Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

• Published in: Human immunology Vol. 83; no. 2; pp. 119 - 129
• Main Authors: Xiang, Haitao, Zhao, Yingze, Li, Xinyang, Liu, Peipei, Wang, Longlong, Wang, Meiniang, Tian, Lei, Sun, Hai-Xi, Zhang, Wei, Xu, Ziqian, Ye, Beiwei, Yuan, Xiaoju, Wang, Pengyan, Zhang, Ning, Gong, Yuhuan, Bian, Chengrong, Wang, Zhaohai, Yu, Linxiang, Yan, Jin, Meng, Fanping, Bai, Changqing, Wang, Xiaoshan, Liu, Xiaopan, Gao, Kai, Wu, Liang, Liu, Longqi, Gu, Ying, Bi, Yuhai, Shi, Yi, Zhang, Shaogeng, Zhu, Chen, Xu, Xun, Wu, Guizhen, Gao, George F., Yang, Naibo, Liu, William J., Yang, Penghui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022; Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics
• Subjects: Adolescent; Adult; Aged, 80 and over; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; B-cell receptor repertoire; B-Lymphocytes - immunology; Clonal expansion; COVID-19; COVID-19 - immunology; Female; Humans; Immunoglobulin Heavy Chains - immunology; Male; Middle Aged; Receptors, Antigen, B-Cell - immunology; SARS-CoV-2; SARS-CoV-2 - immunology; COVID-19; BCR; SARS-CoV-2; SHM; IGH; B-cell receptor repertoire; PBMC; CDR3; Clonal expansion

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of coronavirus disease 2019 (COVID-19). Great international efforts have been put into the development of prophylactic vaccines and neutralizing antibodies. However, the knowledge about the B cell immune response in...