Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial

• Published in: Intensive care medicine Vol. 44; no. 11; pp. 1787 - 1796
• Main Authors: François, Bruno, Mercier, Emmanuelle, Gonzalez, Céline, Asehnoune, Karim, Nseir, Saad, Fiancette, Maud, Desachy, Arnaud, Plantefève, Gaëtan, Meziani, Ferhat, de Lame, Paul-André, Laterre, Pierre-François
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2018; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Anesthesiology; Antibiotics; Antibodies, Monoclonal - therapeutic use; Bacterial pneumonia; Critical Care; Critical Care Medicine; Culture; Double-Blind Method; Drug resistance; Emergency Medicine; Eradication; Feasibility studies; Female; Health aspects; Health services; Hospital patients; Hospitals; Human health and pathology; Humans; Imipenem; Immunoglobulin G; Immunoglobulin G - immunology; Immunologic Factors - therapeutic use; Intensive; Intensive care; Life Sciences; Male; Mechanical ventilation; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Methicillin; Middle Aged; Monoclonal antibodies; Original; Pain Medicine; Patients; Pediatrics; Pharmacokinetics; Pharmacology; Placebos; Pneumology/Respiratory System; Pneumonia; Pneumonia, Staphylococcal - drug therapy; Pneumonia, Ventilator-Associated - drug therapy; Randomization; Respiration, Artificial; Safety; Staphylococcus aureus; Staphylococcus aureus infections; Subgroups; Ventilation; α-Toxin; Belgium; France; Arkansas; HAP/VAP; Adjunctive therapy; Monoclonal antibody; Staphylococcus aureus

Purpose Hospital-acquired bacterial pneumonia (HABP) is a critical concern in hospitals with ventilator-associated bacterial pneumonia (VABP) remaining the most common infection in the ICU, often due to Staphylococcus aureus , an increasingly difficult to treat pathogen. Anti-infective monoclonal an...