Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Published in: Nature communications Vol. 10; no. 1; p. 357
• Main Authors: Haworth, Simon, Shapland, Chin Yang, Hayward, Caroline, Prins, Bram P., Felix, Janine F., Medina-Gomez, Carolina, Rivadeneira, Fernando, Wang, Carol, Ahluwalia, Tarunveer S., Vrijheid, Martine, Guxens, Mònica, Sunyer, Jordi, Tachmazidou, Ioanna, Walter, Klaudia, Iotchkova, Valentina, Jackson, Andrew, Cleal, Louise, Huffmann, Jennifer, Min, Josine L., Sass, Lærke, Timmers, Paul R. H. J., Davey Smith, George, Fisher, Simon E., Wilson, James F., Cole, Tim J., Fernandez-Orth, Dietmar, Bønnelykke, Klaus, Bisgaard, Hans, Pennell, Craig E., Jaddoe, Vincent W. V., Dedoussis, George, Timpson, Nicholas, Zeggini, Eleftheria, Vitart, Veronique, St Pourcain, Beate
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.01.2019; Nature Publishing Group; Nature Research; Nature Portfolio
• Subjects: 45; 45/43; 631/208/205/2138; 631/378/2571; 631/378/2583; Adolescent; Adult; Adults; Age; Aged; Aged, 80 and over; Alleles; Babies; Cephalometry; Child; Child development; Children; Chromosomes; Female; Frequency spectrum; Frequency variation; Gene Expression Regulation, Developmental; Gene Frequency; Genetic diversity; Genetic factors; Genetic Loci; Genetic Variation; Genoma humà; Genome, Human; Genome-wide association studies; Genomes; Head; Humanities and Social Sciences; Humans; Male; Marcadors bioquímics; Middle Aged; multidisciplinary; p53 Protein; Pediatrics; Regression analysis; RNA, Messenger - genetics; Science; Science (multidisciplinary); Skull; Skull - anatomy & histology; Skull - metabolism; Tumor Suppressor Protein p53 - genetics; White People

Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include bot...