Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy

• Published in: International journal of cardiology Vol. 168; no. 4; pp. 4039 - 4045
• Main Authors: Longenecker, Chris T, Jiang, Ying, Yun, Chun-Ho, Debanne, Sara, Funderburg, Nicholas T, Lederman, Michael M, Storer, Norma, Labbato, Danielle E, Bezerra, Hiram G, McComsey, Grace A
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 09.10.2013; Elsevier
• Subjects: Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - pathology; Adult; Anti-Retroviral Agents - adverse effects; Anti-Retroviral Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cross-Sectional Studies; Double-Blind Method; Female; Heart; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; Human viral diseases; Humans; Infectious diseases; Inflammation; Inflammation - chemically induced; Inflammation - diagnosis; Inflammation - epidemiology; Macrophages; Male; Medical sciences; Middle Aged; Pericardium - drug effects; Pericardium - pathology; Pharmacology. Drug treatments; Risk Factors; Vascular Calcification - chemically induced; Vascular Calcification - diagnosis; Vascular Calcification - epidemiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Inflammation; Adipose tissue; HIV; Macrophages; Atherosclerosis; Antiretroviral agent; Cardiovascular disease; Vascular disease; Antiviral; Cardiology; Immunopathology; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Chemotherapy; Treatment; Viral disease; Risk factor; Cardiovascular risk; Fat; Human immunodeficiency virus; Macrophage

Abstract Background HIV-infection is characterized by chronic immune activation that persists despite effective antiretroviral therapy (ART) and is associated with elevated cardiovascular risk. Whether specific perivascular fat depots are associated with inflammation in HIV is unknown. Methods In a...