Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 156; no. 2; pp. 338 - 354
• Main Authors: Hu, Jianming, Lin, You-Yu, Chen, Pei-Jer, Watashi, Koichi, Wakita, Takaji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Animals; Cell Culture Techniques; Cell Line; Disease Models, Animal; Drug Development; Hepatitis B - etiology; Hepatitis B - therapy; Hepatitis B virus - physiology; Humans; Immune Response; Models, Immunological; Mouse; Treatment; Viral Infection; cccDNA; DMSO; Immune Response; HBeAg; HBsAg; HCC; siRNA; AdV; GLuc; rcDNA; Treatment; alb-uPA; PEG; Mouse; pgRNA; NC; NTCP; HCV; iHep; HDV; HBV; PCR; Viral Infection

Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and limitations of systems for studying HBV and develop...