Mathematical model of the relationship between pH holding time and erosive esophagitis healing rates

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 14; no. 1; pp. 28 - 41
• Main Authors: Howden, Colin W., Scarpignato, Carmelo, Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Yuan, Yuhong, Hunt, Richard
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2025; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Cytochrome; Drug dosages; Esophagitis - drug therapy; Esophagus; Gastric Acid - metabolism; Gastroesophageal reflux; Growth factors; Histamine H2 Antagonists - administration & dosage; Histamine H2 Antagonists - pharmacology; Histamine H2 Antagonists - therapeutic use; Humans; Hydrogen-Ion Concentration; Models, Theoretical; Pharmacodynamics; Potassium; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - pharmacology; Proton Pump Inhibitors - therapeutic use; Time Factors

Effective suppression of gastric acid secretion promotes healing of erosive esophagitis. Treatment guidelines recommend proton pump inhibitors (PPIs) and histamine H2–receptor antagonists (H2RAs). Emerging evidence also supports potassium‐competitive acid blockers (P‐CABs). The aim was to construct...