Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment - Sun, Jing; Zhuang, Zhen; Zheng, Jian; Li, Kun; Wong, Roy Lok-Yin; Liu, Donglan; Huang, Jicheng; He, Jiangping; Zhu, Airu; Zhao, Jingxian; Li, Xiaobo; Xi, Yin; et al. (Cell, 2020)
Keywords: Adenoviridae; Angiotensin-Converting Enzyme 2; animal models; Animals; Betacoronavirus - immunology; Chlorocebus aethiops; Coronavirus Infections - pathology; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; COVID-19; COVID-19 infection; Disease Models, Animal; Drug Evaluation, Preclinical - methods; Female; Humans; Interferon-gamma - genetics; Interferon-gamma - metabolism; interferons; Lung - pathology; Lung - virology; lungs; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; mouse model; Pandemics - prevention & control; pathogenesis; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; pneumonia; Pneumonia, Viral - pathology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; polyinosinic-polycytidylic acid; rapid methods; Receptor, Interferon alpha-beta - genetics; Receptor, Interferon alpha-beta - metabolism; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; signal transduction; Specific Pathogen-Free Organisms; STAT1 Transcription Factor - genetics; STAT1 Transcription Factor - metabolism; T-lymphocytes; therapeutics; transactivators; Transduction, Genetic; Vaccination; vaccine; vaccines; Vero Cells; Viral Load; virulence; Virus Replication; viruses; weight loss; COVID-19; pathogenesis; SARS-CoV-2; therapeutics; vaccine; mouse model