Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model

Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 17; no. 10; p. 1603
Main Authors Zhang, Xi-Feng, Shen, Wei, Gurunathan, Sangiliyandi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.10.2016
MDPI
Subjects
Animals
Cell Survival - drug effects
DNA Damage - drug effects
Endothelial Cells - cytology
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Epithelial Cells - cytology
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Humans
Keratin
Macrophages - cytology
Macrophages - drug effects
Macrophages - metabolism
Metal Nanoparticles - chemistry
Metal Nanoparticles - toxicity
Molecular chemistry
Nanoparticles
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Reactive Oxygen Species - metabolism
Review
Silver
Silver - chemistry
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - metabolism
Toxicity
cellular effect
stem cells
endothelial cells
fibroblasts
silver nanoparticles
epithelial cells
macrophage
neuronal cells
keratinocytes
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms17101603

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Abstract Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently, several studies have reported both beneficial and toxic effects of AgNPs on various prokaryotic and eukaryotic systems. To develop nanoparticles for mediated therapy, several laboratories have used a variety of cell lines under in vitro conditions to evaluate the properties, mode of action, differential responses, and mechanisms of action of AgNPs. In vitro models are simple, cost-effective, rapid, and can be used to easily assess efficacy and performance. The cytotoxicity, genotoxicity, and biocompatibility of AgNPs depend on many factors such as size, shape, surface charge, surface coating, solubility, concentration, surface functionalization, distribution of particles, mode of entry, mode of action, growth media, exposure time, and cell type. Cellular responses to AgNPs are different in each cell type and depend on the physical and chemical nature of AgNPs. This review evaluates significant contributions to the literature on biological applications of AgNPs. It begins with an introduction to AgNPs, with particular attention to their overall impact on cellular effects. The main objective of this review is to elucidate the reasons for different cell types exhibiting differential responses to nanoparticles even when they possess similar size, shape, and other parameters. Firstly, we discuss the cellular effects of AgNPs on a variety of cell lines; Secondly, we discuss the mechanisms of action of AgNPs in various cellular systems, and try to elucidate how AgNPs interact with different mammalian cell lines and produce significant effects; Finally, we discuss the cellular activation of various signaling molecules in response to AgNPs, and conclude with future perspectives on research into AgNPs.
AbstractList Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently, several studies have reported both beneficial and toxic effects of AgNPs on various prokaryotic and eukaryotic systems. To develop nanoparticles for mediated therapy, several laboratories have used a variety of cell lines under in vitro conditions to evaluate the properties, mode of action, differential responses, and mechanisms of action of AgNPs. In vitro models are simple, cost-effective, rapid, and can be used to easily assess efficacy and performance. The cytotoxicity, genotoxicity, and biocompatibility of AgNPs depend on many factors such as size, shape, surface charge, surface coating, solubility, concentration, surface functionalization, distribution of particles, mode of entry, mode of action, growth media, exposure time, and cell type. Cellular responses to AgNPs are different in each cell type and depend on the physical and chemical nature of AgNPs. This review evaluates significant contributions to the literature on biological applications of AgNPs. It begins with an introduction to AgNPs, with particular attention to their overall impact on cellular effects. The main objective of this review is to elucidate the reasons for different cell types exhibiting differential responses to nanoparticles even when they possess similar size, shape, and other parameters. Firstly, we discuss the cellular effects of AgNPs on a variety of cell lines; Secondly, we discuss the mechanisms of action of AgNPs in various cellular systems, and try to elucidate how AgNPs interact with different mammalian cell lines and produce significant effects; Finally, we discuss the cellular activation of various signaling molecules in response to AgNPs, and conclude with future perspectives on research into AgNPs.
Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently, several studies have reported both beneficial and toxic effects of AgNPs on various prokaryotic and eukaryotic systems. To develop nanoparticles for mediated therapy, several laboratories have used a variety of cell lines under in vitro conditions to evaluate the properties, mode of action, differential responses, and mechanisms of action of AgNPs. In vitro models are simple, cost-effective, rapid, and can be used to easily assess efficacy and performance. The cytotoxicity, genotoxicity, and biocompatibility of AgNPs depend on many factors such as size, shape, surface charge, surface coating, solubility, concentration, surface functionalization, distribution of particles, mode of entry, mode of action, growth media, exposure time, and cell type. Cellular responses to AgNPs are different in each cell type and depend on the physical and chemical nature of AgNPs. This review evaluates significant contributions to the literature on biological applications of AgNPs. It begins with an introduction to AgNPs, with particular attention to their overall impact on cellular effects. The main objective of this review is to elucidate the reasons for different cell types exhibiting differential responses to nanoparticles even when they possess similar size, shape, and other parameters. Firstly, we discuss the cellular effects of AgNPs on a variety of cell lines; Secondly, we discuss the mechanisms of action of AgNPs in various cellular systems, and try to elucidate how AgNPs interact with different mammalian cell lines and produce significant effects; Finally, we discuss the cellular activation of various signaling molecules in response to AgNPs, and conclude with future perspectives on research into AgNPs.Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently, several studies have reported both beneficial and toxic effects of AgNPs on various prokaryotic and eukaryotic systems. To develop nanoparticles for mediated therapy, several laboratories have used a variety of cell lines under in vitro conditions to evaluate the properties, mode of action, differential responses, and mechanisms of action of AgNPs. In vitro models are simple, cost-effective, rapid, and can be used to easily assess efficacy and performance. The cytotoxicity, genotoxicity, and biocompatibility of AgNPs depend on many factors such as size, shape, surface charge, surface coating, solubility, concentration, surface functionalization, distribution of particles, mode of entry, mode of action, growth media, exposure time, and cell type. Cellular responses to AgNPs are different in each cell type and depend on the physical and chemical nature of AgNPs. This review evaluates significant contributions to the literature on biological applications of AgNPs. It begins with an introduction to AgNPs, with particular attention to their overall impact on cellular effects. The main objective of this review is to elucidate the reasons for different cell types exhibiting differential responses to nanoparticles even when they possess similar size, shape, and other parameters. Firstly, we discuss the cellular effects of AgNPs on a variety of cell lines; Secondly, we discuss the mechanisms of action of AgNPs in various cellular systems, and try to elucidate how AgNPs interact with different mammalian cell lines and produce significant effects; Finally, we discuss the cellular activation of various signaling molecules in response to AgNPs, and conclude with future perspectives on research into AgNPs.
Author Shen, Wei
Zhang, Xi-Feng
Gurunathan, Sangiliyandi
AuthorAffiliation 3 Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 143-701, Korea
2 Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China; shenwei427@163.com
1 College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China; zhangxf9465@163.com
AuthorAffiliation_xml – name: 2 Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China; shenwei427@163.com
– name: 1 College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China; zhangxf9465@163.com
– name: 3 Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 143-701, Korea
Author_xml – sequence: 1
  givenname: Xi-Feng
  surname: Zhang
  fullname: Zhang, Xi-Feng
– sequence: 2
  givenname: Wei
  surname: Shen
  fullname: Shen, Wei
– sequence: 3
  givenname: Sangiliyandi
  surname: Gurunathan
  fullname: Gurunathan, Sangiliyandi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27669221$$D View this record in MEDLINE/PubMed
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Keywords cellular effect
stem cells
endothelial cells
fibroblasts
silver nanoparticles
epithelial cells
macrophage
neuronal cells
keratinocytes
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Snippet Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles,...
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SubjectTerms Animals
Cell Survival - drug effects
DNA Damage - drug effects
Endothelial Cells - cytology
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Epithelial Cells - cytology
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Humans
Keratin
Macrophages - cytology
Macrophages - drug effects
Macrophages - metabolism
Metal Nanoparticles - chemistry
Metal Nanoparticles - toxicity
Molecular chemistry
Nanoparticles
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Reactive Oxygen Species - metabolism
Review
Silver
Silver - chemistry
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - metabolism
Toxicity
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Title Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
URI https://www.ncbi.nlm.nih.gov/pubmed/27669221
https://www.proquest.com/docview/1831878081
https://www.proquest.com/docview/1824224462
https://www.proquest.com/docview/1850778951
https://pubmed.ncbi.nlm.nih.gov/PMC5085636
Volume 17
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