Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 12; no. 3; pp. 387 - 400
• Main Authors: Hanafin, Patrick O., Abdul Rahim, Nusaibah, Sharma, Rajnikant, Cess, Colin G., Finley, Stacey D., Bergen, Phillip J., Velkov, Tony, Li, Jian, Rao, Gauri G.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2023; John Wiley and Sons Inc; Wiley
• Subjects: Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria; Bacterial infections; Chloramphenicol - metabolism; Chloramphenicol - pharmacology; Drug dosages; Gram-negative bacteria; Humans; Infections; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - metabolism; Lipids; Microbial Sensitivity Tests; Mortality; Multiomics; Pathogens; Pharmacodynamics; Physiology; Polymyxin B - pharmacology

Carbapenemase‐resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic mechanisms that can be used to design and optimize combination...