An in Situ Atlas of Mitochondrial DNA in Mammalian Tissues Reveals High Content in Stem and Proliferative Compartments

• Published in: The American journal of pathology Vol. 190; no. 7; pp. 1565 - 1579
• Main Authors: Chen, Jiayu, Zheng, Qizhi, Peiffer, Lauren B., Hicks, Jessica L., Haffner, Michael C., Rosenberg, Avi Z., Levi, Moshe, Wang, Xiaoxin X., Ozbek, Busra, Baena-Del Valle, Javier, Yegnasubramanian, Srinivasan, De Marzo, Angelo M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020; American Society for Investigative Pathology
• Subjects: Aging - physiology; Animals; Atlases as Topic; Cell Proliferation; DNA Copy Number Variations; DNA, Mitochondrial - analysis; Female; Humans; In Situ Hybridization - methods; Male; Mice; Mice, Inbred C57BL; Stem Cells

Mitochondria regulate ATP production, metabolism, and cell death. Alterations in mitochondrial DNA (mtDNA) sequence and copy number are implicated in aging and organ dysfunction in diverse inherited and sporadic diseases. Because most measurements of mtDNA use homogenates of complex tissues, little...