Adenosine monophosphate‐activated protein kinase is elevated in human cachectic muscle and prevents cancer‐induced metabolic dysfunction in mice

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 14; no. 4; pp. 1631 - 1647
• Main Authors: Raun, Steffen H., Ali, Mona S., Han, Xiuqing, Henríquez‐Olguín, Carlos, Pham, T.C. Phung, Meneses‐Valdés, Roberto, Knudsen, Jonas R., Willemsen, Anna C.H., Larsen, Steen, Jensen, Thomas E., Langen, Ramon, Sylow, Lykke
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2023; John Wiley and Sons Inc; Wiley
• Subjects: Adenosine; AMP‐activated protein kinase (AMPK); Bone surgery; cancer cachexia; Glucose; glucose metabolism; Insulin resistance; Kinases; Lung cancer; Medical research; Metabolism; Musculoskeletal system; Original; Patients; Phosphates; Protein expression; Proteins; skeletal muscle; Tumor necrosis factor-TNF; Variance analysis; Denmark; United States > US; skeletal muscle; glucose metabolism; insulin resistance; AMP-activated protein kinase (AMPK); cancer cachexia

Background Metabolic dysfunction and cachexia are associated with poor cancer prognosis. With no pharmacological treatments, it is crucial to define the molecular mechanisms causing cancer‐induced metabolic dysfunction and cachexia. Adenosine monophosphate‐activated protein kinase (AMPK) connects me...