Tryptophan hydroxylase gene 1 ( TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers

• Published in: Psychiatry research Vol. 180; no. 2; pp. 63 - 67
• Main Authors: Andreou, Dimitrios, Saetre, Peter, Werge, Thomas, Andreassen, Ole A., Agartz, Ingrid, Sedvall, Göran C., Hall, Håkan, Terenius, Lars, Jönsson, Erik G.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 30.12.2010; Elsevier
• Subjects: 3-merhoxy-4-hydroxyphenylglycol (MHPG); 3-methoxy-4-hydroxyphenylglycol (MHPG); 5-hydroxyindoleacetic acid (5-HIAA); Adolescent; Adult; Biological and medical sciences; Cerebrospinal fluid (CSF); Female; Gene Frequency; Genetics; Genome-Wide Association Study; Homovanillic acid (HVA); Homovanillic Acid - cerebrospinal fluid; Humans; Indoles - cerebrospinal fluid; Male; Medical sciences; MEDICIN; MEDICINE; Miscellaneous; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Polymorphism, Genetic - genetics; Psychiatry; Psykiatri; Tryptophan Hydroxylase - genetics; Young Adult; Genetics; Homovanillic acid (HVA); Cerebrospinal fluid (CSF); 5-hydroxyindoleacetic acid (5-HIAA); 3-methoxy-4-hydroxyphenylglycol (MHPG); Human; Dopamine; Healthy subject; Serotonin; Enzyme; Metabolite; Genetic variant; Central nervous system; Cerebrospinal fluid; Catecholamine; Genetic determinism; Encephalon; Tryptophan 5-monooxygenase; Neurotransmitter; Norepinephrine; Oxidoreductases; Acetic acid; Polymorphism

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. We investigated possible relationships between five TPH1 gene polymorphisms and cerebrospinal fluid (CSF) concentrations of the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the major dopamine metaboli...