science
  doi: 10.1126/science.aaf1204
– ident: 187_CR47
– volume: 9
  year: 2008
  ident: 187_CR52
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 162
  start-page: 1039
  year: 2015
  ident: 187_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.001
– volume: 518
  start-page: 317
  year: 2015
  ident: 187_CR5
  publication-title: Nature
  doi: 10.1038/nature14248
– volume: 161A
  start-page: 3166
  year: 2013
  ident: 187_CR32
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.36174
– volume: 212
  start-page: 1771
  year: 2015
  ident: 187_CR39
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151271
– volume: 18
  start-page: 1194
  year: 2012
  ident: 187_CR41
  publication-title: Nat. Med.
  doi: 10.1038/nm.2828
– volume: 47
  start-page: 1121
  year: 2015
  ident: 187_CR70
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3396
– volume: 518
  start-page: 337
  year: 2015
  ident: 187_CR4
  publication-title: Nature
  doi: 10.1038/nature13835
– volume: 9
  start-page: e1003433
  year: 2013
  ident: 187_CR13
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003433
– volume: 15
  year: 2014
  ident: 187_CR55
  publication-title: BMC Genom.
  doi: 10.1186/1471-2164-15-284
– volume: 167
  start-page: 1385
  year: 2016
  ident: 187_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2016.10.031
– volume: 18
  start-page: 199
  year: 2015
  ident: 187_CR9
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3922
– volume: 18
  start-page: 1707
  year: 2015
  ident: 187_CR6
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4156
– volume: 48
  start-page: 624
  year: 2016
  ident: 187_CR66
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3552
SSID ssj0007589
Score 2.555963
Snippet Risk variants for schizophrenia affect more than 100 genomic loci, yet cell- and tissue-specific roles underlying disease liability remain poorly...
SourceID proquest
gale
pubmed
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1126
SubjectTerms 45
45/15
45/23
631/114/1314
692/699/476/1799
Alzheimer Disease - genetics
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain Mapping
Brain research
Chromatin
Chromatin - genetics
Corporate sponsorship
Cortex (cingulate)
Depletion
Depression - genetics
Depression - pathology
Educational Status
Enhancers
Epigenesis, Genetic - genetics
Epigenetic inheritance
Frontal lobe
Frontal Lobe - metabolism
Frontal Lobe - pathology
Frontal lobes
Gene mapping
Genetic aspects
Genetic Predisposition to Disease - genetics
Genetic Variation
Genome-Wide Association Study
Gyrus Cinguli - pathology
Health aspects
Histones
Histones - genetics
Humans
Landscape
Legal liability
Liability
Medical schools
Mental disorders
Methylation
Molecular neurobiology
Neurobiology
Neurogenetics
Neurons
Neurosciences
Neurosis
Neurotic Disorders - genetics
Neurotic Disorders - pathology
Physiological aspects
Post-translational modifications
Prefrontal cortex
Prefrontal Cortex - pathology
Psychosis
Quantitative genetics
Quantitative trait loci
Resource
Risk
Risk factors
Schizophrenia
Schizophrenia - genetics
Schizophrenia - metabolism
Title Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome
URI https://link.springer.com/article/10.1038/s41593-018-0187-0
https://www.ncbi.nlm.nih.gov/pubmed/30038276
https://www.proquest.com/docview/2076903731
https://www.proquest.com/docview/2075547009
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFH-C7cIFAeMjMCaDEEigiNRO4uSEyrRpcJjQYFJvlj8RUpsU0h7473nPdbp1Ejv0UOW5sfs-7ffzewBvBHeB197mRk5cXlayRZWqea5NU3DfaMl1RFuc12eX5ddZNUsHbkOCVY42MRpq11s6I6eTENzICSkmn5a_c-oaRdnV1ELjLuxT6TKSajnbbrjQG8YWeJRkzTHOr8espmg-Dui4CLk2ISgX6lmx45duWudr7ulGvjS6odMHcD_Fj2y6YfhDuOO7R3Aw7XDvvPjL3rKI6IxH5QcwHPv5PKe7lIQHYrG0cOfZonf0PbKELfRyYL86hnEgi_36WKCSBvgKgmEwyu-y4TowjxEYna36OCJWw6T5-GWs9rrwj-Hy9OTH8Vmemizktmr4KtdCo9HzjfSOl3UtnUAXb3xwonJUtbbxRWht6UxbVVZYU3ldiGAbI-miYbDiCex1OPlnwFwIpg0BgzLpSymsNiZMQmswIgml5jKDYvyLlU0VyKkRxlzFTLho1IYrCjlCH6mKDN5vhyw35TduI35NfFNU1qIj3MxPvR4G9eX7hZpWFKehdS4zeJeIQo8vtzpdQ8AlUCWsHcrDHUrUO7v7eBQPlfR-UFdSmsGr7WMaSVi2zvfrSIMxnMTgNoOnG7Hark1QppbLOoMPo5xd_fh_F_789qm8gHs8CjrJ-iHsrf6s_UsMpVbmKOrLEex_Pjn_dvEPSG4a0w
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-N8QAvCBgfgQEG8SGBIlI7idMHhKrB1LKxB9ikvnm2Y0-T2qSQVmj_FH8jd27SrZPY2x7yEOWc2PGd78738x3Aa8FLz3NnYyN7ZZxmso8ilfNYmyLhrtCS64C2OMiHR-m3cTbegL_dWRiCVXZrYlioy9rSHjnthKAjJ6TofZ79iqlqFEVXuxIaS7bYc2d_0GVrPo2-4Py-4Xz36-HOMG6rCsQ2K_g81kKjlLtCupKneS5LgTrNOF-KrKQ0rYVLfN-mpelnmRXWZE4nwtvCSDpZ563A996Am6h4E3L25Hjl4KH2DSX3KKgbo1-Rd1FUUXxsUFESUq5H0DGU62RND17WBhfU4aX4bFB7u3fhTmuvssGSwe7Bhqvuw9agQl99esbesoAgDVvzW9DsuMkkprObhD9iIZVx5di0Luk-sACb6lnDTiuGdicL9QGZpxQK-AmCfTCKJ7PmIhCQEfidzevQImTfpP64WcguO3UP4Ohafv9D2Kyw84-Bld6bvvdoBEqXSmG1Mb7n-wYtIJ9qLiNIul-sbJvxnApvTFSIvItCLWdF4YzQJVUSwftVk9ky3cdVxK9o3hSl0agIp3OiF02jRj9_qEFGdiFqgzSCdy2Rr_HjVrfHHnAIlHlrjXJ7jRLl3K4_7thDtetMo86lIoKXq8fUkrBzlasXgQZtRonGdASPlmy1GpugyDCXeQQfOj47f_l_B_7k6q68gFvDw-_7an90sPcUbvPA9MT327A5_71wz9CMm5vnQXYYHF-3sP4DjOFW1A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTkK8IGB8BAYYxIcEipbaSZw8IFS2VStD1TSYtDcTOzZCatNCWqH9a_x13DlJt05ib3vIQ5RzYufufHe-n88ArwQvHU-tCbXsl2GcyBxVKuVhobOI26yQvPBoi3F6cBJ_Pk1ON-BvtxeGYJXdnOgn6nJmaI2cVkIwkBNS9HdcC4s42ht-nP8K6QQpyrR2x2k0InJoz_5g-FZ_GO0hr19zPtz_tnsQticMhCbJ-CIsRIEabzNpSx6nqSwF2jdtXSmSkkq2ZjZyuYlLnSeJEUYntoiEM5mWtMvOGYHvvQGbkqKiHmx-2h8fHa_sAHriuc-15jLEKCPtcqoi26nRbBJurk9AMtTyaM0qXrYNF4zjpWytN4LDO3C79V7ZoBG3u7Bhq3uwNagwcp-esTfM40n9Qv0W1Lt2MglpJyehkZgvbFxZNp2VdO8Fgk2Lec1-Vgy9UOZPC2SOCirgJwgEwii7zOqLsEBGUHi2mPkWvhYn9cfOfa3Zqb0PJ9fCgAfQq7Dzj4CVzuncOXQJpY2lMIXWru9yjf6QiwsuA4i6X6xMW_-cjuGYKJ-HF5lquKKQI3RJFQXwbtVk3hT_uIr4JfFNUVGNisTzR7GsazX6eqwGCXmJaBviAN62RG6GHzdFuwkCh0B1uNYot9coUevN-uNOPFQ769TqXEcCeLF6TC0JSVfZ2dLToAcp0bUO4GEjVquxCcoTc5kG8L6Ts_OX_3fgj6_uynO4iYqqvozGh0_gFvcyT2K_Db3F76V9ij7dQj9rlYfB9-vW13-Rh1xv
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cell-specific+histone+modification+maps+in+the+human+frontal+lobe+link+schizophrenia+risk+to+the+neuronal+epigenome&rft.jtitle=Nature+neuroscience&rft.au=Girdhar%2C+Kiran&rft.au=Hoffman%2C+Gabriel+E&rft.au=Jiang%2C+Yan&rft.au=Brown%2C+Leanne&rft.date=2018-08-01&rft.pub=Nature+Publishing+Group&rft.issn=1097-6256&rft.eissn=1546-1726&rft.volume=21&rft.issue=8&rft.spage=1126&rft.epage=1136&rft_id=info:doi/10.1038%2Fs41593-018-0187-0&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1097-6256&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1097-6256&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1097-6256&client=summon