Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

• Published in: Cell Vol. 182; no. 3; pp. 734 - 743.e5
• Main Authors: Sun, Jing, Zhuang, Zhen, Zheng, Jian, Li, Kun, Wong, Roy Lok-Yin, Liu, Donglan, Huang, Jicheng, He, Jiangping, Zhu, Airu, Zhao, Jingxian, Li, Xiaobo, Xi, Yin, Chen, Rongchang, Alshukairi, Abeer N., Chen, Zhao, Zhang, Zhaoyong, Chen, Chunke, Huang, Xiaofang, Li, Fang, Lai, Xiaomin, Chen, Dingbin, Wen, Liyan, Zhuo, Jianfen, Zhang, Yanjun, Wang, Yanqun, Huang, Shuxiang, Dai, Jun, Shi, Yongxia, Zheng, Kui, Leidinger, Mariah R., Chen, Jiekai, Li, Yimin, Zhong, Nanshan, Meyerholz, David K., McCray, Paul B., Perlman, Stanley, Zhao, Jincun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2020
• Subjects: Adenoviridae; Angiotensin-Converting Enzyme 2; animal models; Animals; Betacoronavirus - immunology; Chlorocebus aethiops; Coronavirus Infections - pathology; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; COVID-19; COVID-19 infection; Disease Models, Animal; Drug Evaluation, Preclinical - methods; Female; Humans; Interferon-gamma - genetics; Interferon-gamma - metabolism; interferons; Lung - pathology; Lung - virology; lungs; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; mouse model; Pandemics - prevention & control; pathogenesis; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; pneumonia; Pneumonia, Viral - pathology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; polyinosinic-polycytidylic acid; rapid methods; Receptor, Interferon alpha-beta - genetics; Receptor, Interferon alpha-beta - metabolism; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; signal transduction; Specific Pathogen-Free Organisms; STAT1 Transcription Factor - genetics; STAT1 Transcription Factor - metabolism; T-lymphocytes; therapeutics; transactivators; Transduction, Genetic; Vaccination; vaccine; vaccines; Vero Cells; Viral Load; virulence; Virus Replication; viruses; weight loss; COVID-19; pathogenesis; SARS-CoV-2; therapeutics; vaccine; mouse model

COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV...