Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming
Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immun...
Saved in:
Published in | EMBO molecular medicine Vol. 13; no. 8; pp. e14323 - n/a |
---|---|
Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frankfurt
John Wiley & Sons, Inc
09.08.2021
EMBO Press John Wiley and Sons Inc Springer Nature |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4+, CD8+, and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required.
SYNOPSIS
Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation.
KD augmented human CD4+ and CD8+ T cell cytokine production and cell lysis capacity in vitro and in vivo.
Additionally, KD also enhanced regulatory T cell abundance and function, and primed human T cells to memory cell formation.
In response to KD, increased mitochondrial mass, ETC complex formation, aerobic oxidative phosphorylation capacity and ‐tightly controlled‐ ROS production was identified in human T cells.
Transcriptomic analysis revealed fundamental immunometabolic reprogramming of human CD4+ and CD8+ T cells after 3 weeks of KD.
Both, elevated bioenergetic capacity and ROS ‐serving as T‐cell second messenger molecules‐ provide the immunometabolic basis for enhanced T cell immunity on a KD.
Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation. |
---|---|
AbstractList | Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4+, CD8+, and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required.
SYNOPSIS
Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation.
KD augmented human CD4+ and CD8+ T cell cytokine production and cell lysis capacity in vitro and in vivo.
Additionally, KD also enhanced regulatory T cell abundance and function, and primed human T cells to memory cell formation.
In response to KD, increased mitochondrial mass, ETC complex formation, aerobic oxidative phosphorylation capacity and ‐tightly controlled‐ ROS production was identified in human T cells.
Transcriptomic analysis revealed fundamental immunometabolic reprogramming of human CD4+ and CD8+ T cells after 3 weeks of KD.
Both, elevated bioenergetic capacity and ROS ‐serving as T‐cell second messenger molecules‐ provide the immunometabolic basis for enhanced T cell immunity on a KD.
Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation. Very-low-carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno-nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T-cell responses. CD4[sup.+], CD8[sup.+], and regulatory T-cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very-low-carbohydrate diet as a clinical tool to improve human T-cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. Abstract Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4+, CD8+, and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4+, CD8+, and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4 + , CD8 + , and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. Ketogenic diet (KD) is characterized by a very limited uptake of carbohydrates, resulting in endogenous production of ketone bodies. This study identifies KD as a potent nutritional immunometabolic intervention to reprogram human T cell immunometabolism, favouring mitochondrial oxidative phosphorylation, thus enhancing both effector and regulatory T cell immune capacity and priming human T cells towards memory cell formation. |
Audience | Academic |
Author | Marstaller, Xaver Exner, Nicole Heß, Julia Hübner, Max Kreth, Friedrich W Mascolo, Hannah Unger, Kristian Hirschberger, Simon Müller, Martin B Kreth, Simone Ferstl, Alicia Wu, Tingting Strauß, Gabriele Effinger, David Rahmel, Tim |
AuthorAffiliation | 1 Walter Brendel Center of Experimental Medicine Ludwig‐Maximilian‐University München (LMU) Munich Germany 4 Metabolic Biochemistry Biomedical Center (BMC) Faculty of Medicine Ludwig‐Maximilian‐University München (LMU) Munich Germany 3 Department of Anesthesia Intensive Care Medicine and Pain Therapy University Hospital Knappschaftskrankenhaus Bochum Bochum Germany 6 Department of Radiation Oncology LMU University Hospital Ludwig‐Maximilian‐University München (LMU) Munich Germany 5 Helmholtz Center Munich Research Unit Radiation Cytogenetics Neuherberg Germany 2 Department of Anaesthesiology and Intensive Care Medicine Research Unit Molecular Medicine LMU University Hospital Ludwig‐Maximilian‐University München (LMU) Munich Germany |
AuthorAffiliation_xml | – name: 1 Walter Brendel Center of Experimental Medicine Ludwig‐Maximilian‐University München (LMU) Munich Germany – name: 3 Department of Anesthesia Intensive Care Medicine and Pain Therapy University Hospital Knappschaftskrankenhaus Bochum Bochum Germany – name: 5 Helmholtz Center Munich Research Unit Radiation Cytogenetics Neuherberg Germany – name: 6 Department of Radiation Oncology LMU University Hospital Ludwig‐Maximilian‐University München (LMU) Munich Germany – name: 2 Department of Anaesthesiology and Intensive Care Medicine Research Unit Molecular Medicine LMU University Hospital Ludwig‐Maximilian‐University München (LMU) Munich Germany – name: 4 Metabolic Biochemistry Biomedical Center (BMC) Faculty of Medicine Ludwig‐Maximilian‐University München (LMU) Munich Germany |
Author_xml | – sequence: 1 givenname: Simon orcidid: 0000-0002-4221-7377 surname: Hirschberger fullname: Hirschberger, Simon organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 2 givenname: Gabriele surname: Strauß fullname: Strauß, Gabriele organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 3 givenname: David surname: Effinger fullname: Effinger, David organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 4 givenname: Xaver surname: Marstaller fullname: Marstaller, Xaver organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 5 givenname: Alicia orcidid: 0000-0002-8349-0978 surname: Ferstl fullname: Ferstl, Alicia organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 6 givenname: Martin B surname: Müller fullname: Müller, Martin B organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 7 givenname: Tingting surname: Wu fullname: Wu, Tingting organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 8 givenname: Max surname: Hübner fullname: Hübner, Max organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 9 givenname: Tim surname: Rahmel fullname: Rahmel, Tim organization: University Hospital Knappschaftskrankenhaus Bochum – sequence: 10 givenname: Hannah surname: Mascolo fullname: Mascolo, Hannah organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 11 givenname: Nicole surname: Exner fullname: Exner, Nicole organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 12 givenname: Julia surname: Heß fullname: Heß, Julia organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 13 givenname: Friedrich W surname: Kreth fullname: Kreth, Friedrich W organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 14 givenname: Kristian surname: Unger fullname: Unger, Kristian organization: Ludwig‐Maximilian‐University München (LMU) – sequence: 15 givenname: Simone orcidid: 0000-0002-0073-2098 surname: Kreth fullname: Kreth, Simone email: simone.kreth@med.uni-muenchen.de organization: Ludwig‐Maximilian‐University München (LMU) |
BookMark | eNqFks1q3DAUhU1JaX7adbeGbrqZiX4s2eqiEELaBjJ0k3YrruVrW4MlpbKdMLs-Qp-xT1JNJkyYUigCSVyd84l7uKfZkQ8es-wtJUsqmGDn6JxbMsIoLTjjL7ITWopyUciqONrfS3mcnY7jmhApJK1eZce8oIIKzk4y_I5x8_vnryE8pN1ArEO_aSJMmDcWpxx9D97gmPezA5_fbkU4DLl1bvZ22uRTH8Pc9btCcDhBHQZr8oh3MXQRnLO-e529bGEY8c3TeZZ9-3R1e_llcfP18_Xlxc3CiIrxBedFqSSnLbZNzUteFIoxrJRojJICEJisOZICKWkogbplTEklWlqzUtRE8bPsesdtAqz1XbQO4kYHsPqxEGKnIU7WDKhT92BIxSk3pFCGQCnrFKksGgCloE2sjzvW3Vw7bAz6KcJwAD188bbXXbjXFRekUiQB3j8BYvgx4zhpZ8dteOAxzKNmouAlEUTQJH33l3Qd5uhTVEklFK84UeJZ1UFqwPo2pH_NFqovSkqErKjaZrD8hyqtBp01aXxam-oHhvOdwcQwjhHbfY-U6Mcp09sp0_spS44PO8dDQm3-J9dXq9Xq2fwHQ2PZgg |
CitedBy_id | crossref_primary_10_1038_s42255_022_00646_1 crossref_primary_10_1016_j_immuni_2023_07_002 crossref_primary_10_1158_0008_5472_CAN_23_2742 crossref_primary_10_1016_j_diabres_2021_108983 crossref_primary_10_1111_jnc_15959 crossref_primary_10_1186_s40779_022_00437_5 crossref_primary_10_1016_j_intimp_2023_110622 crossref_primary_10_1002_eji_202350521 crossref_primary_10_1016_j_clnu_2022_05_007 crossref_primary_10_3390_immuno3010001 crossref_primary_10_3390_v15061262 crossref_primary_10_3389_fnut_2022_878382 crossref_primary_10_1161_CIRCRESAHA_123_321872 crossref_primary_10_1002_trc2_12423 crossref_primary_10_3389_fmed_2022_923502 crossref_primary_10_1038_s41392_022_01104_w crossref_primary_10_1038_s41392_024_01771_x crossref_primary_10_1084_jem_20221839 crossref_primary_10_1210_endocr_bqac124 crossref_primary_10_1210_endocr_bqac067 crossref_primary_10_3390_vaccines10020242 crossref_primary_10_3389_fonc_2022_979154 crossref_primary_10_1016_j_coi_2024_102422 crossref_primary_10_1038_s41556_022_01002_x crossref_primary_10_1002_ece3_10315 crossref_primary_10_1515_hsz_2021_0281 crossref_primary_10_3389_fimmu_2022_1003006 crossref_primary_10_3389_fonc_2022_878675 crossref_primary_10_1002_ijc_34668 crossref_primary_10_1016_j_smim_2023_101736 crossref_primary_10_1016_j_trecan_2023_06_003 crossref_primary_10_3390_cancers15102862 crossref_primary_10_1016_j_isci_2023_107839 crossref_primary_10_1007_s00101_023_01258_4 crossref_primary_10_1016_j_clnu_2023_04_027 crossref_primary_10_2174_0109298673275492231121062033 crossref_primary_10_3389_fimmu_2022_805881 crossref_primary_10_1016_j_ebiom_2024_105156 crossref_primary_10_1038_s41586_022_05128_8 crossref_primary_10_1007_s11428_022_00924_2 crossref_primary_10_1177_11206721221074201 crossref_primary_10_3389_fimmu_2023_1118448 crossref_primary_10_3389_fimmu_2023_1133308 |
Cites_doi | 10.1152/ajpregu.00240.2018 10.1038/s41598-018-20933-w 10.1007/s00204-015-1520-y 10.1016/S0140-6736(18)31812-9 10.1136/bmjopen-2020-038532 10.1038/s41598-019-51782-w 10.1172/JCI200319246 10.1016/j.eplepsyres.2011.09.021 10.3390/ijms21165793 10.1073/pnas.2015486117 10.1073/pnas.1413965111 10.1016/j.isci.2020.101761 10.1016/j.celrep.2020.01.022 10.3390/nu11050962 10.1084/jem.20010659 10.1016/j.mito.2017.10.006 10.1016/j.cmet.2014.05.004 10.3390/md13020996 10.1038/s41556-019-0440-0 10.1016/S2468-2667(18)30135-X 10.1038/ni.3659 10.1152/physrev.00026.2013 10.3389/fnut.2018.00105 10.1038/s41418-019-0410-x 10.1038/ijo.2017.131 10.1016/j.immuni.2013.02.005 10.3389/fendo.2018.00783 10.1016/j.immuni.2012.10.020 10.1073/pnas.1814273116 10.1016/j.cmet.2017.08.004 10.1038/nm.3893 10.1093/bioinformatics/bts635 10.4049/jimmunol.1003613 10.1186/s12986-017-0178-2 10.1126/science.aay4014 10.1016/j.cell.2013.05.016 10.1016/j.immuni.2007.05.023 10.1073/pnas.1721049115 10.1093/eurheartj/ehy736 10.1016/0065-2571(66)90027-6 10.3390/nu12020306 10.1073/pnas.1221740110 10.1126/science.7678183 10.1186/1756-0500-4-427 10.1016/j.cmet.2013.05.008 10.1038/ni1096 10.1016/j.cmet.2016.12.022 10.1186/s10020-018-0056-z 10.1056/NEJMsr043743 10.1016/j.celrep.2012.10.009 10.1073/pnas.0506580102 10.1016/j.nut.2015.02.007 10.1038/nm.3624 10.1016/j.neuint.2010.10.017 10.1001/jama.2016.3829 10.1038/s41416-019-0651-y 10.1126/scisignal.2000976 10.1016/j.semcancer.2017.06.007 10.1016/j.cell.2016.05.035 10.1111/j.1600-065X.2012.01155.x 10.1038/s41577-020-0402-6 10.1016/j.cell.2017.12.013 10.1016/j.it.2018.01.005 10.1172/jci.insight.145207 10.1001/jama.2018.11025 10.1016/j.immuni.2011.09.021 10.1001/jamanetworkopen.2019.15360 10.1038/nm.3804 10.1016/j.immuni.2011.12.007 10.1186/s13059-014-0550-8 10.1001/jama.282.22.2131 10.1016/j.immuni.2017.08.009 10.1016/j.immuni.2014.06.005 10.1016/j.celrep.2017.02.004 10.1093/bioinformatics/btu638 10.1038/ejcn.2013.116 10.1038/s41577-019-0156-1 10.1152/ajpheart.00646.2012 |
ContentType | Journal Article |
Copyright | 2021 The Authors. Published under the terms of the CC BY 4.0 license COPYRIGHT 2021 John Wiley & Sons, Inc. 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2021 The Authors. Published under the terms of the CC BY 4.0 license – notice: COPYRIGHT 2021 John Wiley & Sons, Inc. – notice: 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 24P WIN AAYXX CITATION 3V. 7X7 7XB 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M7P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
DOI | 10.15252/emmm.202114323 |
DatabaseName | Wiley-Blackwell Open Access Collection Wiley Free Archive CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central ProQuest Natural Science Collection ProQuest One Community College Coronavirus Research Database ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley-Blackwell Open Access Collection url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Biology |
DocumentTitleAlternate | Simon Hirschberger et al |
EISSN | 1757-4684 |
EndPage | n/a |
ExternalDocumentID | oai_doaj_org_article_532ac08313c049c0a76b15264daa99af A710568199 10_15252_emmm_202114323 EMMM202114323 |
Genre | article |
GrantInformation_xml | – fundername: Ludwig‐Maximilians‐University (LMU) Munich |
GroupedDBID | --- 0R~ 1OC 24P 4.4 53G 5DZ 5GY 5VS 7X7 8-0 8-1 8AO 8FE 8FH 8FI 8FJ AAHHS AAZKR ABJNI ABOCM ABUWG ACCFJ ACGFO ACGFS ACPRK ACXQS ADBBV ADKYN ADPDF ADZMN ADZOD AEEZP AEGXH AENEX AEQDE AFBPY AFKRA AHMBA AIAGR AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BTFSW BVXVI CCPQU D-9 DIK DU5 EBD EBS EMOBN F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HK~ HMCUK HYE HZ~ IAO IHR KQ8 LH4 LK8 M48 M7P M~E NNB O9- OIG OK1 OVD OVEED P2P PIMPY PQQKQ PROAC RHF RHI RNS ROL RPM SV3 TEORI UKHRP WIN XV2 AAYXX CITATION ITC AEUQT 3V. 7XB 8FK AZQEC COVID DWQXO GNUQQ K9. PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c5823-33479631fefdb37344922e895dc965aea26b3e04e10d10abf229695f1b275b093 |
IEDL.DBID | RPM |
ISSN | 1757-4676 |
IngestDate | Tue Oct 22 15:09:15 EDT 2024 Tue Sep 17 21:19:33 EDT 2024 Fri Jun 28 12:34:29 EDT 2024 Thu Oct 10 22:05:49 EDT 2024 Fri Feb 23 00:00:36 EST 2024 Wed Jan 10 04:24:46 EST 2024 Thu Sep 26 15:40:56 EDT 2024 Sat Aug 24 01:02:53 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
License | Attribution This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c5823-33479631fefdb37344922e895dc965aea26b3e04e10d10abf229695f1b275b093 |
Notes | These authors contributed equally to this work ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-0073-2098 0000-0002-8349-0978 0000-0002-4221-7377 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350890/ |
PMID | 34151532 |
PQID | 2559383095 |
PQPubID | 866378 |
PageCount | 18 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_532ac08313c049c0a76b15264daa99af pubmedcentral_primary_oai_pubmedcentral_nih_gov_8350890 proquest_miscellaneous_2543705051 proquest_journals_2559383095 gale_infotracmisc_A710568199 gale_infotracacademiconefile_A710568199 crossref_primary_10_15252_emmm_202114323 wiley_primary_10_15252_emmm_202114323_EMMM202114323 |
PublicationCentury | 2000 |
PublicationDate | 09 August 2021 |
PublicationDateYYYYMMDD | 2021-08-09 |
PublicationDate_xml | – month: 08 year: 2021 text: 09 August 2021 day: 09 |
PublicationDecade | 2020 |
PublicationPlace | Frankfurt |
PublicationPlace_xml | – name: Frankfurt – name: Hoboken |
PublicationTitle | EMBO molecular medicine |
PublicationYear | 2021 |
Publisher | John Wiley & Sons, Inc EMBO Press John Wiley and Sons Inc Springer Nature |
Publisher_xml | – name: John Wiley & Sons, Inc – name: EMBO Press – name: John Wiley and Sons Inc – name: Springer Nature |
References | 2013; 29 2018; 320 2017; 41 2017; 8 2020; 20 2017; 47 2019; 11 2002; 195 2013; 67 2015; 31 2020; 17 2020; 369 2019; 19 2004; 5 2018; 41 2020; 122 2020; 12 2011; 59 2020; 10 2003; 114 2012; 249 2003; 112 2014; 20 2015; 89 2018; 9 2018; 8 2018; 39 2018; 3 2018; 5 2013; 17 2018; 172 2020; 1 2005; 102 2014; 15 2019; 116 2016; 315 2013; 110 2013; 153 2010; 3 1993; 259 2014; 94 2007; 27 1966; 4 2015; 13 2021; 6 2019; 9 2012; 100 2017; 26 2005; 352 2017; 25 2019; 2 2013; 304 2016; 166 2011; 35 2011; 4 2014; 41 2012; 36 2014; 111 2018; 24 2012; 2 2019; 40 2018; 392 2013; 38 2018; 315 2017; 14 2020; 30 1999; 282 2018; 115 2015; 21 2020; 27 2017; 18 2020; 23 2020; 22 2020; 21 2011; 186 e_1_2_11_70_1 e_1_2_11_72_1 e_1_2_11_32_1 e_1_2_11_55_1 e_1_2_11_78_1 e_1_2_11_30_1 e_1_2_11_57_1 e_1_2_11_36_1 e_1_2_11_51_1 e_1_2_11_74_1 e_1_2_11_13_1 e_1_2_11_34_1 e_1_2_11_53_1 e_1_2_11_76_1 e_1_2_11_11_1 e_1_2_11_29_1 e_1_2_11_6_1 e_1_2_11_27_1 e_1_2_11_4_1 e_1_2_11_48_1 e_1_2_11_2_1 e_1_2_11_60_1 e_1_2_11_81_1 e_1_2_11_20_1 e_1_2_11_45_1 e_1_2_11_66_1 e_1_2_11_47_1 e_1_2_11_68_1 e_1_2_11_24_1 e_1_2_11_41_1 e_1_2_11_62_1 e_1_2_11_22_1 e_1_2_11_43_1 e_1_2_11_64_1 e_1_2_11_17_1 e_1_2_11_15_1 e_1_2_11_59_1 e_1_2_11_38_1 e_1_2_11_19_1 e_1_2_11_50_1 e_1_2_11_10_1 e_1_2_11_31_1 e_1_2_11_56_1 e_1_2_11_77_1 e_1_2_11_58_1 e_1_2_11_79_1 e_1_2_11_14_1 e_1_2_11_35_1 e_1_2_11_52_1 e_1_2_11_12_1 Stubbs BJ (e_1_2_11_71_1) 2020; 1 e_1_2_11_33_1 e_1_2_11_54_1 e_1_2_11_75_1 e_1_2_11_7_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_26_1 e_1_2_11_3_1 e_1_2_11_49_1 Cahill GF (e_1_2_11_8_1) 2003; 114 Torre‐Minguela C (e_1_2_11_73_1) 2017; 8 e_1_2_11_82_1 e_1_2_11_61_1 e_1_2_11_80_1 e_1_2_11_21_1 e_1_2_11_44_1 e_1_2_11_67_1 e_1_2_11_46_1 e_1_2_11_69_1 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_63_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_42_1 e_1_2_11_65_1 e_1_2_11_18_1 e_1_2_11_16_1 e_1_2_11_37_1 e_1_2_11_39_1 |
References_xml | – volume: 116 start-page: 3688 year: 2019 end-page: 3694 article-title: Western diet regulates immune status and the response to LPS‐driven sepsis independent of diet‐associated microbiome publication-title: Proc Natl Acad Sci USA – volume: 172 start-page: 162 year: 2018 end-page: 175 article-title: Western diet triggers NLRP3‐dependent innate immune reprogramming publication-title: Cell – volume: 320 start-page: 969 year: 2018 end-page: 970 article-title: The challenge of reforming nutritional epidemiologic research publication-title: JAMA – volume: 21 start-page: 677 year: 2015 end-page: 687 article-title: Inflammasomes: mechanism of action, role in disease, and therapeutics publication-title: Nat Med – volume: 112 start-page: 1796 year: 2003 end-page: 1808 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J Clin Invest – volume: 11 start-page: 962 year: 2019 article-title: Low‐carb and ketogenic diets in type 1 and type 2 diabetes publication-title: Nutrients – volume: 369 start-page: eaay4014 year: 2020 article-title: The science and medicine of human immunology publication-title: Science – volume: 38 start-page: 201 year: 2013 end-page: 202 article-title: Mitochondrial ROS fire up T cell activation publication-title: Immunity – volume: 31 start-page: 166 year: 2015 end-page: 169 article-title: HTSeq–a Python framework to work with high‐throughput sequencing data publication-title: Bioinformatics – volume: 20 start-page: 61 year: 2014 end-page: 72 article-title: The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function publication-title: Cell Metab – volume: 3 start-page: e419 year: 2018 end-page: e428 article-title: Dietary carbohydrate intake and mortality: a prospective cohort study and meta‐analysis publication-title: Lancet Public Health – volume: 29 start-page: 15 year: 2013 end-page: 21 article-title: STAR: ultrafast universal RNA‐seq aligner publication-title: Bioinformatics – volume: 9 year: 2019 article-title: Identification of suitable controls for miRNA quantification in T‐cells and whole blood cells in sepsis publication-title: Sci Rep – volume: 12 year: 2020 article-title: Safety and effectiveness of the prolonged treatment of children with a ketogenic diet publication-title: Nutrients – volume: 47 start-page: 406 year: 2017 end-page: 420 article-title: Foundations of Immunometabolism and Implications for Metabolic Health and Disease publication-title: Immunity – volume: 2 year: 2019 article-title: Discrepancies in the registries of diet vs drug trials publication-title: JAMA Netw Open – volume: 40 start-page: 394 year: 2019 article-title: Is the PURE study pure fiction? publication-title: Eur Heart J – volume: 41 start-page: 1324 year: 2017 end-page: 1330 article-title: Increased risk of influenza among vaccinated adults who are obese publication-title: Int J Obesity – volume: 5 start-page: 818 year: 2004 end-page: 827 article-title: T cells express a phagocyte‐type NADPH oxidase that is activated after T cell receptor stimulation publication-title: Nat Immunol – volume: 19 start-page: 267 year: 2019 end-page: 268 article-title: The western lifestyle has lasting effects on metaflammation publication-title: Nat Rev Immunol – volume: 4 start-page: 427 year: 2011 article-title: Selection of reliable reference genes for quantitative real‐time PCR in human T cells and neutrophils publication-title: BMC Res Notes – volume: 195 start-page: 59 year: 2002 end-page: 70 article-title: Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen‐activated protein kinase activation and fas ligand expression publication-title: J Exp Med – volume: 89 start-page: 1209 year: 2015 end-page: 1226 article-title: Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism publication-title: Arch Toxicol – volume: 31 start-page: 727 year: 2015 end-page: 732 article-title: Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity publication-title: Nutrition – volume: 30 start-page: 1898 year: 2020 end-page: 1909 article-title: Mitochondrial oxidative phosphorylation regulates the fate decision between pathogenic Th17 and regulatory T cells publication-title: Cell Rep – volume: 114 start-page: 149 year: 2003 end-page: 161 article-title: Ketoacids? Good medicine? publication-title: Trans Am Clin Climatol Assoc – volume: 25 start-page: 262 year: 2017 end-page: 284 article-title: Multi‐dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics publication-title: Cell Metab – volume: 2 start-page: 1300 year: 2012 end-page: 1315 article-title: T cell activation is driven by an ADP‐dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation publication-title: Cell Rep – volume: 5 start-page: 105 year: 2018 article-title: The Failure to Measure Dietary Intake Engendered a Fictional Discourse on Diet‐Disease Relations publication-title: Front Nutr – volume: 18 start-page: 2077 year: 2017 end-page: 2087 article-title: β‐hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares publication-title: Cell Rep – volume: 249 start-page: 14 year: 2012 end-page: 26 article-title: Metabolic reprogramming and metabolic dependency in T cells publication-title: Immunol Rev – volume: 94 start-page: 909 year: 2014 end-page: 950 article-title: Mitochondrial reactive oxygen species (ROS) and ROS‐induced ROS release publication-title: Physiol Rev – volume: 304 start-page: H1060 year: 2013 end-page: H1076 article-title: Ketone body metabolism and cardiovascular disease publication-title: Am J Physiol Heart Circ Physiol – volume: 17 start-page: 851 year: 2013 end-page: 859 article-title: Immunological goings‐on in visceral adipose tissue publication-title: Cell Metab – volume: 23 year: 2020 article-title: On the origin of ATP synthesis in cancer publication-title: iScience – volume: 102 start-page: 15545 year: 2005 end-page: 15550 article-title: Gene set enrichment analysis: a knowledge‐based approach for interpreting genome‐wide expression profiles publication-title: Proc Natl Acad Sci USA – volume: 110 start-page: 14336 year: 2013 end-page: 14341 article-title: CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability publication-title: Proc Natl Acad Sci USA – volume: 35 start-page: 871 year: 2011 end-page: 882 article-title: The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation publication-title: Immunity – volume: 67 start-page: 789 year: 2013 end-page: 796 article-title: Beyond weight loss: a review of the therapeutic uses of very‐low‐carbohydrate (ketogenic) diets publication-title: Eur J Clin Nutr – volume: 392 start-page: 2288 year: 2018 end-page: 2297 article-title: Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study publication-title: Lancet – volume: 315 start-page: R1210 year: 2018 end-page: R1219 article-title: The effect of a short‐term low‐carbohydrate, high‐fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 10 year: 2020 article-title: Impact of carbohydrate‐reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial publication-title: BMJ Open – volume: 8 year: 2018 article-title: Effects of the ketogenic diet in overweight divers breathing enriched air nitrox publication-title: Sci Rep – volume: 115 start-page: E8017 year: 2018 end-page: E8026 article-title: Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity publication-title: Proc Natl Acad Sci USA – volume: 1 start-page: 43 year: 2020 end-page: 65 article-title: Investigating ketone bodies as immunometabolic countermeasures against respiratory viral infections publication-title: Med (N Y) – volume: 27 start-page: 1214 year: 2020 end-page: 1224 article-title: T‐cell receptor signal strength and epigenetic control of Bim predict memory CD8 T‐cell fate publication-title: Cell Death Differ – volume: 8 start-page: 43 year: 2017 article-title: The NLRP3 and pyrin inflammasomes: implications in the pathophysiology of autoinflammatory diseases publication-title: Front Immunol – volume: 21 start-page: 263 year: 2015 end-page: 269 article-title: The ketone metabolite β‐hydroxybutyrate blocks NLRP3 inflammasome‐mediated inflammatory disease publication-title: Nat Med – volume: 282 start-page: 2131 year: 1999 end-page: 2135 article-title: Elevated C‐reactive protein levels in overweight and obese adults publication-title: JAMA – volume: 20 start-page: 709 year: 2014 end-page: 711 article-title: Unraveling the truth about antioxidants: mitohormesis explains ROS‐induced health benefits publication-title: Nat Med – volume: 18 start-page: 283 year: 2017 end-page: 292 article-title: Postprandial macrophage‐derived IL‐1β stimulates insulin, and both synergistically promote glucose disposal and inflammation publication-title: Nat Immunol – volume: 6 start-page: e145207 year: 2021 article-title: Ketogenic diet and ketone bodies enhance the anticancer effects of PD‐1 blockade publication-title: JCI Insight – volume: 14 start-page: 19 year: 2017 article-title: Press‐pulse: a novel therapeutic strategy for the metabolic management of cancer publication-title: Nutr Metab – volume: 3 start-page: ra59 year: 2010 article-title: The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling publication-title: Sci Signal – volume: 59 start-page: 445 year: 2011 end-page: 455 article-title: The structure and allosteric regulation of glutamate dehydrogenase publication-title: Neurochem Int – volume: 39 start-page: 489 year: 2018 end-page: 502 article-title: Reactive oxygen species: involvement in T cell signaling and metabolism publication-title: Trends Immunol – volume: 47 start-page: 29 year: 2017 end-page: 42 article-title: The mitochondrial dynamics in cancer and immune‐surveillance publication-title: Semin Cancer Biol – volume: 153 start-page: 1239 year: 2013 end-page: 1251 article-title: Posttranscriptional control of T cell effector function by aerobic glycolysis publication-title: Cell – volume: 41 start-page: 75 year: 2014 end-page: 88 article-title: Memory CD8 T cells use cell‐intrinsic lipolysis to support the metabolic programming necessary for development publication-title: Immunity – volume: 17 start-page: 24384 year: 2020 end-page: 24391 article-title: Suboptimal SARS‐CoV‐2−specific CD8 T cell response associated with the prominent HLA‐A*02:01 phenotype publication-title: Proc Natl Acad Sci USA – volume: 166 start-page: 63 year: 2016 end-page: 76 article-title: Mitochondrial dynamics controls T cell fate through metabolic programming publication-title: Cell – volume: 259 start-page: 87 year: 1993 end-page: 91 article-title: Adipose expression of tumor necrosis factor‐alpha: direct role in obesity‐linked insulin resistance publication-title: Science – volume: 24 start-page: 54 year: 2018 article-title: MicroRNAs 143 and 150 in whole blood enable detection of T‐cell immunoparalysis in sepsis publication-title: Mol Med – volume: 4 start-page: 339 year: 1966 end-page: 354 article-title: The regulation of the release of ketone bodies by the liver publication-title: Adv Enzyme Regul – volume: 21 start-page: 5793 year: 2020 article-title: Obesity and COVID‐19: molecular mechanisms linking both pandemics publication-title: Int J Mol Sci – volume: 111 start-page: 16647 year: 2014 end-page: 16653 article-title: Meal frequency and timing in health and disease publication-title: Proc Natl Acad Sci USA – volume: 41 start-page: 51 year: 2018 end-page: 57 article-title: Mitochondrial activity in T cells publication-title: Mitochondrion – volume: 352 start-page: 1138 year: 2005 end-page: 1145 article-title: A potential decline in life expectancy in the United States in the 21st century publication-title: N Engl J Med – volume: 186 start-page: 3299 year: 2011 end-page: 3303 article-title: Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets publication-title: J Immunol – volume: 100 start-page: 295 year: 2012 end-page: 303 article-title: Modulation of oxidative stress and mitochondrial function by the ketogenic diet publication-title: Epilepsy Res – volume: 9 start-page: 783 year: 2018 article-title: The roles of mitochondrial SIRT4 in cellular metabolism publication-title: Front Endocrinol – volume: 122 start-page: 168 year: 2020 end-page: 181 article-title: Oncogenic pathways and the electron transport chain: a dangeROS liaison publication-title: Br J Cancer – volume: 36 start-page: 68 year: 2012 end-page: 78 article-title: Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development publication-title: Immunity – volume: 27 start-page: 268 year: 2007 end-page: 280 article-title: The proapoptotic factors Bax and Bak regulate T cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis publication-title: Immunity – volume: 13 start-page: 996 year: 2015 end-page: 1009 article-title: Effects of n‐3 polyunsaturated fatty acids (ω‐3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet publication-title: Mar Drugs – volume: 15 start-page: 550 year: 2014 article-title: Moderated estimation of fold change and dispersion for RNA‐seq data with DESeq2 publication-title: Genome Biol – volume: 26 start-page: 547 year: 2017 end-page: 557 article-title: Ketogenic diet reduces midlife mortality and improves memory in aging mice publication-title: Cell Metab – volume: 38 start-page: 225 year: 2013 end-page: 236 article-title: Mitochondria are required for antigen‐specific T cell activation through reactive oxygen species signaling publication-title: Immunity – volume: 315 start-page: 2269 year: 2016 article-title: Lifespan weighed down by diet publication-title: JAMA – volume: 22 start-page: 18 year: 2020 end-page: 25 article-title: Ketogenesis‐generated β‐hydroxybutyrate is an epigenetic regulator of CD8 T‐cell memory development publication-title: Nat Cell Biol – volume: 20 start-page: 529 year: 2020 end-page: 536 article-title: T cell responses in patients with COVID‐19 publication-title: Nat Rev Immunol – ident: e_1_2_11_50_1 doi: 10.1152/ajpregu.00240.2018 – ident: e_1_2_11_6_1 doi: 10.1038/s41598-018-20933-w – ident: e_1_2_11_38_1 doi: 10.1007/s00204-015-1520-y – ident: e_1_2_11_15_1 doi: 10.1016/S0140-6736(18)31812-9 – ident: e_1_2_11_60_1 doi: 10.1136/bmjopen-2020-038532 – ident: e_1_2_11_25_1 doi: 10.1038/s41598-019-51782-w – ident: e_1_2_11_78_1 doi: 10.1172/JCI200319246 – ident: e_1_2_11_46_1 doi: 10.1016/j.eplepsyres.2011.09.021 – ident: e_1_2_11_63_1 doi: 10.3390/ijms21165793 – ident: e_1_2_11_24_1 doi: 10.1073/pnas.2015486117 – ident: e_1_2_11_44_1 doi: 10.1073/pnas.1413965111 – ident: e_1_2_11_67_1 doi: 10.1016/j.isci.2020.101761 – ident: e_1_2_11_69_1 doi: 10.1016/j.celrep.2020.01.022 – ident: e_1_2_11_5_1 doi: 10.3390/nu11050962 – volume: 8 start-page: 43 year: 2017 ident: e_1_2_11_73_1 article-title: The NLRP3 and pyrin inflammasomes: implications in the pathophysiology of autoinflammatory diseases publication-title: Front Immunol contributor: fullname: Torre‐Minguela C – ident: e_1_2_11_17_1 doi: 10.1084/jem.20010659 – ident: e_1_2_11_16_1 doi: 10.1016/j.mito.2017.10.006 – ident: e_1_2_11_42_1 doi: 10.1016/j.cmet.2014.05.004 – ident: e_1_2_11_56_1 doi: 10.3390/md13020996 – ident: e_1_2_11_81_1 doi: 10.1038/s41556-019-0440-0 – ident: e_1_2_11_65_1 doi: 10.1016/S2468-2667(18)30135-X – ident: e_1_2_11_19_1 doi: 10.1038/ni.3659 – ident: e_1_2_11_82_1 doi: 10.1152/physrev.00026.2013 – ident: e_1_2_11_3_1 doi: 10.3389/fnut.2018.00105 – ident: e_1_2_11_35_1 doi: 10.1038/s41418-019-0410-x – ident: e_1_2_11_52_1 doi: 10.1038/ijo.2017.131 – ident: e_1_2_11_49_1 doi: 10.1016/j.immuni.2013.02.005 – ident: e_1_2_11_47_1 doi: 10.3389/fendo.2018.00783 – ident: e_1_2_11_66_1 doi: 10.1016/j.immuni.2012.10.020 – volume: 1 start-page: 43 year: 2020 ident: e_1_2_11_71_1 article-title: Investigating ketone bodies as immunometabolic countermeasures against respiratory viral infections publication-title: Med (N Y) contributor: fullname: Stubbs BJ – ident: e_1_2_11_51_1 doi: 10.1073/pnas.1814273116 – ident: e_1_2_11_53_1 doi: 10.1016/j.cmet.2017.08.004 – ident: e_1_2_11_23_1 doi: 10.1038/nm.3893 – ident: e_1_2_11_18_1 doi: 10.1093/bioinformatics/bts635 – ident: e_1_2_11_45_1 doi: 10.4049/jimmunol.1003613 – ident: e_1_2_11_68_1 doi: 10.1186/s12986-017-0178-2 – ident: e_1_2_11_59_1 doi: 10.1126/science.aay4014 – ident: e_1_2_11_9_1 doi: 10.1016/j.cell.2013.05.016 – ident: e_1_2_11_30_1 doi: 10.1016/j.immuni.2007.05.023 – ident: e_1_2_11_37_1 doi: 10.1073/pnas.1721049115 – ident: e_1_2_11_4_1 doi: 10.1093/eurheartj/ehy736 – ident: e_1_2_11_32_1 doi: 10.1016/0065-2571(66)90027-6 – ident: e_1_2_11_64_1 doi: 10.3390/nu12020306 – ident: e_1_2_11_74_1 doi: 10.1073/pnas.1221740110 – ident: e_1_2_11_27_1 doi: 10.1126/science.7678183 – ident: e_1_2_11_34_1 doi: 10.1186/1756-0500-4-427 – ident: e_1_2_11_43_1 doi: 10.1016/j.cmet.2013.05.008 – ident: e_1_2_11_29_1 doi: 10.1038/ni1096 – ident: e_1_2_11_58_1 doi: 10.1016/j.cmet.2016.12.022 – ident: e_1_2_11_48_1 doi: 10.1186/s10020-018-0056-z – ident: e_1_2_11_54_1 doi: 10.1056/NEJMsr043743 – ident: e_1_2_11_31_1 doi: 10.1016/j.celrep.2012.10.009 – ident: e_1_2_11_72_1 doi: 10.1073/pnas.0506580102 – ident: e_1_2_11_13_1 doi: 10.1016/j.nut.2015.02.007 – ident: e_1_2_11_62_1 doi: 10.1038/nm.3624 – ident: e_1_2_11_36_1 doi: 10.1016/j.neuint.2010.10.017 – ident: e_1_2_11_40_1 doi: 10.1001/jama.2016.3829 – ident: e_1_2_11_61_1 doi: 10.1038/s41416-019-0651-y – ident: e_1_2_11_33_1 doi: 10.1126/scisignal.2000976 – ident: e_1_2_11_70_1 doi: 10.1016/j.semcancer.2017.06.007 – ident: e_1_2_11_7_1 doi: 10.1016/j.cell.2016.05.035 – ident: e_1_2_11_77_1 doi: 10.1111/j.1600-065X.2012.01155.x – volume: 114 start-page: 149 year: 2003 ident: e_1_2_11_8_1 article-title: Ketoacids? Good medicine? publication-title: Trans Am Clin Climatol Assoc contributor: fullname: Cahill GF – ident: e_1_2_11_10_1 doi: 10.1038/s41577-020-0402-6 – ident: e_1_2_11_11_1 doi: 10.1016/j.cell.2017.12.013 – ident: e_1_2_11_21_1 doi: 10.1016/j.it.2018.01.005 – ident: e_1_2_11_20_1 doi: 10.1172/jci.insight.145207 – ident: e_1_2_11_28_1 doi: 10.1001/jama.2018.11025 – ident: e_1_2_11_76_1 doi: 10.1016/j.immuni.2011.09.021 – ident: e_1_2_11_41_1 doi: 10.1001/jamanetworkopen.2019.15360 – ident: e_1_2_11_80_1 doi: 10.1038/nm.3804 – ident: e_1_2_11_79_1 doi: 10.1016/j.immuni.2011.12.007 – ident: e_1_2_11_39_1 doi: 10.1186/s13059-014-0550-8 – ident: e_1_2_11_75_1 doi: 10.1001/jama.282.22.2131 – ident: e_1_2_11_26_1 doi: 10.1016/j.immuni.2017.08.009 – ident: e_1_2_11_55_1 doi: 10.1016/j.immuni.2014.06.005 – ident: e_1_2_11_22_1 doi: 10.1016/j.celrep.2017.02.004 – ident: e_1_2_11_2_1 doi: 10.1093/bioinformatics/btu638 – ident: e_1_2_11_57_1 doi: 10.1038/ejcn.2013.116 – ident: e_1_2_11_12_1 doi: 10.1038/s41577-019-0156-1 – ident: e_1_2_11_14_1 doi: 10.1152/ajpheart.00646.2012 |
SSID | ssj0065618 |
Score | 2.5334542 |
Snippet | Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that... Very-low-carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that... Abstract Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions... |
SourceID | doaj pubmedcentral proquest gale crossref wiley |
SourceType | Open Website Open Access Repository Aggregation Database Publisher |
StartPage | e14323 |
SubjectTerms | Analysis Carbohydrates CD4 antigen CD8 antigen Cytokines Diet Energy resources Immunity Immunity (Disease) immunometabolism Inflammation ketogenic diet Ketones Low carbohydrate diet Lymphocytes Lymphocytes T Memory (Computers) metabolic therapy Metabolism Mitochondria Nutrient deficiency Nutrition research nutritional intervention Oxidative metabolism Phosphorylation Physiological aspects Protein expression Proteins Reactive oxygen species Respiration RNA sequencing T cells T‐cell immunity |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NatwwEBYl0NJLadOWuk2LC4X2YiLrz9YxLQmhsD0lJTchyWN2YdcbNg5lb32EPmOfpDOyd4nJIZdeDLZ-kGdGmk_26BvGPsmaQ11DW4TGywIROBR1W4ZCSR6j9Q20MbF9_jDnl-r7lb66k-qLYsIGeuBBcMdaCh8pHZaMCGYj95UJ6HOMary31rdp9S31bjM1rMEIUtKXPfSNVYFLgRlJfbTQ4hhWKzqCjq2UFHLijxJt__3F-X7A5F0gmzzR2XP2bISQ-ckw9BfsEXSH7PGQVHJ7yJ7Mxt_lLxn8hM327-8_y_UvvEa_Cev5tiFyiLxZQJ9DNyel3-QpU19-QZVgucwX6dBIv83HLD7Dg_UKejSZ5SLmRIWZ4rpW6Plescuz04tv58WYV6GIuhaykHR61MiyhbYJspJKWSGgtrqJ1mgPXpgggSsoeVNyH1ohrLEaVSgqHbiVr9lBt-7gDctLAa3h0VRQS9V6EcAEFQ325X3wYDP2ZSdddz3QZzjadpAiHCnC7RWRsa8k_X014r1OD9Aa3GgN7iFryNhn0p2j2Ymain48ZICjJZ4rd4KAiijXLI7saFITZ1WcFu-078ZZfeNo-4U7ekSlGfu4L6aWFKnWwfqW6ihZUXrAMmPVxGombzYt6RbzxOyNcJjXlmdMJvt6SGTudDab7e_e_g8BvmNPqcMU4miP2EG_uYX3CLv68CHNsH8mUisk priority: 102 providerName: Directory of Open Access Journals – databaseName: Coronavirus Research Database dbid: COVID link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELZgKxAXfgqIQEFBQoJL2sROnPiESmlVkBYubdWbZTuT7ordpOxmhZYTj8Az8iR4HGchVAKJS6SNJ5G983k844y_IeQFK2IoCqgiXSoWWQ8coqJKdJSy2BihSqiMY_v8wI9P0_fn2bnfcFv6tMreJjpDXTYG98j30PW10ZT1CF5ffo6wahR-XfUlNK6TLVbYSGdEtg4-nr1729ti66y4HT67RuaRNQnck_tkNKN7MJ_jUXQbAaWMssG65Oj7rxrpq4mTvzu0bkU6ukNkP5YuEeXT7qrVu-brHzSP_z_Yu-S2d1bD_Q5d98g1qLfJja585Xqb3Bz7D_P3CZzBYv3j2_dZ88VejVroZrIukYYiLKfQhlBPEF7L0NUEDE9QCGazcOqOp7Tr0NcL6m40c2gtOGdTEyLppssgm9s19gE5PTo8OTiOfAWHyGQFZRHDc6qcJRVUpWY5S1NBKRQiK43gmQJFuWYQp5DEZRIrXVEquMgsWGie6Viwh2RUNzU8ImFCoeKx4TkULK0U1cB1arh9l1JagQjIq15_8rIj6pAY4KCqJapablQdkDeo340YMmy7G83iQvoJKzNGlcEybMzYIMrEKufavoynpVJCqCogLxEdEu2AxYJR_jiD7S0yasl967ohuZuwPdsZSNr5a4bNPQaktx9L-QsAAXm-acYnMSeuhmaFMinLsRBhEpB8gMvByIYt9XTiOMSt4x0XIg4Icwj-118mD8fj8ebX4793-Qm5haIuTVLskFG7WMFT67q1-pmfnz8BkQhHdg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals (Open Access) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fa9UwFA46UXwRnYqdUyoI-lJNkzRtHkSmbAyhPu3K3kKSnnov3Ntq1zH735uT21stG-hj84s030lzTpN8HyGveUGhKKBObGV44j1wSIo6tYng1DllKqhdYPv8Kk8X4st5dv5HDmgcwIsbQzvUk1p063e_fg4f_YT_MKr3sPew2eClch_LCM74bXKHCS7Q3EsxbSl4vyUtRm6fGyrNlqXA3n_9G3393OTf_mxYkE4ekgejJxkfbaF_RG5Bs0_ubrUlh31yrxx3zR8T_Q26IVm3V4kznW2XQ4X8EHG1gj6GZom4X8RBrC8-S_BPfrwKt0b6IR5lfLYJ7QZ6bzPrlYuRCzMc7Nr4pe8JWZwcn30-TUZhhcRlBeMJx-ujkqc11JXlORdCMQaFyiqnZGbAMGk5UAEprVJqbM2YkirzGLI8s1Txp2SvaRt4RuKUQS2pkzkUXNSGWZBWOOnbMsYaUBF5uxtX_WPLn6Ex7kAINEKgJwgi8gnHfSqGxNchoe2-63Ee6Ywz41AdjTsf2zhqcml9Y1JUxihl6oi8QdQ0GozHyJnxloHvLRJd6SPvUSHnmvI9O5yV9NPKzbN3uOudVWqMv3xI793SiLyasrEmHlVroL3EMoLnqA-YRiSf2cvszeY5zWoZqL29P0wLRSPCg2X9a8j0cVmW09PBf_TpObmP5cMRRnVI9vruEl54t6q3L8N0-Q2y1SEF priority: 102 providerName: Scholars Portal – databaseName: Wiley-Blackwell Open Access Collection dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Pi9UwEA-6ongRXZXtukoFQS_FNknT5rjKLovwxMOueAtJOvU9eK-V97rIu_kR9jP6SZxJ_2DZg-CltE0a2kwm-U068xvG3ogyhbKEOnGVFQkicEjKOnOJFKn32lZQ-8D2-VldXMlP3_LRm5BiYXp-iGnDjTQjzNek4Nbtxow9xBoKmw2FkqMFIwUXd9k9BDclDWwuv4yTMaKVsMWHi2SR4JygBnYfauL9vIHZwhT4-2_P0rc9J_9GtGFJOn_MHg1YMj7thf-E3YHmkN3vs0vuD9mDxfDf_CmDr7Dd__51s25_4tHbrWuX-4pYIuJqBV0MzZKkv4tDyr74kirBeh2vQvRIt4-HdD79jXYDHY6d9crHxIkZHLw2uAQ-Y1fnZ5cfL5IhwULi85KLRFAYqRJZDXXlRCGk1JxDqfPKa5VbsFw5AamELK2y1Lqac610jrLkRe5SLZ6zg6Zt4IjFGYdapV4VUApZW-5AOekVtmWts6Aj9m7sXfOj59EwZH-QIAwJwkyCiNgH6v2pGhFghxvt9rsZ9MnkgltPWdKERxvHp7ZQDhtTsrJWa1tH7C3JzpCaoqS8HaIN8G2J8MqcIrIi7jWNb3Yyq4nq5efFo_TNoN47Q3YYmvYITyP2eiqmJ8llrYH2mupIUVCewCxixWzUzL5sXtKsloHiG3FxWuo0YiKMr391mTlbLBbT1fF_PfWCPaTz4NyoT9hBt72Glwi4OvcqqNQfohAnEw priority: 102 providerName: Wiley-Blackwell |
Title | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
URI | https://onlinelibrary.wiley.com/doi/abs/10.15252%2Femmm.202114323 https://www.proquest.com/docview/2559383095 https://search.proquest.com/docview/2543705051 https://pubmed.ncbi.nlm.nih.gov/PMC8350890 https://doaj.org/article/532ac08313c049c0a76b15264daa99af |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Rb9MwELa2IRAvCAaIwKiChAQvWRPbceLHrXQaSBkV2qa-WbZzoZWaZOo6ob7xE_iN_BLObloR7QGJF0eJHcfxnX13yd13hLxneQx5DlVkSs0i1MAhyqvERJzF1kpdQmU92ueFOL_iX6bpdI-k21gY77Rvzfy4WdTHzXzmfStvajvc-okNJ8UItYY4l_Fwn-xnjG1N9M32i_qJ_6iHYjGLcBcQHZ5PSlM6hLp20edo9HBGXQod3MNRoDPak0oevP_-Fn3fbfJvddbLo7On5EmnSIYnmwE_I3vQHJKHm9SS60PyqOh-mj8ncA3L9e-fvxbtDyytXpp2ti4dRERYzmEVQjNzpL8Nfb6-8NI1gsUinPvQkdU67HL5bC60NayQcRZzGzpATO_dVaP8e0GuzsaXo_Ooy64Q2TSnLGIuhlSwpIKqNCxjnEtKIZdpaaVINWgqDIOYQxKXSaxNRakUMkVC0iw1sWQvyUHTNvCKhAmFSsRWZJAzXmlqQBhuBfaltdEgA_JxO7vqZgOioZzx4WiiHE3UjiYBOXWzv2vm0K_9hXb5XXU8oJBg2roUacyigWNjnQmDnQleai2lrgLywdFOuTWKlLK6CzXA0Tq0K3WCapUDXpM4sqNeS1xbtl-9pb7q1vatckYY2vWomwbk3a7a3en81Rpo71wbzjKXJDAJSNbjmt6b9WuQ3T2-d8feAWGev_41ZWpcFMXu7PV_P-8Neex68d6N8ogcrJZ38BY1rpUZkH3KJ1hm02xAHpyOLybf8Dj6ev3508B_xcCy4PnAr8Q_j_wyvg |
link.rule.ids | 230,315,733,786,790,870,891,2115,11589,12083,21416,24346,27955,27956,31752,31753,33777,33778,38549,43343,43838,43928,46085,46509,50847,50956,53825,53827,74100,74657,74767 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELZgK34u_BQQgQJBQoJL2sROnPiESmm1hW65tFVvlu1M2BW7SdnNCi0nHoFn5EnweL0LoRJIXCIldiI783lmbI-_IeQFK2IoCqgiXSoWWQ8coqJKdJSy2BihSqiMY_s85v3T9N15du4X3GY-rHKlE52iLhuDa-Q76Pra2ZT1CF5ffI4waxTurvoUGlfJhjWstOiRjb0PZ4dvV7rYOituhc_ayDyyKoF7cp-MZnQHJhM8im5nQCmjrGOXHH3_ZSV9OXDyd4fWWaSD20Su-rIMRPm0PW_1tvn6B83j_3f2DrnlndVwd4muu-QK1Jvk2jJ95WKTXB_4jfl7BM5guvjx7fu4-WKvRk11M1yUSEMRliNoQ6iHCK9Z6HIChidYCcbjcOSOp7SL0OcLWj5oJtBacI5HJkTSTRdBNrE29j45Pdg_2etHPoNDZLKCsojhOVXOkgqqUrOcpamgFAqRlUbwTIGiXDOIU0jiMomVrigVXGQWLDTPdCzYA9KrmxoekjChUPHY8BwKllaKauA6Ndx-SymtQATk1Up-8mJJ1CFxgoOilihquRZ1QN6gfNfVkGHbPWimH6UfsDJjVBlMw8aMnUSZWOVc24_xtFRKCFUF5CWiQ6IesFgwyh9nsK1FRi25a103JHcTtmVbnZp2_Jpu8QoD0uuPmfwFgIA8XxfjmxgTV0MzxzopyzERYRKQvIPLTs-6JfVo6DjEreMdFyIOCHMI_tcvk_uDwWB99-jvTX5GbvRPBkfy6PD4_WNyE19zIZNii_Ta6RyeWDeu1U_9WP0J_rNKXQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgFRUXPgqIQIEgIcEl3cROnPiESj_UAls4tFVvlu1M2FV3k7KbFVpO_AR-I78Ej9e7ECrBhUukxE5kx8_jN8n4DSEvWBFDUUAV6VKxyDJwiIoq0VHKYmOEKqEyTu3zmB-epm_Ps3Mf_zT1YZVLm-gMddkY_EbeQ-prvSnLCHqVD4v4uHfw-vJzhBmk8E-rT6dxnaxbisytI7a---HsaG9ply1xcV_77HqZR9Y8cC_0k9GM9mA8xm3p1htKGWWdNcpJ-V812FeDKH8nt251OrhNLpb9WgSlXGzPWr1tvv4h-fh_On6H3PIkNtxZoO4uuQb1JrmxSGs53yQbff_D_h6BM5jMf3z7Pmq-2KNRE90M5iXKU4TlENoQ6gHCbhq6XIHhCVaC0Sgcum0r7Tz0eYQWF5oxtBa0o6EJUYzTRZaN7dp7n5we7J_sHkY-s0NksoKyiOH-Vc6SCqpSs5ylqaAUCpGVRvBMgaJcM4hTSOIyiZWuKBVcZBZENM90LNgDslY3NTwkYUKh4rHhORQsrRTVwHVquH2WUlqBCMir5VjKy4WAh0THB4dd4rDL1bAH5A2O9aoaKm-7C83kk_QTWWaMKoPp2ZixzpWJVc61fRhPS6WEUFVAXiJSJNoHiwuj_DYH21pU2pI7ltKh6JuwLdvq1LTz2nSLl3iQ3q5M5S8wBOT5qhjvxFi5GpoZ1klZjgkKk4DkHYx2etYtqYcDpy1uCXlciDggzKH5X69M7vf7_dXZo783-RnZsMiV74-O3z0mN_EuF0kptshaO5nBE8vuWv3UT9ufanVTIA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Very-low-carbohydrate+diet+enhances+human+T-cell+immunity+through+immunometabolic+reprogramming&rft.jtitle=EMBO+molecular+medicine&rft.au=Hirschberger%2C+Simon&rft.au=Strau%C3%9F%2C+Gabriele&rft.au=Effinger%2C+David&rft.au=Marstaller%2C+Xaver&rft.date=2021-08-09&rft.eissn=1757-4684&rft.volume=13&rft.issue=8&rft.spage=e14323&rft.epage=e14323&rft_id=info:doi/10.15252%2Femmm.202114323&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1757-4676&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1757-4676&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1757-4676&client=summon |