Label-Free Calcium Imaging in Ischemic Retinal Tissue by TOF-SIMS
The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used...
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| Published in | Biophysical journal Vol. 94; no. 10; pp. 4095 - 4102 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
15.05.2008
Biophysical Society The Biophysical Society |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca2+ distribution, compared with other fundamental ions, such as Na+, K+, and Mg2+, were detected during the progression of ischemia. Furthermore, the Ca2+ redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2′-deoxyuridine 5′-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca2+ ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca2+ redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca2+ ion movement. |
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| AbstractList | The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca
2+
distribution, compared with other fundamental ions, such as Na
+
, K
+
, and Mg
2+
, were detected during the progression of ischemia. Furthermore, the Ca
2+
redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2′-deoxyuridine 5′-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca
2+
ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca
2+
redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca
2+
ion movement. The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOP-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca^sup 2+^ distribution, compared with other fundamental ions, such as Na+, K+, and Mg^sup 2+^, were detected during the progression of ischemia. Furthermore, the Ca^sup 2+^ redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca^sup 2+^ ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca^sup 2+^ redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca^sup 2+^ ion movement. [PUBLICATION ABSTRACT] The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca[super]2+ distribution, compared with other fundamental ions, such as Na[super]+, K[super]+, and Mg[super]2+, were detected during the progression of ischemia. Furthermore, the Ca[super]2+ redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca[super]2+ ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca[super]2+ redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca[super]2+ ion movement. The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca2+ distribution, compared with other fundamental ions, such as Na+, K+, and Mg2+, were detected during the progression of ischemia. Furthermore, the Ca2+ redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2′-deoxyuridine 5′-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca2+ ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca2+ redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca2+ ion movement. The distribution and movement of elemental ions in biologic tissues is critical for many cellular processes. In contrast to chemical techniques for imaging the intracellular distribution of ions, however, techniques for imaging the distribution of ions across tissues are not well developed. We used time-of-flight secondary ion mass spectrometry (TOF-SIMS) to obtain nonlabeled high-resolution analytic images of ion distribution in ischemic retinal tissues. Marked changes in Ca(2+) distribution, compared with other fundamental ions, such as Na(+), K(+), and Mg(2+), were detected during the progression of ischemia. Furthermore, the Ca(2+) redistribution pattern correlated closely with TUNEL-positive (positive for terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end-labeling) cell death in ischemic retinas. After treatment with a calcium chelator, Ca(2+) ion redistribution was delayed, resulting in a decrease in TUNEL-positive cells. These results indicate that ischemia-induced Ca(2+) redistribution within retinal tissues is associated with the order of apoptotic cell death, which possibly explains the different susceptibility of various types of retinal cells to ischemia. Thus, the TOF-SIMS technique provides a tool for the study of intercellular communication by Ca(2+) ion movement. |
| Author | Ahn, Bum Ju Yu, Young Suk Kim, Jeong Hun Lee, Tae Geol Kim, Jin Hyoung Shon, Hyun Kyong Park, Jae-Hwan Moon, Dae Won Kim, Kyu-Won |
| AuthorAffiliation | Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea; † Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; and ‡ NanoBio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon, Korea |
| AuthorAffiliation_xml | – name: Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea; † Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; and ‡ NanoBio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon, Korea |
| Author_xml | – sequence: 1 givenname: Jin Hyoung surname: Kim fullname: Kim, Jin Hyoung organization: Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea – sequence: 2 givenname: Jeong Hun surname: Kim fullname: Kim, Jeong Hun organization: Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea – sequence: 3 givenname: Bum Ju surname: Ahn fullname: Ahn, Bum Ju organization: Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea – sequence: 4 givenname: Jae-Hwan surname: Park fullname: Park, Jae-Hwan organization: Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea – sequence: 5 givenname: Hyun Kyong surname: Shon fullname: Shon, Hyun Kyong organization: NanoBio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon, Korea – sequence: 6 givenname: Young Suk surname: Yu fullname: Yu, Young Suk organization: Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea – sequence: 7 givenname: Dae Won surname: Moon fullname: Moon, Dae Won organization: NanoBio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon, Korea – sequence: 8 givenname: Tae Geol surname: Lee fullname: Lee, Tae Geol email: tglee@kriss.re.kr organization: NanoBio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon, Korea – sequence: 9 givenname: Kyu-Won surname: Kim fullname: Kim, Kyu-Won email: qwonkim@plaza.snu.ac.kr organization: Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18227131$$D View this record in MEDLINE/PubMed |
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| Copyright | 2008 The Biophysical Society Copyright Biophysical Society May 15, 2008 Copyright © 2008, Biophysical Society |
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| DOI | 10.1529/biophysj.107.119800 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Address reprint requests to Kyu-Won Kim, Tel.: 82-2-880-6988; E-mail: qwonkim@plaza.snu.ac.kr; or Tae Geol Lee, E-mail: tglee@kriss.re.kr. Editor: Paul H. Axelsen. Jin Hyoung Kim and Jeong Hun Kim contributed equally to this work. |
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| SubjectTerms | Animals Biophysics Calcium Calcium - metabolism Cells Ions Ischemia - metabolism Ischemia - pathology Male Mice Mice, Inbred C57BL Retinal Vessels - metabolism Retinal Vessels - pathology Scientific imaging Spectrometry, Mass, Electrospray Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy, Imaging, Other Techniques Staining and Labeling Tissue Distribution |
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| Title | Label-Free Calcium Imaging in Ischemic Retinal Tissue by TOF-SIMS |
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