Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 155; no. 4; pp. 1218 - 1232.e24
• Main Authors: Pradhan-Sundd, Tirthadipa, Vats, Ravi, Russell, Jacquelyn O., Singh, Sucha, Michael, Adeola Adebayo, Molina, Laura, Kakar, Shelly, Cornuet, Pamela, Poddar, Minakshi, Watkins, Simon C., Nejak-Bowen, Kari N., Monga, Satdarshan P., Sundd, Prithu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018
• Subjects: Animals; Bile - metabolism; Biological Transport; Blood Bile Barrier; Chemical and Drug Induced Liver Injury, Chronic - blood; Chemical and Drug Induced Liver Injury, Chronic - etiology; Chemical and Drug Induced Liver Injury, Chronic - metabolism; Chemical and Drug Induced Liver Injury, Chronic - pathology; Choline Deficiency - complications; Claudins; Claudins - metabolism; Diet-Induced Liver Injury; Disease Models, Animal; Ethionine; Hepatocyte Tight Junction; Hepatocytes - metabolism; Hepatocytes - pathology; Kinetics; Liver - metabolism; Liver - pathology; Membrane Transport Proteins - metabolism; Mice, Inbred C57BL; Permeability; Pyridines; Tight Junctions - metabolism; Tight Junctions - pathology; DDC; CF; EpCAM; ALP; CDE; Hepatocyte Tight Junction; ALT; BBlB; qLIM; IV; TXR; Claudins; TJ; Blood Bile Barrier; CLD; PCR; Diet-Induced Liver Injury; CFDA

Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver i...