Localization and Diagnostic Specificity of Glutamic Acid Decarboxylase Transcript Alterations in the Dorsolateral Prefrontal Cortex in Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 94; no. 4; pp. 322 - 331
• Main Authors: Dowling, Kevin F., Dienel, Samuel J., Barile, Zackery, Bazmi, H. Holly, Lewis, David A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2023
• Subjects: Bipolar disorder; DLPFC; Dorsolateral Prefrontal Cortex; GAD65; GAD67; gamma-Aminobutyric Acid; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Humans; Major depression; Prefrontal Cortex - metabolism; Psychiatric/Mental Health; RNA, Messenger; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenia; Bipolar disorder; DLPFC; GAD67; Major depression; GAD65

Working memory (WM) deficits in schizophrenia are thought to reflect altered inhibition in the dorsolateral prefrontal cortex (DLPFC). This interpretation is supported by findings of lower transcript levels of the 2 enzymes, GAD67 and GAD65, which mediate basal and activity-dependent GABA (gamma-ami...