Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV...
Saved in:
| Published in | Cell Vol. 182; no. 3; pp. 734 - 743.e5 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.08.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines.
[Display omitted]
•Mice are sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction•Genetically deficient strains can be directly assessed without additional breeding•Mice useful for determining host factors necessary for optimal virus clearance•Useful for assessing efficacy of vaccines and therapies such as convalescent plasma
An adenoviral transduction-based mouse model that can be infected with SARS-CoV-2 provides a tool to understand host factors involved in viral infection and clearance as well as potential therapeutic modalities. |
|---|---|
| AbstractList | COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines.
•
Mice are sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction
•
Genetically deficient strains can be directly assessed without additional breeding
•
Mice useful for determining host factors necessary for optimal virus clearance
•
Useful for assessing efficacy of vaccines and therapies such as convalescent plasma
An adenoviral transduction-based mouse model that can be infected with SARS-CoV-2 provides a tool to understand host factors involved in viral infection and clearance as well as potential therapeutic modalities. COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines.COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines. COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines. [Display omitted] •Mice are sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction•Genetically deficient strains can be directly assessed without additional breeding•Mice useful for determining host factors necessary for optimal virus clearance•Useful for assessing efficacy of vaccines and therapies such as convalescent plasma An adenoviral transduction-based mouse model that can be infected with SARS-CoV-2 provides a tool to understand host factors involved in viral infection and clearance as well as potential therapeutic modalities. COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines. COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines. |
| Author | Li, Yimin Lai, Xiaomin Zhao, Jincun Shi, Yongxia Zheng, Jian Zhong, Nanshan Leidinger, Mariah R. Chen, Jiekai Zhao, Jingxian Huang, Shuxiang Chen, Zhao Chen, Chunke Huang, Xiaofang Huang, Jicheng Xi, Yin Alshukairi, Abeer N. Wang, Yanqun Liu, Donglan Zhu, Airu McCray, Paul B. Zhuo, Jianfen Zhang, Yanjun Li, Fang Perlman, Stanley Li, Xiaobo Li, Kun Chen, Rongchang Wen, Liyan Dai, Jun Sun, Jing Zheng, Kui Wong, Roy Lok-Yin Meyerholz, David K. He, Jiangping Chen, Dingbin Zhang, Zhaoyong Zhuang, Zhen |
| Author_xml | – sequence: 1 givenname: Jing surname: Sun fullname: Sun, Jing organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 2 givenname: Zhen surname: Zhuang fullname: Zhuang, Zhen organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 3 givenname: Jian surname: Zheng fullname: Zheng, Jian organization: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 4 givenname: Kun surname: Li fullname: Li, Kun organization: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 5 givenname: Roy Lok-Yin surname: Wong fullname: Wong, Roy Lok-Yin organization: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 6 givenname: Donglan surname: Liu fullname: Liu, Donglan organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 7 givenname: Jicheng surname: Huang fullname: Huang, Jicheng organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 8 givenname: Jiangping surname: He fullname: He, Jiangping organization: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou 510530, China – sequence: 9 givenname: Airu surname: Zhu fullname: Zhu, Airu organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 10 givenname: Jingxian surname: Zhao fullname: Zhao, Jingxian organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 11 givenname: Xiaobo surname: Li fullname: Li, Xiaobo organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 12 givenname: Yin surname: Xi fullname: Xi, Yin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 13 givenname: Rongchang surname: Chen fullname: Chen, Rongchang organization: Shenzhen Institute of Respiratory Disease, First Affiliated Hospital of South University of Science and Technology of China (Shenzhen People’s Hospital), Shenzhen, Guangdong, China – sequence: 14 givenname: Abeer N. surname: Alshukairi fullname: Alshukairi, Abeer N. organization: King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi Arabia – sequence: 15 givenname: Zhao surname: Chen fullname: Chen, Zhao organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 16 givenname: Zhaoyong surname: Zhang fullname: Zhang, Zhaoyong organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 17 givenname: Chunke surname: Chen fullname: Chen, Chunke organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 18 givenname: Xiaofang surname: Huang fullname: Huang, Xiaofang organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 19 givenname: Fang surname: Li fullname: Li, Fang organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 20 givenname: Xiaomin surname: Lai fullname: Lai, Xiaomin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 21 givenname: Dingbin surname: Chen fullname: Chen, Dingbin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 22 givenname: Liyan surname: Wen fullname: Wen, Liyan organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 23 givenname: Jianfen surname: Zhuo fullname: Zhuo, Jianfen organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 24 givenname: Yanjun surname: Zhang fullname: Zhang, Yanjun organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 25 givenname: Yanqun surname: Wang fullname: Wang, Yanqun organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 26 givenname: Shuxiang surname: Huang fullname: Huang, Shuxiang organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 27 givenname: Jun surname: Dai fullname: Dai, Jun organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 28 givenname: Yongxia surname: Shi fullname: Shi, Yongxia organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 29 givenname: Kui surname: Zheng fullname: Zheng, Kui organization: Guangzhou Customs District Technology Center, Guangzhou 510700, China – sequence: 30 givenname: Mariah R. surname: Leidinger fullname: Leidinger, Mariah R. organization: Department of Pathology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 31 givenname: Jiekai surname: Chen fullname: Chen, Jiekai organization: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou 510530, China – sequence: 32 givenname: Yimin surname: Li fullname: Li, Yimin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 33 givenname: Nanshan surname: Zhong fullname: Zhong, Nanshan organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China – sequence: 34 givenname: David K. surname: Meyerholz fullname: Meyerholz, David K. organization: Department of Pathology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 35 givenname: Paul B. surname: McCray fullname: McCray, Paul B. email: paul-mccray@uiowa.edu organization: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 36 givenname: Stanley orcidid: 0000-0003-4213-2354 surname: Perlman fullname: Perlman, Stanley email: stanley-perlman@uiowa.edu organization: Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242, USA – sequence: 37 givenname: Jincun surname: Zhao fullname: Zhao, Jincun email: zhaojincun@gird.cn organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32643603$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkUFPFTEUhRuDkQf6B1yYLl0w421npu0kxkSfgCQYXAALN02ncwf6Mq-Fdh4J_94OD4y6IK666DnfPTlnj-z44JGQtwxKBkx8WJUWx7HkwKEEUQKDF2TBoJVFzSTfIQuAlhdKyHqX7KW0AgDVNM0rsltxUVcCqgX5eYweo5lc8DQM1NAvMZh-vKcXCYfNSL-HHkc6hEiXZ5cnXwvW0h9mug5X2ZZcOqCXxlrnHwAH1Pienkc00xr99Jq8HMyY8M3ju08ujg7Pl9-K07Pjk-Xn08I2ik8F7xA6WSlTgRSsUYyJykLb1i32w1Ch6UGBMRXKhuXITWeH3nRcdIMSSjZttU8-bbk3m26Nvc2noxn1TXRrE-91ME7__ePdtb4Kd1pyVfMaMuD9IyCG2w2mSa9dmqs1HsMmaV7LnEyAbP9DyvncOszUd3_G-p3nqfssUFuBjSGliIO2bnooMqd0o2ag55n1Ss8H9DyzBqHzzNnK_7E-0Z81fdyaMI9x5zDqZB16i72LaCfdB_ec_RfMlb-b |
| CitedBy_id | crossref_primary_10_1038_s41467_021_21239_8 crossref_primary_10_1016_j_ebiom_2021_103762 crossref_primary_10_36233_0507_4088_47 crossref_primary_10_1016_j_bioactmat_2022_09_010 crossref_primary_10_1016_j_biopha_2021_112513 crossref_primary_10_3389_fneur_2022_882905 crossref_primary_10_1093_nsr_nwaa285 crossref_primary_10_1038_s41421_023_00536_0 crossref_primary_10_1021_acs_jmedchem_0c01929 crossref_primary_10_1016_j_jaip_2020_11_016 crossref_primary_10_1126_sciadv_adp2636 crossref_primary_10_1038_s41586_020_2708_8 crossref_primary_10_1093_ilar_ilab007 crossref_primary_10_1016_j_coviro_2021_03_009 crossref_primary_10_1038_s41423_023_01122_w crossref_primary_10_1093_immadv_ltab027 crossref_primary_10_1128_JVI_02477_20 crossref_primary_10_3389_fimmu_2022_821664 crossref_primary_10_36233_0507_4088_222 crossref_primary_10_1084_jem_20201748 crossref_primary_10_3389_fimmu_2022_891524 crossref_primary_10_1002_jmv_70049 crossref_primary_10_1073_pnas_2311913120 crossref_primary_10_1038_s41392_022_00954_8 crossref_primary_10_1038_s41586_022_04441_6 crossref_primary_10_3390_vaccines13030224 crossref_primary_10_1002_cti2_1259 crossref_primary_10_1007_s11914_023_00843_1 crossref_primary_10_1016_j_virs_2024_04_005 crossref_primary_10_2139_ssrn_3806768 crossref_primary_10_1177_03009858211058837 crossref_primary_10_1038_s41467_021_23166_0 crossref_primary_10_47184_ti_2020_03_02 crossref_primary_10_15407_visn2020_08_029 crossref_primary_10_3390_ijtm2010010 crossref_primary_10_7554_eLife_69866 crossref_primary_10_1128_JVI_00014_21 crossref_primary_10_1002_cti2_1260 crossref_primary_10_1016_j_cell_2020_09_050 crossref_primary_10_18273_saluduis_54_e_22057 crossref_primary_10_1038_s41467_021_21702_6 crossref_primary_10_1126_scitranslmed_abm7621 crossref_primary_10_3389_fimmu_2022_914167 crossref_primary_10_3390_v16111794 crossref_primary_10_3390_pathogens12010020 crossref_primary_10_1126_sciimmunol_abe8063 crossref_primary_10_1016_j_bbe_2022_04_005 crossref_primary_10_3389_fimmu_2022_871828 crossref_primary_10_1128_spectrum_01100_23 crossref_primary_10_1007_s00251_022_01261_w crossref_primary_10_3390_microorganisms11020431 crossref_primary_10_1038_s41392_021_00849_0 crossref_primary_10_3389_fimmu_2024_1440314 crossref_primary_10_1126_sciimmunol_abo0535 crossref_primary_10_3390_ph16050767 crossref_primary_10_2147_PRBM_S360772 crossref_primary_10_1007_s11882_021_00993_1 crossref_primary_10_1016_j_onehlt_2024_100744 crossref_primary_10_1002_mco2_206 crossref_primary_10_1016_j_jece_2020_104973 crossref_primary_10_1128_mbio_03693_24 crossref_primary_10_1016_j_matpr_2021_01_318 crossref_primary_10_1126_sciadv_adn9519 crossref_primary_10_1002_ame2_12155 crossref_primary_10_3389_fcimb_2023_1203625 crossref_primary_10_1002_ame2_12278 crossref_primary_10_1038_s41467_022_32957_y crossref_primary_10_1080_14760584_2022_2071264 crossref_primary_10_1038_s41392_024_01753_z crossref_primary_10_3390_cells9112508 crossref_primary_10_1016_j_medj_2020_11_002 crossref_primary_10_1128_mBio_02648_20 crossref_primary_10_1007_s11914_023_00842_2 crossref_primary_10_1016_j_coviro_2021_11_015 crossref_primary_10_1146_annurev_pharmtox_121120_012309 crossref_primary_10_1016_j_jmb_2021_166945 crossref_primary_10_3390_su122410369 crossref_primary_10_34133_2022_9819154 crossref_primary_10_1177_0300985820974005 crossref_primary_10_1093_nsr_nwaa291 crossref_primary_10_1016_j_fmre_2021_03_001 crossref_primary_10_1084_jem_20202187 crossref_primary_10_4049_jimmunol_2001451 crossref_primary_10_3390_covid1030051 crossref_primary_10_1016_j_ebiom_2021_103291 crossref_primary_10_1038_s41422_022_00775_y crossref_primary_10_1016_j_jbc_2023_104668 crossref_primary_10_1124_pharmrev_120_000285 crossref_primary_10_1038_s41467_021_21171_x crossref_primary_10_1016_j_virol_2021_02_003 crossref_primary_10_1371_journal_ppat_1010782 crossref_primary_10_15407_ubj92_06_005 crossref_primary_10_1126_sciimmunol_abl4509 crossref_primary_10_3389_fmicb_2021_651403 crossref_primary_10_1038_s41591_021_01282_0 crossref_primary_10_1016_j_celrep_2020_108488 crossref_primary_10_1038_s42003_023_04447_4 crossref_primary_10_1038_s41392_024_01917_x crossref_primary_10_1038_s41598_022_21223_2 crossref_primary_10_1165_rcmb_2020_0354OC crossref_primary_10_2147_JBM_S397722 crossref_primary_10_3390_v12101172 crossref_primary_10_1016_j_xpro_2020_100169 crossref_primary_10_1016_j_patter_2021_100247 crossref_primary_10_1111_caim_12631 crossref_primary_10_1021_acs_jproteome_0c00372 crossref_primary_10_1016_j_scr_2020_102116 crossref_primary_10_1038_s41467_020_20608_z crossref_primary_10_1080_17460441_2022_1995352 crossref_primary_10_1038_s41422_020_00405_5 crossref_primary_10_1016_j_xcrm_2020_100164 crossref_primary_10_52538_iduhes_1162455 crossref_primary_10_3389_fmed_2021_684151 crossref_primary_10_1038_s41392_022_01087_8 crossref_primary_10_1186_s40779_020_00296_y crossref_primary_10_1136_thoraxjnl_2021_217650 crossref_primary_10_1038_s41586_022_05344_2 crossref_primary_10_1371_journal_pbio_3001209 crossref_primary_10_1152_ajplung_00305_2021 crossref_primary_10_1371_journal_ppat_1009427 crossref_primary_10_1186_s12985_023_02031_0 crossref_primary_10_1016_j_jbior_2020_100741 crossref_primary_10_1038_s41467_024_50133_2 crossref_primary_10_1038_s41421_021_00302_0 crossref_primary_10_2478_fzm_2023_0019 crossref_primary_10_1038_s41467_020_20501_9 crossref_primary_10_3390_ijms23126394 crossref_primary_10_1038_s41586_020_2798_3 crossref_primary_10_1016_j_virs_2022_05_006 crossref_primary_10_32415_jscientia_2021_7_5_28_59 crossref_primary_10_1038_s41590_024_02072_9 crossref_primary_10_1007_s10668_021_01798_y crossref_primary_10_1093_femsre_fuac042 crossref_primary_10_1128_jvi_00790_23 crossref_primary_10_2217_fvl_2021_0062 crossref_primary_10_1016_j_ebiom_2024_105248 crossref_primary_10_3390_vaccines10111807 crossref_primary_10_1165_rcmb_2020_0456ED crossref_primary_10_1016_j_mayocp_2021_02_008 crossref_primary_10_1038_s41467_023_43447_0 crossref_primary_10_1038_s41419_023_05817_w crossref_primary_10_1186_s42826_022_00127_2 crossref_primary_10_3389_fmicb_2024_1404312 crossref_primary_10_1016_j_xcrm_2021_100420 crossref_primary_10_3390_cells11193027 crossref_primary_10_1073_pnas_2118312119 crossref_primary_10_1016_j_ebiom_2024_105361 crossref_primary_10_1371_journal_ppat_1011728 crossref_primary_10_1073_pnas_2009875117 crossref_primary_10_3389_fimmu_2023_1284148 crossref_primary_10_1016_j_molmed_2021_09_009 crossref_primary_10_1016_j_virs_2022_12_007 crossref_primary_10_1128_mBio_03372_20 crossref_primary_10_1080_22221751_2022_2056524 crossref_primary_10_1002_rmv_2196 crossref_primary_10_1038_s41392_022_01048_1 crossref_primary_10_1021_acs_jmedchem_0c00626 crossref_primary_10_1016_j_vetmic_2023_109848 crossref_primary_10_1016_j_xcrm_2023_100918 crossref_primary_10_1038_s41467_023_40076_5 crossref_primary_10_1080_08830185_2022_2089666 crossref_primary_10_1016_j_antiviral_2022_105345 crossref_primary_10_1016_j_ooc_2023_100030 crossref_primary_10_1038_s41598_024_80498_9 crossref_primary_10_3389_fmicb_2021_770935 crossref_primary_10_1073_pnas_2202820120 crossref_primary_10_1038_s41467_021_26239_2 crossref_primary_10_1002_mco2_115 crossref_primary_10_3892_etm_2021_10414 crossref_primary_10_1002_jmv_29782 crossref_primary_10_1073_pnas_2018030117 crossref_primary_10_3389_fddsv_2022_899587 crossref_primary_10_1016_j_it_2020_10_004 crossref_primary_10_1016_j_jare_2022_08_008 crossref_primary_10_1016_j_phymed_2021_153874 crossref_primary_10_1021_acsnano_0c06109 crossref_primary_10_1002_adma_202107781 crossref_primary_10_1007_s00430_022_00735_8 crossref_primary_10_1172_JCI147973 crossref_primary_10_1038_s41577_020_0402_6 crossref_primary_10_1371_journal_ppat_1009758 crossref_primary_10_1021_acschembio_0c00840 crossref_primary_10_1134_S0026893322050065 crossref_primary_10_1038_s41591_021_01386_7 crossref_primary_10_1002_mco2_98 crossref_primary_10_2174_1872208316666220124101611 crossref_primary_10_7554_eLife_66522 crossref_primary_10_1007_s11248_021_00249_8 crossref_primary_10_1038_s41421_021_00320_y crossref_primary_10_1111_bph_15266 crossref_primary_10_1038_s41422_021_00595_6 crossref_primary_10_1084_jem_20201241 crossref_primary_10_3390_vaccines9101082 crossref_primary_10_1002_jmv_26720 crossref_primary_10_1093_gbe_evac100 crossref_primary_10_1186_s13020_022_00598_4 crossref_primary_10_1038_s41467_020_19891_7 crossref_primary_10_4110_in_2021_21_e8 crossref_primary_10_1016_j_bbih_2024_100905 crossref_primary_10_3390_vaccines10101621 crossref_primary_10_1016_j_isci_2021_103670 crossref_primary_10_1016_j_drudis_2021_12_014 crossref_primary_10_4110_in_2021_21_e4 crossref_primary_10_3390_v13081498 crossref_primary_10_1016_j_eng_2020_10_003 crossref_primary_10_3389_fimmu_2023_1052141 crossref_primary_10_3389_fimmu_2022_925922 crossref_primary_10_3390_microorganisms9040868 crossref_primary_10_1002_advs_202104333 crossref_primary_10_1371_journal_ppat_1012116 crossref_primary_10_1515_dx_2020_0161 crossref_primary_10_1099_jgv_0_002039 crossref_primary_10_1080_01902148_2024_2428939 crossref_primary_10_1126_sciadv_adg3277 crossref_primary_10_1016_j_isci_2022_103967 crossref_primary_10_1093_nsr_nwac176 crossref_primary_10_1016_j_isci_2021_102699 crossref_primary_10_1038_s42003_024_06805_2 crossref_primary_10_1016_j_immuni_2021_01_017 crossref_primary_10_1016_j_ymthe_2022_01_010 crossref_primary_10_3390_v13101993 crossref_primary_10_1007_s11357_021_00444_9 crossref_primary_10_1016_j_bbadis_2021_166260 crossref_primary_10_1073_pnas_2102957118 crossref_primary_10_1016_j_smim_2021_101505 crossref_primary_10_1080_22221751_2024_2353302 crossref_primary_10_1016_j_celrep_2021_109838 crossref_primary_10_1038_s41392_021_00604_5 crossref_primary_10_1177_20458940211015799 crossref_primary_10_3389_fmicb_2021_626553 crossref_primary_10_1007_s10916_021_01757_0 crossref_primary_10_1016_j_ejphar_2022_175051 crossref_primary_10_3389_fphar_2020_600369 crossref_primary_10_7759_cureus_16746 crossref_primary_10_1016_j_molimm_2022_06_007 crossref_primary_10_3390_v12080880 crossref_primary_10_1371_journal_ppat_1009723 crossref_primary_10_3389_fimmu_2022_819058 crossref_primary_10_1002_jmv_27718 crossref_primary_10_3389_fcell_2021_683619 crossref_primary_10_1002_wnan_1857 crossref_primary_10_1016_j_cell_2020_06_011 crossref_primary_10_1038_s41467_021_22580_8 crossref_primary_10_1073_pnas_2317026121 crossref_primary_10_1093_bib_bbaa329 crossref_primary_10_3389_fimmu_2022_954121 crossref_primary_10_1016_j_chom_2020_12_010 crossref_primary_10_1038_s41596_020_00403_2 crossref_primary_10_1016_j_vaccine_2021_06_028 crossref_primary_10_3390_vaccines9080850 crossref_primary_10_1016_j_pharmthera_2021_107931 crossref_primary_10_1002_advs_202303366 crossref_primary_10_1038_s41467_024_45043_2 crossref_primary_10_1128_jvi_01245_22 crossref_primary_10_3389_fimmu_2022_1007080 crossref_primary_10_3389_fimmu_2023_1240419 crossref_primary_10_3390_v17010100 crossref_primary_10_1002_adbi_202200007 crossref_primary_10_1016_j_apsb_2021_04_023 crossref_primary_10_1038_s41392_021_00610_7 crossref_primary_10_1002_mco2_70008 crossref_primary_10_1172_JCI154987 crossref_primary_10_3390_cells10112949 crossref_primary_10_3389_fimmu_2022_1081047 crossref_primary_10_4103_ijmr_IJMR_3215_20 crossref_primary_10_1016_j_nantod_2022_101468 crossref_primary_10_1080_22221751_2020_1838955 crossref_primary_10_3389_fcell_2023_1238027 crossref_primary_10_3389_fcell_2021_578825 crossref_primary_10_1038_s41564_022_01235_4 crossref_primary_10_1073_pnas_2025373118 crossref_primary_10_30802_AALAS_CM_21_000046 crossref_primary_10_1177_1073858420956905 crossref_primary_10_1371_journal_ppat_1009392 crossref_primary_10_3390_v14071507 crossref_primary_10_1128_mbio_03136_22 crossref_primary_10_15212_ZOONOSES_2023_0060 crossref_primary_10_1038_s41392_020_00269_6 crossref_primary_10_3389_fvets_2020_596391 crossref_primary_10_1007_s13337_020_00637_4 crossref_primary_10_1146_annurev_immunol_101921_050835 crossref_primary_10_1038_s41586_022_04630_3 crossref_primary_10_1002_jmv_28948 crossref_primary_10_1038_s41467_021_25903_x crossref_primary_10_1172_jci_insight_163471 crossref_primary_10_1016_j_rmed_2021_106355 crossref_primary_10_22490_24629448_4191 crossref_primary_10_1016_j_cmet_2022_01_008 crossref_primary_10_1038_s41577_020_00480_0 crossref_primary_10_1177_03009858221096502 crossref_primary_10_1016_j_immuni_2020_07_005 crossref_primary_10_1038_s41392_021_00634_z crossref_primary_10_15252_emmm_202114122 crossref_primary_10_1128_cmr_00119_23 crossref_primary_10_3389_fimmu_2022_993754 crossref_primary_10_30802_AALAS_CM_21_000031 crossref_primary_10_1093_nar_gkad450 crossref_primary_10_1038_s41586_021_03461_y crossref_primary_10_3390_vaccines12090966 crossref_primary_10_1073_pnas_2026207118 crossref_primary_10_1002_jmv_27747 crossref_primary_10_1128_mBio_00970_21 crossref_primary_10_3389_fimmu_2022_811802 crossref_primary_10_3390_pathogens12020301 crossref_primary_10_1038_s41592_022_01447_w crossref_primary_10_1038_s41467_022_30222_w crossref_primary_10_3389_fimmu_2020_595739 crossref_primary_10_1002_pd_5985 crossref_primary_10_1080_21505594_2024_2316438 crossref_primary_10_51335_organoid_2021_1_e10 crossref_primary_10_1038_s41421_021_00295_w crossref_primary_10_1002_eji_202048984 crossref_primary_10_1002_int_22449 crossref_primary_10_1016_j_ijid_2020_10_074 crossref_primary_10_3390_pathogens10080940 crossref_primary_10_1016_j_ebiom_2021_103381 crossref_primary_10_3390_vaccines9080881 crossref_primary_10_1128_jvi_02323_24 crossref_primary_10_1016_j_celrep_2023_113653 crossref_primary_10_1038_s41422_021_00570_1 crossref_primary_10_2139_ssrn_3800087 crossref_primary_10_3390_v14061127 crossref_primary_10_1002_cyto_a_24285 crossref_primary_10_1038_s41586_022_04690_5 crossref_primary_10_1172_JCI147201 crossref_primary_10_1016_j_chom_2020_09_016 crossref_primary_10_1002_ajh_26531 crossref_primary_10_1128_jvi_01510_23 crossref_primary_10_1016_j_xpro_2021_100873 crossref_primary_10_1038_s41577_020_00428_4 crossref_primary_10_3390_vaccines9050466 crossref_primary_10_30802_AALAS_CM_21_000011 crossref_primary_10_1007_s11655_024_3909_z crossref_primary_10_3389_fimmu_2021_789317 crossref_primary_10_1016_j_virol_2021_08_014 crossref_primary_10_1038_s41577_021_00656_2 crossref_primary_10_3390_v14010011 |
| Cites_doi | 10.1038/nmicrobiol.2016.226 10.1038/nmeth.1923 10.2353/ajpath.2008.071060 10.1038/sj.gt.3301197 10.1016/S0002-9610(05)80589-6 10.1016/j.immuni.2016.05.006 10.1038/s41586-020-2012-7 10.1073/pnas.1619109114 10.1038/nm990 10.1126/science.abb7015 10.1073/pnas.1323279111 10.1016/j.cell.2020.06.011 10.1371/journal.ppat.0030005 10.1002/ame2.12108 10.1016/j.immuni.2019.03.025 10.1128/JVI.79.23.14614-14621.2005 10.1002/jcb.240400208 10.1073/pnas.1510830112 10.1371/journal.ppat.1000849 10.1016/j.chom.2020.03.023 10.1016/S0140-6736(20)30183-5 10.1038/s41374-018-0057-0 10.1089/omi.2011.0118 10.1128/JVI.02272-08 10.1056/NEJMoa2007016 10.1084/jem.20200653 10.1093/cid/ciaa325 10.1093/infdis/jiv499 10.1038/s41422-020-0282-0 10.1038/ng0994-42 10.1128/JVI.02012-06 10.1186/s13059-014-0550-8 10.1186/1471-2105-12-480 10.1128/JVI.01049-10 10.1186/1471-2105-12-323 10.1371/journal.pmed.0030525 10.1172/JCI137244 10.1128/JVI.03427-14 |
| ContentType | Journal Article |
| Copyright | 2020 Elsevier Inc. Copyright © 2020 Elsevier Inc. All rights reserved. 2020 Elsevier Inc. 2020 Elsevier Inc. |
| Copyright_xml | – notice: 2020 Elsevier Inc. – notice: Copyright © 2020 Elsevier Inc. All rights reserved. – notice: 2020 Elsevier Inc. 2020 Elsevier Inc. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.cell.2020.06.010 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic AGRICOLA MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1097-4172 |
| EndPage | 743.e5 |
| ExternalDocumentID | PMC7284240 32643603 10_1016_j_cell_2020_06_010 S0092867420307418 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIEHS NIH HHS grantid: P30 ES005605 – fundername: NIAID NIH HHS grantid: R01 AI129269 – fundername: NIAID NIH HHS grantid: P01 AI060699 – fundername: NIDDK NIH HHS grantid: P30 DK054759 |
| GroupedDBID | --- --K -DZ -ET -~X 0R~ 0WA 1RT 1~5 29B 2FS 2WC 3EH 4.4 457 4G. 53G 5GY 5RE 62- 6J9 7-5 85S AACTN AAEDW AAFTH AAFWJ AAIAV AAKRW AAKUH AALRI AAUCE AAVLU AAXUO ABCQX ABJNI ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACNCT ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGHSJ AGKMS AHHHB AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS F5P FCP FDB FIRID HH5 IH2 IHE IXB J1W JIG K-O KOO KQ8 L7B LX5 M3Z M41 N9A O-L O9- OK1 P2P RCE RNS ROL RPZ SCP SDG SDP SES SSZ TAE TN5 TR2 TWZ UKR UPT VQA WH7 WQ6 YZZ ZA5 ZCA .-4 .55 .GJ .HR 1CY 1VV 2KS 3O- 5VS 6TJ 9M8 AAEDT AAHBH AAIKJ AAMRU AAQFI AAQXK AAYJJ AAYWO AAYXX ABDGV ABDPE ABEFU ABWVN ACRPL ACVFH ADCNI ADMUD ADNMO ADVLN ADXHL AETEA AEUPX AFPUW AGCQF AGHFR AGQPQ AI. AIDAL AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION EJD FEDTE FGOYB G-2 HVGLF HZ~ H~9 MVM OHT OMK OZT PUQ R2- RIG UBW UHB VH1 X7M YYP YYQ ZGI ZHY ZKB ZY4 CGR CUY CVF ECM EFKBS EIF NPM 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c582t-2be0b738a30761581163c09949edff3ead080aa3e7516035bcfdab26bf8687593 |
| IEDL.DBID | IXB |
| ISSN | 0092-8674 1097-4172 |
| IngestDate | Thu Aug 21 18:08:32 EDT 2025 Fri Jul 11 04:41:02 EDT 2025 Fri Jul 11 00:31:54 EDT 2025 Mon Jul 21 06:06:25 EDT 2025 Tue Jul 01 02:17:06 EDT 2025 Thu Apr 24 23:11:12 EDT 2025 Fri Feb 23 02:47:28 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | COVID-19 pathogenesis SARS-CoV-2 therapeutics vaccine mouse model |
| Language | English |
| License | Copyright © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c582t-2be0b738a30761581163c09949edff3ead080aa3e7516035bcfdab26bf8687593 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead Contact These authors contributed equally |
| ORCID | 0000-0003-4213-2354 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7284240 |
| PMID | 32643603 |
| PQID | 2422009200 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7284240 proquest_miscellaneous_2477616079 proquest_miscellaneous_2422009200 pubmed_primary_32643603 crossref_citationtrail_10_1016_j_cell_2020_06_010 crossref_primary_10_1016_j_cell_2020_06_010 elsevier_sciencedirect_doi_10_1016_j_cell_2020_06_010 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-06 |
| PublicationDateYYYYMMDD | 2020-08-06 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-06 day: 06 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell |
| PublicationTitleAlternate | Cell |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Kim, Kim, Kim, Kim, Park, Yu, Chang, Kim, Lee, Casel (bib18) 2020; 27 Chen, Wu, Guo, Cao, Huang, Wang, Wang, Zhang, Chen, Yu (bib7) 2020; 130 Yu, Qi, Xu, Li, Liu, Liu, Bao, Deng, Gao, Xiang (bib40) 2020; 3 Zhou, Yang, Wang, Hu, Zhang, Zhang, Si, Zhu, Li, Huang (bib45) 2020; 579 Bao, Deng, Huang, Gao, Liu, Ren, Wei, Yu, Xu, Qi (bib3) 2020; 2020 Risso, Schwartz, Sherlock, Dudoit (bib31) 2011; 12 Agrawal, Garron, Tao, Peng, Wakamiya, Chan, Couch, Tseng (bib1) 2015; 89 Nagata, Iwata, Hasegawa, Fukushi, Harashima, Sato, Saijo, Taguchi, Morikawa, Sata (bib28) 2008; 172 Crystal, McElvaney, Rosenfeld, Chu, Mastrangeli, Hay, Brody, Jaffe, Eissa, Danel (bib9) 1994; 8 Meyerholz, Beck (bib26) 2018; 98 Cockrell, Yount, Scobey, Jensen, Douglas, Beall, Tang, Marasco, Heise, Baric (bib8) 2016; 2 Zhao, Zhao, Mangalam, Channappanavar, Fett, Meyerholz, Agnihothram, Baric, David, Perlman (bib44) 2016; 44 Love, Huber, Anders (bib24) 2014; 15 Boudewijns, Thibaut, Kaptein, Li, Vergote, Seldeslachts, De Keyzer, Sharma, Jansen, Weyenbergh (bib5) 2020 Langmead, Salzberg (bib19) 2012; 9 Yang, Deng, Tong, Liu, Zhang, Zhu, Gao, Huang, Liu, Ma (bib36) 2007; 57 Zhao, Li, Wohlford-Lenane, Agnihothram, Fett, Zhao, Gale, Baric, Enjuanes, Gallagher (bib43) 2014; 111 Prokunina-Olsson, Alphonse, Dickenson, Durbin, Glenn, Hartmann, Kotenko, Lazear, O’Brien, Odendall (bib30) 2020; 217 Grein, Ohmagari, Shin, Diaz, Asperges, Castagna, Feldt, Green, Green, Lescure (bib13) 2020 McCray, Pewe, Wohlford-Lenane, Hickey, Manzel, Shi, Netland, Jia, Halabi, Sigmund (bib25) 2007; 81 Anderson, Haskell, Xia, Roessler, Davidson (bib2) 2000; 7 Deming, Sheahan, Heise, Yount, Davis, Sims, Suthar, Harkema, Whitmore, Pickles (bib10) 2006; 3 Jia, Look, Shi, Hickey, Pewe, Netland, Farzan, Wohlford-Lenane, Perlman, McCray (bib17) 2005; 79 Chan, Zhang, Yuan, Poon, Chan, Lee, Chan, Fan, Tsoi, Wen (bib6) 2020 Wang, Cao, Zhang, Yang, Liu, Xu, Shi, Hu, Zhong, Xiao (bib35) 2020; 30 Yu, Wang, Han, He (bib39) 2012; 16 Nabel (bib27) 2004; 10 Li, Dewey (bib21) 2011; 12 Pascal, Coleman, Mujica, Kamat, Badithe, Fairhurst, Hunt, Strein, Berrebi, Sisk (bib29) 2015; 112 Yin, Mao, Luan, Shen, Shen, Su, Wang, Zhou, Zhao, Gao (bib37) 2020 Deuel, Silverman, Kawahara (bib11) 1988; 1 Lazear, Schoggins, Diamond (bib20) 2019; 50 Roberts, Deming, Paddock, Cheng, Yount, Vogel, Herman, Sheahan, Heise, Genrich (bib32) 2007; 3 Wahl, Wong, McCartney-Francis (bib34) 1989; 40 Frieman, Chen, Morrison, Whitmore, Funkhouser, Ward, Lamirande, Roberts, Heise, Subbarao, Baric (bib12) 2010; 6 Li, Wohlford-Lenane, Perlman, Zhao, Jewell, Reznikov, Gibson-Corley, Meyerholz, McCray (bib22) 2016; 213 Li, Wohlford-Lenane, Channappanavar, Park, Earnest, Bair, Bates, Brogden, Flaherty, Gallagher (bib23) 2017; 114 Shi, Wen, Zhong, Yang, Wang, Huang, Liu, He, Shuai, Sun (bib33) 2020; 368 Yoshikawa, Yoshikawa, Hill, Huang, Watts, Makino, Milligan, Chan, Peters, Tseng (bib38) 2009; 83 Bennett, Schultz (bib4) 1993; 166 Hassan, Case, Winkler, Thackray, Kafai, Bailey, McCune, Fox, Chen, Al Soussi (bib14) 2020; 182 Huang, Wang, Li, Ren, Zhao, Hu, Zhang, Fan, Xu, Gu (bib15) 2020; 395 Hutchins, Jauch, Dyla, Miranda-Saavedra (bib16) 2014; 3 Zhao, Zhao, Perlman (bib41) 2010; 84 Zhao (10.1016/j.cell.2020.06.010_bib44) 2016; 44 Li (10.1016/j.cell.2020.06.010_bib23) 2017; 114 Prokunina-Olsson (10.1016/j.cell.2020.06.010_bib30) 2020; 217 Li (10.1016/j.cell.2020.06.010_bib21) 2011; 12 Agrawal (10.1016/j.cell.2020.06.010_bib1) 2015; 89 Kim (10.1016/j.cell.2020.06.010_bib18) 2020; 27 Jia (10.1016/j.cell.2020.06.010_bib17) 2005; 79 Pascal (10.1016/j.cell.2020.06.010_bib29) 2015; 112 Boudewijns (10.1016/j.cell.2020.06.010_bib5) 2020 McCray (10.1016/j.cell.2020.06.010_bib25) 2007; 81 Lazear (10.1016/j.cell.2020.06.010_bib20) 2019; 50 Deuel (10.1016/j.cell.2020.06.010_bib11) 1988; 1 Deming (10.1016/j.cell.2020.06.010_bib10) 2006; 3 Langmead (10.1016/j.cell.2020.06.010_bib19) 2012; 9 Yoshikawa (10.1016/j.cell.2020.06.010_bib38) 2009; 83 Bao (10.1016/j.cell.2020.06.010_bib3) 2020; 2020 Crystal (10.1016/j.cell.2020.06.010_bib9) 1994; 8 Yu (10.1016/j.cell.2020.06.010_bib39) 2012; 16 Yu (10.1016/j.cell.2020.06.010_bib40) 2020; 3 Zhao (10.1016/j.cell.2020.06.010_bib43) 2014; 111 Love (10.1016/j.cell.2020.06.010_bib24) 2014; 15 Zhou (10.1016/j.cell.2020.06.010_bib45) 2020; 579 Cockrell (10.1016/j.cell.2020.06.010_bib8) 2016; 2 Nagata (10.1016/j.cell.2020.06.010_bib28) 2008; 172 Risso (10.1016/j.cell.2020.06.010_bib31) 2011; 12 Meyerholz (10.1016/j.cell.2020.06.010_bib26) 2018; 98 Li (10.1016/j.cell.2020.06.010_bib22) 2016; 213 Anderson (10.1016/j.cell.2020.06.010_bib2) 2000; 7 Grein (10.1016/j.cell.2020.06.010_bib13) 2020 Frieman (10.1016/j.cell.2020.06.010_bib12) 2010; 6 Chan (10.1016/j.cell.2020.06.010_bib6) 2020 Roberts (10.1016/j.cell.2020.06.010_bib32) 2007; 3 Yang (10.1016/j.cell.2020.06.010_bib36) 2007; 57 Hutchins (10.1016/j.cell.2020.06.010_bib16) 2014; 3 Zhao (10.1016/j.cell.2020.06.010_bib41) 2010; 84 Nabel (10.1016/j.cell.2020.06.010_bib27) 2004; 10 Shi (10.1016/j.cell.2020.06.010_bib33) 2020; 368 Huang (10.1016/j.cell.2020.06.010_bib15) 2020; 395 Wang (10.1016/j.cell.2020.06.010_bib35) 2020; 30 Chen (10.1016/j.cell.2020.06.010_bib7) 2020; 130 Wahl (10.1016/j.cell.2020.06.010_bib34) 1989; 40 Yin (10.1016/j.cell.2020.06.010_bib37) 2020 Bennett (10.1016/j.cell.2020.06.010_bib4) 1993; 166 Hassan (10.1016/j.cell.2020.06.010_bib14) 2020; 182 |
| References_xml | – volume: 30 start-page: 269 year: 2020 end-page: 271 ident: bib35 article-title: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro publication-title: Cell Res. – volume: 12 start-page: 323 year: 2011 ident: bib21 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinformatics – volume: 368 start-page: 1016 year: 2020 end-page: 1020 ident: bib33 article-title: Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 publication-title: Science – volume: 12 start-page: 480 year: 2011 ident: bib31 article-title: GC-content normalization for RNA-Seq data publication-title: BMC Bioinformatics – volume: 130 start-page: 2620 year: 2020 end-page: 2629 ident: bib7 article-title: Clinical and immunological features of severe and moderate coronavirus disease 2019 publication-title: J. Clin. Invest. – volume: 579 start-page: 270 year: 2020 end-page: 273 ident: bib45 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature – volume: 27 start-page: 704 year: 2020 end-page: 709.e2 ident: bib18 article-title: Infection and Rapid Transmission of SARS-CoV-2 in Ferrets publication-title: Cell Host Microbe – year: 2020 ident: bib13 article-title: Compassionate Use of Remdesivir for Patients with Severe Covid-19 publication-title: New Engl J Med. – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: bib19 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods – volume: 3 start-page: e525 year: 2006 ident: bib10 article-title: Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants publication-title: PLoS Med. – volume: 3 start-page: e5 year: 2007 ident: bib32 article-title: A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice publication-title: PLoS Pathog. – volume: 8 start-page: 42 year: 1994 end-page: 51 ident: bib9 article-title: Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis publication-title: Nat. Genet. – volume: 1 start-page: 213 year: 1988 end-page: 217 ident: bib11 article-title: Platelet-derived growth factor: a multifunctional regulator of normal and abnormal cell growth publication-title: Biofactors – volume: 3 start-page: 1 year: 2014 ident: bib16 article-title: glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data publication-title: Cell Regen. (Lond.) – volume: 182 start-page: 744 year: 2020 end-page: 753 ident: bib14 article-title: A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies publication-title: Cell – volume: 89 start-page: 3659 year: 2015 end-page: 3670 ident: bib1 article-title: Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease publication-title: J. Virol. – volume: 213 start-page: 712 year: 2016 end-page: 722 ident: bib22 article-title: Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4 publication-title: J. Infect. Dis. – volume: 81 start-page: 813 year: 2007 end-page: 821 ident: bib25 article-title: Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus publication-title: J. Virol. – volume: 16 start-page: 284 year: 2012 end-page: 287 ident: bib39 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS – volume: 50 start-page: 907 year: 2019 end-page: 923 ident: bib20 article-title: Shared and Distinct Functions of Type I and Type III Interferons publication-title: Immunity – volume: 395 start-page: 497 year: 2020 end-page: 506 ident: bib15 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet – volume: 40 start-page: 193 year: 1989 end-page: 199 ident: bib34 article-title: Role of growth factors in inflammation and repair publication-title: J. Cell. Biochem. – volume: 2020 start-page: 7 year: 2020 ident: bib3 article-title: The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice publication-title: Nature – volume: 84 start-page: 9318 year: 2010 end-page: 9325 ident: bib41 article-title: T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice publication-title: J. Virol. – year: 2020 ident: bib5 article-title: STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters publication-title: bioRxiv – volume: 15 start-page: 550 year: 2014 ident: bib24 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. – volume: 79 start-page: 14614 year: 2005 end-page: 14621 ident: bib17 article-title: ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia publication-title: J. Virol. – volume: 112 start-page: 8738 year: 2015 end-page: 8743 ident: bib29 article-title: Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection publication-title: Proc. Natl. Acad. Sci. USA – volume: 217 start-page: e20200653 year: 2020 ident: bib30 article-title: COVID-19 and emerging viral infections: The case for interferon lambda publication-title: J. Exp. Med. – volume: 172 start-page: 1625 year: 2008 end-page: 1637 ident: bib28 article-title: Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice publication-title: Am. J. Pathol. – volume: 10 start-page: 135 year: 2004 end-page: 141 ident: bib27 article-title: Genetic, cellular and immune approaches to disease therapy: past and future publication-title: Nat. Med. – start-page: eabc1560 year: 2020 ident: bib37 article-title: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir publication-title: Science – volume: 83 start-page: 5451 year: 2009 end-page: 5465 ident: bib38 article-title: Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2 publication-title: J. Virol. – start-page: ciaa325 year: 2020 ident: bib6 article-title: Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility publication-title: Clin Infect Dis. – volume: 7 start-page: 1034 year: 2000 end-page: 1038 ident: bib2 article-title: A simple method for the rapid generation of recombinant adenovirus vectors publication-title: Gene Ther. – volume: 2 start-page: 16226 year: 2016 ident: bib8 article-title: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome publication-title: Nat. Microbiol. – volume: 6 start-page: e1000849 year: 2010 ident: bib12 article-title: SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism publication-title: PLoS Pathog. – volume: 44 start-page: 1379 year: 2016 end-page: 1391 ident: bib44 article-title: Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses publication-title: Immunity – volume: 57 start-page: 450 year: 2007 end-page: 459 ident: bib36 article-title: Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection publication-title: Comp. Med. – volume: 3 start-page: 93 year: 2020 end-page: 97 ident: bib40 article-title: Age-related rhesus macaque models of COVID-19 publication-title: Animal Model Exp Med – volume: 166 start-page: 74 year: 1993 end-page: 81 ident: bib4 article-title: Growth factors and wound healing: Part II. Role in normal and chronic wound healing publication-title: Am. J. Surg. – volume: 98 start-page: 844 year: 2018 end-page: 855 ident: bib26 article-title: Principles and approaches for reproducible scoring of tissue stains in research publication-title: Lab. Invest. – volume: 111 start-page: 4970 year: 2014 end-page: 4975 ident: bib43 article-title: Rapid generation of a mouse model for Middle East respiratory syndrome publication-title: Proc. Natl. Acad. Sci. USA – volume: 114 start-page: E3119 year: 2017 end-page: E3128 ident: bib23 article-title: Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice publication-title: Proc. Natl. Acad. Sci. USA – volume: 2020 start-page: 7 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib3 article-title: The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice publication-title: Nature – volume: 2 start-page: 16226 year: 2016 ident: 10.1016/j.cell.2020.06.010_bib8 article-title: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome publication-title: Nat. Microbiol. doi: 10.1038/nmicrobiol.2016.226 – volume: 9 start-page: 357 year: 2012 ident: 10.1016/j.cell.2020.06.010_bib19 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 172 start-page: 1625 year: 2008 ident: 10.1016/j.cell.2020.06.010_bib28 article-title: Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2008.071060 – volume: 7 start-page: 1034 year: 2000 ident: 10.1016/j.cell.2020.06.010_bib2 article-title: A simple method for the rapid generation of recombinant adenovirus vectors publication-title: Gene Ther. doi: 10.1038/sj.gt.3301197 – volume: 166 start-page: 74 year: 1993 ident: 10.1016/j.cell.2020.06.010_bib4 article-title: Growth factors and wound healing: Part II. Role in normal and chronic wound healing publication-title: Am. J. Surg. doi: 10.1016/S0002-9610(05)80589-6 – volume: 3 start-page: 1 year: 2014 ident: 10.1016/j.cell.2020.06.010_bib16 article-title: glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data publication-title: Cell Regen. (Lond.) – volume: 44 start-page: 1379 year: 2016 ident: 10.1016/j.cell.2020.06.010_bib44 article-title: Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses publication-title: Immunity doi: 10.1016/j.immuni.2016.05.006 – volume: 579 start-page: 270 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib45 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature doi: 10.1038/s41586-020-2012-7 – volume: 114 start-page: E3119 year: 2017 ident: 10.1016/j.cell.2020.06.010_bib23 article-title: Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1619109114 – volume: 10 start-page: 135 year: 2004 ident: 10.1016/j.cell.2020.06.010_bib27 article-title: Genetic, cellular and immune approaches to disease therapy: past and future publication-title: Nat. Med. doi: 10.1038/nm990 – volume: 368 start-page: 1016 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib33 article-title: Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 publication-title: Science doi: 10.1126/science.abb7015 – volume: 111 start-page: 4970 year: 2014 ident: 10.1016/j.cell.2020.06.010_bib43 article-title: Rapid generation of a mouse model for Middle East respiratory syndrome publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1323279111 – volume: 182 start-page: 744 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib14 article-title: A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies publication-title: Cell doi: 10.1016/j.cell.2020.06.011 – volume: 3 start-page: e5 year: 2007 ident: 10.1016/j.cell.2020.06.010_bib32 article-title: A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.0030005 – volume: 3 start-page: 93 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib40 article-title: Age-related rhesus macaque models of COVID-19 publication-title: Animal Model Exp Med doi: 10.1002/ame2.12108 – volume: 50 start-page: 907 year: 2019 ident: 10.1016/j.cell.2020.06.010_bib20 article-title: Shared and Distinct Functions of Type I and Type III Interferons publication-title: Immunity doi: 10.1016/j.immuni.2019.03.025 – volume: 79 start-page: 14614 year: 2005 ident: 10.1016/j.cell.2020.06.010_bib17 article-title: ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia publication-title: J. Virol. doi: 10.1128/JVI.79.23.14614-14621.2005 – volume: 40 start-page: 193 year: 1989 ident: 10.1016/j.cell.2020.06.010_bib34 article-title: Role of growth factors in inflammation and repair publication-title: J. Cell. Biochem. doi: 10.1002/jcb.240400208 – volume: 112 start-page: 8738 year: 2015 ident: 10.1016/j.cell.2020.06.010_bib29 article-title: Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1510830112 – volume: 6 start-page: e1000849 year: 2010 ident: 10.1016/j.cell.2020.06.010_bib12 article-title: SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1000849 – volume: 1 start-page: 213 year: 1988 ident: 10.1016/j.cell.2020.06.010_bib11 article-title: Platelet-derived growth factor: a multifunctional regulator of normal and abnormal cell growth publication-title: Biofactors – volume: 27 start-page: 704 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib18 article-title: Infection and Rapid Transmission of SARS-CoV-2 in Ferrets publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.03.023 – volume: 395 start-page: 497 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib15 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 98 start-page: 844 year: 2018 ident: 10.1016/j.cell.2020.06.010_bib26 article-title: Principles and approaches for reproducible scoring of tissue stains in research publication-title: Lab. Invest. doi: 10.1038/s41374-018-0057-0 – volume: 16 start-page: 284 year: 2012 ident: 10.1016/j.cell.2020.06.010_bib39 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS doi: 10.1089/omi.2011.0118 – volume: 83 start-page: 5451 year: 2009 ident: 10.1016/j.cell.2020.06.010_bib38 article-title: Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2 publication-title: J. Virol. doi: 10.1128/JVI.02272-08 – year: 2020 ident: 10.1016/j.cell.2020.06.010_bib13 article-title: Compassionate Use of Remdesivir for Patients with Severe Covid-19 publication-title: New Engl J Med. doi: 10.1056/NEJMoa2007016 – volume: 217 start-page: e20200653 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib30 article-title: COVID-19 and emerging viral infections: The case for interferon lambda publication-title: J. Exp. Med. doi: 10.1084/jem.20200653 – start-page: ciaa325 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib6 article-title: Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility publication-title: Clin Infect Dis. doi: 10.1093/cid/ciaa325 – volume: 57 start-page: 450 year: 2007 ident: 10.1016/j.cell.2020.06.010_bib36 article-title: Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection publication-title: Comp. Med. – volume: 213 start-page: 712 year: 2016 ident: 10.1016/j.cell.2020.06.010_bib22 article-title: Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiv499 – volume: 30 start-page: 269 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib35 article-title: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro publication-title: Cell Res. doi: 10.1038/s41422-020-0282-0 – volume: 8 start-page: 42 year: 1994 ident: 10.1016/j.cell.2020.06.010_bib9 article-title: Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis publication-title: Nat. Genet. doi: 10.1038/ng0994-42 – volume: 81 start-page: 813 year: 2007 ident: 10.1016/j.cell.2020.06.010_bib25 article-title: Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus publication-title: J. Virol. doi: 10.1128/JVI.02012-06 – volume: 15 start-page: 550 year: 2014 ident: 10.1016/j.cell.2020.06.010_bib24 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 12 start-page: 480 year: 2011 ident: 10.1016/j.cell.2020.06.010_bib31 article-title: GC-content normalization for RNA-Seq data publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-480 – volume: 84 start-page: 9318 year: 2010 ident: 10.1016/j.cell.2020.06.010_bib41 article-title: T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice publication-title: J. Virol. doi: 10.1128/JVI.01049-10 – volume: 12 start-page: 323 year: 2011 ident: 10.1016/j.cell.2020.06.010_bib21 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-323 – volume: 3 start-page: e525 year: 2006 ident: 10.1016/j.cell.2020.06.010_bib10 article-title: Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030525 – volume: 130 start-page: 2620 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib7 article-title: Clinical and immunological features of severe and moderate coronavirus disease 2019 publication-title: J. Clin. Invest. doi: 10.1172/JCI137244 – volume: 89 start-page: 3659 year: 2015 ident: 10.1016/j.cell.2020.06.010_bib1 article-title: Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease publication-title: J. Virol. doi: 10.1128/JVI.03427-14 – start-page: eabc1560 year: 2020 ident: 10.1016/j.cell.2020.06.010_bib37 article-title: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir publication-title: Science – year: 2020 ident: 10.1016/j.cell.2020.06.010_bib5 article-title: STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters publication-title: bioRxiv |
| SSID | ssj0008555 |
| Score | 2.69971 |
| Snippet | COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 734 |
| SubjectTerms | Adenoviridae Angiotensin-Converting Enzyme 2 animal models Animals Betacoronavirus - immunology Chlorocebus aethiops Coronavirus Infections - pathology Coronavirus Infections - prevention & control Coronavirus Infections - virology COVID-19 COVID-19 infection Disease Models, Animal Drug Evaluation, Preclinical - methods Female Humans Interferon-gamma - genetics Interferon-gamma - metabolism interferons Lung - pathology Lung - virology lungs Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout mouse model Pandemics - prevention & control pathogenesis Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism pneumonia Pneumonia, Viral - pathology Pneumonia, Viral - prevention & control Pneumonia, Viral - virology polyinosinic-polycytidylic acid rapid methods Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - metabolism SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 signal transduction Specific Pathogen-Free Organisms STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism T-lymphocytes therapeutics transactivators Transduction, Genetic Vaccination vaccine vaccines Vero Cells Viral Load virulence Virus Replication viruses weight loss |
| Title | Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment |
| URI | https://dx.doi.org/10.1016/j.cell.2020.06.010 https://www.ncbi.nlm.nih.gov/pubmed/32643603 https://www.proquest.com/docview/2422009200 https://www.proquest.com/docview/2477616079 https://pubmed.ncbi.nlm.nih.gov/PMC7284240 |
| Volume | 182 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhEOil9JG220dQILfGxLIkSz62m4Sk0KSHbFh6EZIstS6LN3R3D_n3nbHspZuUPdQ3WSOQRqPRN2IehBxJqeuQ-5gxafNMCJVnjkeWMc-cFy7Ch4HCX6_Ki4n4MpXTHTIeYmHQrbLX_Umnd9q6_3PSc_PkrmkwxrcqdAmmHcqpYBjwy4Xugvimn9faWEuZqhhUcPKBug-cST5e-DgONmKRdzk8MYr235fTY_D50Ifyr0vp_Bl52qNJ-ilN-DnZCe0LspfqS96_JN9TUmnkPZ1HaikY3bae3dPJIsTVjGIhtBkF2ErH17eXpxmr6DdAhPMfqACbxTG9td436b3wmNq2pjeDX_o-mZyf3Ywvsr6YQualLpZZ4ULuFNeW48uF1AyAmAd4KKpQx8hBoAA7WsuDklh5Wjofa-uK0kVdgk1T8Vdkt5234Q2hPDoXwZALGouIF8wGLa1UwlmngLwaETZw0fg-0zgWvJiZwaXsl0HOG-S8Qb86lo_Ix_WYu5RnYyu1HDbHbEiLgYtg67jDYScNHCPstm2YrxYGkEqXfyrfSqOAdWWuYIWv0-6v5wooWHDg24ioDblYE2Aa782etvnZpfNWgBAAV739zzW9I0-w1Tkllu_J7vL3KnwAoLR0B91J-ANjERCD |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFLemIQSXiW8KA4wEJxYtTuLYOXCAjallH3Bop4qLsR17BFXpRFuh_l37B3kvTioKqAek5Rjbkv179vPvWe-DkFecy9LF1keM6zjKMhFHJvUsYpYZmxkPHwYKn57l_VH2cczHW-Sqi4VBt8pW9wed3mjr9s9-i-b-ZVVhjG-RyBxMO9ynGZOtZ-WxW_4Eu232dnAIQn6dJEcfhgf9qC0tEFkuk3mUGBcbkUqdoh3PJQNaYoEsZYUrvU8BXmBSWqdOcKzDzI31pTZJbrzMgeFjBibQ-zeAfQjUBoPx-5X6l5yHsgkFqBqYXhupE5zK8DUejNIkbpKGYtjuv2_Dv9nun06bv92CR3fITktf6buA0F2y5ep75GYoaLm8T76ELNYobDr1VFOw8nU5WdLRzPnFhGLltQkFnkwPPp0PDiNW0M9AQacXqHGr2R4919ZW4YFyj-q6pMPOEf4BGV0LxA_Jdj2t3WNCU2-MB8vRSaxanjDtJNdcZEYbAd2LHmEdisq2qc2xwsZEdT5s3xUirxB5hY58LO6RN6sxlyGxx8bevBOOWtueCm6ejeNedpJUcG6xWdduupgpoEZNwqt4Yx8B0OWxgBU-CtJfzRVod5YCbj0i1vbFqgPmDV9vqatvTf5wAZQEiNyT_1zTC3KrPzw9USeDs-On5Da2NB6R-S7Znv9YuGfA0ubmeXMqKPl63cfwFz0nTSE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Generation+of+a+Broadly+Useful+Model+for+COVID-19+Pathogenesis%2C+Vaccination%2C+and+Treatment&rft.jtitle=Cell&rft.au=Sun%2C+Jing&rft.au=Zhuang%2C+Zhen&rft.au=Zheng%2C+Jian&rft.au=Li%2C+Kun&rft.date=2020-08-06&rft.pub=Elsevier+Inc&rft.issn=0092-8674&rft.eissn=1097-4172&rft.volume=182&rft.issue=3&rft.spage=734&rft.epage=743.e5&rft_id=info:doi/10.1016%2Fj.cell.2020.06.010&rft_id=info%3Apmid%2F32643603&rft.externalDocID=PMC7284240 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0092-8674&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0092-8674&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0092-8674&client=summon |