Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

• Published in: Toxicology and applied pharmacology Vol. 299; pp. 70 - 77
• Main Authors: Ilinskaya, Anna N., Dobrovolskaia, Marina A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2016
• Subjects: 60 APPLIED LIFE SCIENCES; Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - toxicity; ANAPHYLAXIS; Animals; ANTIBODIES; Antibody; ANTIBODY FORMATION; Antigenic Modulation - drug effects; Antigenic Modulation - immunology; Antigenicity; BIOTECHNOLOGY; CARRIERS; Comprehension; Cytokines; Drug Carriers - administration & dosage; Drug Carriers - toxicity; DRUG DELIVERY; Drug Delivery Systems - adverse effects; Drug Delivery Systems - methods; ENGINEERS; Forecasting; Humans; Immunity, Cellular - drug effects; Immunity, Cellular - immunology; Immunogenetic Phenomena - drug effects; Immunogenetic Phenomena - immunology; Immunogenicity; LYMPHOKINES; NANOMATERIALS; NANOPARTICLES; Nanostructures - administration & dosage; Nanostructures - toxicity; PARTICULATES; Phagocytosis; Preclinical; REVIEWS; Nanoparticles; Anaphylaxis; Immunogenicity; Cytokines; Antigenicity; Antibody; Preclinical; Phagocytosis

Nanoparticle immunogenicity and antigenicity have been under investigation for many years. During the past decade, significant progress has been made in understanding what makes a nanoparticle immunogenic, how immune cells respond to nanoparticles, what consequences of nanoparticle-specific antibody...