A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice[S]

• Published in: Journal of lipid research Vol. 52; no. 2; pp. 289 - 298
• Main Authors: Henkel, Anne S., Anderson, Kristy A., Dewey, Amanda M., Kavesh, Mark H., Green, Richard M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2011; American Society for Biochemistry and Molecular Biology; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Animals; bile acids; Bile Acids and Salts - metabolism; Cholesterol - metabolism; Cholesterol 7-alpha-Hydroxylase - biosynthesis; Cholesterol, Dietary - administration & dosage; Extracellular Signal-Regulated MAP Kinases - metabolism; Fibroblast Growth Factors - biosynthesis; Hep G2 Cells; hepatic inflammation; Humans; Interleukin-1beta - biosynthesis; JNK Mitogen-Activated Protein Kinases - metabolism; Liver - drug effects; Liver - metabolism; Male; Mice; Mitogen-Activated Protein Kinases - metabolism; tumor necrosis factor α; Tumor Necrosis Factor-alpha - metabolism; hepatic inflammation; bile acids; tumor necrosis factor α

Cholesterol 7α-hydroxylase (CYP7A1) encodes for the rate-limiting step in the conversion of cholesterol to bile acids in the liver. In response to acute cholesterol feeding, mice upregulate CYP7A1 via stimulation of the liver X receptor (LXR) α. However, the effect of a chronic high-cholesterol diet...