Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension

• Published in: Schizophrenia research Vol. 198; pp. 6 - 15
• Main Authors: Swerdlow, Neal R., Light, Gregory A., Thomas, Michael L., Sprock, Joyce, Calkins, Monica E., Green, Michael F., Greenwood, Tiffany A., Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura C., Nuechterlein, Keith H., Radant, Allen D., Seidman, Larry J., Siever, Larry J., Silverman, Jeremy M., Stone, William S., Sugar, Catherine A., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., Braff, David L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2018
• Subjects: Acoustic Stimulation; Adolescent; Adult; Analysis of Variance; Antipsychotic Agents - therapeutic use; Cohort Studies; Endophenotype; Endophenotypes; Female; Gait Disorders, Neurologic - epidemiology; Gait Disorders, Neurologic - etiology; Humans; Male; Middle Aged; Neural Inhibition - drug effects; Neural Inhibition - physiology; Prepulse inhibition; Prepulse Inhibition - drug effects; Prepulse Inhibition - physiology; Psychiatric Status Rating Scales; Replication; Schizophrenia; Schizophrenia - complications; Schizophrenia - drug therapy; Schizophrenia - epidemiology; Startle; Young Adult; Schizophrenia; Startle; Replication; Endophenotype; Prepulse inhibition

The Consortium on the Genetics of Schizophrenia (COGS) collected case-control endophenotype and genetic information from 2457 patients and healthy subjects (HS) across 5 test sites over 3.5 years. Analysis of the first “wave” (W1) of 1400 subjects identified prepulse inhibition (PPI) deficits in pat...