Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

• Published in: Translational oncology Vol. 14; no. 9; p. 101147
• Main Authors: Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021; Neoplasia Press; Elsevier
• Subjects: ATRX; DNA damage response; Glioma; IDH1 R132H; Original Research; PARP inhibitor; IDH1 R132H; Glioma; DNA damage response; ATRX; PARP inhibitor

•Drug screen shows that ATRX KO leads to PARP inhibitor sensitivity in glioma cells.•PARPi leads to greater levels of replication stress in ATRX KO cells than WT.•IDH1 R132H and ATRX KO have similar levels of PARP inhibitor sensitivity.•ATRi and PARPi have greater synergy in ATRX KO cells. Alpha Tha...