Early Oxidative DNA Damages and Late Development of Lung Cancer in Diesel Exhaust-Exposed Rats

• Published in: Environmental research Vol. 84; no. 3; pp. 255 - 264
• Main Authors: Iwai, Kazuro, Adachi, Shuichi, Takahashi, Mihoko, Möller, Lennart, Udagawa, Tadashi, Mizuno, Satoru, Sugawara, Isamu
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2000; Elsevier
• Subjects: 8-hydroxy-deoxyguanosine; Air; Animals; Biological and medical sciences; Cell Transformation, Neoplastic; diesel; diesel exhaust; DNA adduct; DNA Adducts; DNA Damage; Environmental pollutants toxicology; Female; Inhalation Exposure; lung cancer; Lung Neoplasms - chemically induced; Lung Neoplasms - pathology; Medical sciences; Medicin och hälsovetenskap; Oxidative Stress; Rats; Time Factors; Toxicology; Vehicle Emissions - adverse effects; lung cancer; DNA adduct; 8-hydroxy-deoxyguanosine; diesel exhaust; inhalation exposure; Lung disease; Rat; Respiratory disease; Diesel fuel; Toxicity; Rodentia; Tumorigenicity; Malignant tumor; Bronchopulmonary; Inhalation; Carcinogen; Vertebrata; Chronic; Mammalia; Histopathology; Animal; DNA; Bronchus disease; Exhaust gas; Lesion; Molecular adduct

To demonstrate DNA damages in the early stage of diesel exhaust exposure, an inhalation study of 1 through 12 months was conducted. The lung burden of diesel soot increased with increase in exposure duration. Histologically, hyperplastic foci of alveolar epithelia were found at 6-month exposure and...