Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer

• Published in: European urology Vol. 76; no. 4; pp. 469 - 478
• Main Authors: Paschalis, Alec, Sheehan, Beshara, Riisnaes, Ruth, Rodrigues, Daniel Nava, Gurel, Bora, Bertan, Claudia, Ferreira, Ana, Lambros, Maryou B.K., Seed, George, Yuan, Wei, Dolling, David, Welti, Jon C., Neeb, Antje, Sumanasuriya, Semini, Rescigno, Pasquale, Bianchini, Diletta, Tunariu, Nina, Carreira, Suzanne, Sharp, Adam, Oyen, Wim, de Bono, Johann S.
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.10.2019; Elsevier Science
• Subjects: Antigens, Surface - analysis; Antigens, Surface - biosynthesis; BRCA2; Castration-resistant prostate cancer; Defective DNA repair; DNA Repair; Glutamate Carboxypeptidase II - analysis; Glutamate Carboxypeptidase II - biosynthesis; Humans; Male; Prostate cancer; Prostate-specific membrane antigen; Prostatic Neoplasms, Castration-Resistant - chemistry; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - metabolism; Retrospective Studies; Theranostics; Treatment resistance; Tumour heterogeneity; Castration-resistant prostate cancer; Treatment resistance; Prostate-specific membrane antigen; Tumour heterogeneity; Defective DNA repair; BRCA2; Prostate cancer; Theranostics

Prostate-specific membrane antigen (PSMA; folate hydrolase) prostate cancer (PC) expression has theranostic utility. To elucidate PC PSMA expression and associate this with defective DNA damage repair (DDR). Membranous PSMA (mPSMA) expression was scored immunohistochemically from metastatic castrati...