Warm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition

• Published in: European journal of cardio-thoracic surgery Vol. 33; no. 2; pp. 215 - 221
• Main Authors: Kon, Zachary N., Brown, Emile N., Grant, Michael C., Ozeki, Toshinaga, Burris, Nicholas S., Collins, Michael J., Kwon, Michael H., Poston, Robert S.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier Science B.V 01.02.2008
• Subjects: Acidosis - complications; Acidosis - epidemiology; Aged; Aprotinin; Aprotinin - pharmacology; Aprotinin - therapeutic use; Coronary artery bypass; Coronary Artery Bypass, Off-Pump - methods; Female; Graft Occlusion, Vascular - blood; Graft Occlusion, Vascular - etiology; Humans; Hypercoagulabilty; Intraoperative Care - methods; Ischemia; Male; Middle Aged; Myocarditis - etiology; Myoglobin - blood; Myoglobin - drug effects; OPCAB; Platelet Activation - drug effects; Prospective Studies; Serine Proteinase Inhibitors - pharmacology; Serine Proteinase Inhibitors - therapeutic use; Thrombophilia - blood; Thrombophilia - etiology; Thrombophilia - prevention & control; Thrombosis - blood; Tumor Necrosis Factor-alpha - blood; Warm Ischemia - adverse effects; Aprotinin; Coronary artery bypass; Ischemia; OPCAB; Hypercoagulabilty

Objective: Accumulating evidence suggests that a hypercoagulable state influences early graft failure after off-pump coronary artery bypass (OPCAB). We hypothesized that regional myocardial ischemia caused by obligatory periods of coronary occlusion during OPCAB is an important trigger for this prot...