Physiologically based mechanistic insight into differential risk of valproate hepatotoxicity between children and adults: A focus on ontogeny impact - Huang, Yu‐Ting; Huang, Yen‐Ming; Kung, Fan‐Lu; Lin, Chun‐Jung; Jao, Tun; Ho, Yunn‐Fang (CPT: pharmacometrics and systems pharmacology, 2023)
Keywords: Adult; Adults; Age; Anticonvulsants - therapeutic use; Chemical and Drug Induced Liver Injury - etiology; Child; Convulsions & seizures; Cytochrome; Cytochrome P-450 CYP2C9; Drug dosages; Drug-Related Side Effects and Adverse Reactions; Enzymes; Epilepsy; Humans; Infant; Infant, Newborn; Metabolism; Metabolites; Oxidation; Pediatrics; Pharmacokinetics; Plasma; Software; Valproic Acid - adverse effects; Valproic Acid - pharmacokinetics; United States--US; Italy