LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma[S]

• Published in: Journal of lipid research Vol. 51; no. 8; pp. 2445 - 2453
• Main Authors: Shoji, Naoki, Nakagawa, Kiyotaka, Asai, Akira, Fujita, Ikuko, Hashiura, Aya, Nakajima, Yasushi, Oikawa, Shinichi, Miyazawa, Teruo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2010; American Society for Biochemistry and Molecular Biology; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: advanced glycation end products; Blood Chemical Analysis - methods; Case-Control Studies; Chromatography, Liquid - methods; diabetes; Diabetes Mellitus - blood; Diabetes Mellitus - metabolism; Erythrocytes - chemistry; Female; Glycation End Products, Advanced - blood; Glycation End Products, Advanced - metabolism; Humans; Hyperglycemia - blood; Hyperglycemia - metabolism; lipid glycation; Male; Methods; Middle Aged; Phosphatidylethanolamines - blood; Phosphatidylethanolamines - metabolism; tandem mass spectrometry; Tandem Mass Spectrometry - methods; Young Adult; tandem mass spectrometry; advanced glycation end products; diabetes; lipid glycation

An amino group of phosphatidylethanolamine (PE) is considered as a target for nonenzymatic glycation, and the potential involvement of lipid glycation in the pathogenesis of diabetic complications has generated interest. However, unlike an early glycation product of PE (Amadori-PE), the occurrence a...