Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram‐negative bacteria

• Published in: Journal of internal medicine Vol. 264; no. 1; pp. 17 - 29
• Main Authors: Keyser, P., Elofsson, M., Rosell, S., Wolf‐Watz, H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2008; Blackwell Science
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibacterial agents; antibiotic resistance; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Proteins - antagonists & inhibitors; Biological and medical sciences; Chlamydia; Drug Resistance, Bacterial; General aspects; Gram-Negative Bacteria - pathogenicity; Gram-Negative Bacterial Infections - drug therapy; Humans; Medical sciences; Pharmacology. Drug treatments; Salmonidae; type III secretion system; Virulence - drug effects; virulence blockers; Virulence Factors - antagonists & inhibitors; Medicine; Resistance; Antibiotic; virulence blockers; Secretion; antibiotic resistance; Virulence; type III secretion system; Inhibitor; Antibacterial agent; Gram negative bacteria

. In recent years mounting problems related to antibiotic‐resistant bacteria have resulted in the prediction that we are entering the preantibiotic era. A way of preventing such a development would be to introduce novel antibacterial medicines with modes of action distinct from conventional antibiot...