Complications of Proton Pump Inhibitor Therapy

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 153; no. 1; pp. 35 - 48
• Main Authors: Vaezi, Michael F., Yang, Yu-Xiao, Howden, Colin W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: Causality; Community-Acquired Infections - epidemiology; Community-Acquired Infections - etiology; Complications; Confounding Factors (Epidemiology); Gastroenterology and Hepatology; GERD; Hip Fractures - epidemiology; Hip Fractures - etiology; Humans; Observational Studies as Topic; Pneumonia - epidemiology; Pneumonia - etiology; PPI; Proton Pump Inhibitors - adverse effects; Research Design; RR; RCT; OR; Complications; AIN; CI; NSAID; PPI; CDI; GERD; PA; CAP; BMD; H2RA; HE; odds ratio; H 2RA; proton pump inhibitor; acute interstitial nephritis; bone mineral density; hepatic encephalopathy; Clostridium difficile infection; community-acquired pneumonia; histamine H 2-receptor antagonists; relative risk; randomized controlled trial; pernicious anemia; confidence interval; gastroesophageal reflux disease; nonsteroidal anti-inflammatory drug

Safety issues associated with proton pump inhibitors (PPIs) have recently attracted widespread media and lay attention. Gastroenterologists are frequently asked about the appropriateness of PPI therapy for specific patients. Furthermore, some patients may have had PPI therapy discontinued abruptly o...