Association between increased serum d-serine and cognitive gains induced by intensive cognitive training in schizophrenia

• Published in: Schizophrenia research Vol. 207; pp. 63 - 69
• Main Authors: Panizzutti, Rogerio, Fisher, Melissa, Garrett, Coleman, Man, Wai Hong, Sena, Walter, Madeira, Caroline, Vinogradov, Sophia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019
• Subjects: Adult; Cognitive Dysfunction - blood; Cognitive Dysfunction - etiology; Cognitive Dysfunction - rehabilitation; Cognitive Remediation; Female; Glycine - blood; Humans; Male; Middle Aged; Neuronal Plasticity - physiology; Neuroplasticity; NMDA receptors; Outcome Assessment, Health Care; Schizophrenia; Schizophrenia - blood; Schizophrenia - complications; Schizophrenia - rehabilitation; Serine - blood; Verbal Learning - physiology; Young Adult; Neuroplasticity; Schizophrenia; NMDA receptors; Cognitive remediation

Neuroscience-guided cognitive training induces significant improvement in cognition in schizophrenia subjects, but the biological mechanisms associated with these changes are unknown. In animals, intensive cognitive activity induces increased brain levels of the NMDA-receptor co-agonist d-serine, a...