A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer
Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) w...
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| Published in | Gastroenterology (New York, N.Y. 1943) Vol. 140; no. 3; pp. 892 - 902 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2011
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0016-5085 1528-0012 1528-0012 |
| DOI | 10.1053/j.gastro.2010.10.058 |
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| Abstract | Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in
prostate stem cell antigen (
PSCA), but the loci of the other 2 were not investigated.
We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants.
A region of a strong linkage disequilibrium with the 2 SNPs contained
mucin 1 (
MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803:
P = 4.33 × 10
−13; odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 (
P = 1.43 × 10
−11; OR, 1.66 by meta-analysis) in
MUC1 affects promoter activity and determines the major splicing variants of
MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in
PSCA and rs4072037 in
MUC1 have a high risk for developing DGC (OR, 8.38).
MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in
MUC1 might be used to identify individuals at risk for this type of gastric cancer. |
|---|---|
| AbstractList | Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen (PSCA), but the loci of the other 2 were not investigated.
We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants.
A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 (MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10(-13); odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 (P = 1.43 × 10(-11); OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38).
MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer. Background & Aims Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen ( PSCA ), but the loci of the other 2 were not investigated. Methods We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants. Results A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 ( MUC1 ) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10−13 ; odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 ( P = 1.43 × 10−11 ; OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38). Conclusions MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer. Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen ( PSCA), but the loci of the other 2 were not investigated. We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants. A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 ( MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10 −13; odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 ( P = 1.43 × 10 −11; OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38). MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer. Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen (PSCA), but the loci of the other 2 were not investigated.BACKGROUND & AIMSTwo major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic factors, although the mechanism is unknown. Our previous genome-wide association study associated 3 single nucleotide polymorphisms (SNPs) with diffuse-type gastric cancer (DGC); 1 was a functional SNP (rs2294008) in prostate stem cell antigen (PSCA), but the loci of the other 2 were not investigated.We performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants.METHODSWe performed high-density mapping to explore a linkage disequilibrium status of the 2 SNPs at chromosome 1q22. A DGC case-control study was conducted using DNA from 606 cases and 1264 controls (all Japanese individuals) and validated using DNA from Japanese (304 cases, 1465 controls) and Korean (452 cases, 372 controls) individuals. The effects of SNPs on function were analyzed by reporter assays and analyses of splice variants.A region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 (MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10(-13); odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 (P = 1.43 × 10(-11); OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38).RESULTSA region of a strong linkage disequilibrium with the 2 SNPs contained mucin 1 (MUC1) and other 4 genes and SNPs significantly associated with DGC (rs2070803: P = 4.33 × 10(-13); odds ratio [OR], 1.71 by meta-analysis of the studies on the 3 panels) but not with intestinal-type gastric cancer. Functional studies demonstrated that rs4072037 (P = 1.43 × 10(-11); OR, 1.66 by meta-analysis) in MUC1 affects promoter activity and determines the major splicing variants of MUC1 in the gastric epithelium. Individuals that carry both SNPs rs2294008 in PSCA and rs4072037 in MUC1 have a high risk for developing DGC (OR, 8.38).MUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer.CONCLUSIONSMUC1 is the second major DGC susceptibility gene identified. The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer. |
| Author | Nakamura, Tsuneya Yanagihara, Kazuyoshi Kook, Myeong–Cherl Yoon, Kyong–Ah Kato, Shunji Tanioka, Fumihiko Kim, Young–Woo Lee, Yeon–Su Sasaki, Hiroki Saito, Akira Sakamoto, Hiromi Yasui, Wataru Nakamura, Yusuke Kuchiba, Aya Tajima, Kazuo Matsuno, Yoshihiro Shimoda, Tadakazu Park, Sook Ryun Aoyagi, Kazuhiko Hirose, Hiroshi Tanaka, Hideo Sugimura, Haruhiko Katai, Hitoshi Choi, Il Ju Nishina, Tomohiro Totsuka, Hirohiko Hirohashi, Setsuo Saeki, Norihisa Yoshida, Teruhiko Chiku, Suenori Matsuo, Keitaro Ohnami, Sumiko |
| Author_xml | – sequence: 1 givenname: Norihisa surname: Saeki fullname: Saeki, Norihisa organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 2 givenname: Akira surname: Saito fullname: Saito, Akira organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 3 givenname: Il Ju surname: Choi fullname: Choi, Il Ju organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 4 givenname: Keitaro surname: Matsuo fullname: Matsuo, Keitaro organization: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan – sequence: 5 givenname: Sumiko surname: Ohnami fullname: Ohnami, Sumiko organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 6 givenname: Hirohiko surname: Totsuka fullname: Totsuka, Hirohiko organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 7 givenname: Suenori surname: Chiku fullname: Chiku, Suenori organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 8 givenname: Aya surname: Kuchiba fullname: Kuchiba, Aya organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 9 givenname: Yeon–Su surname: Lee fullname: Lee, Yeon–Su organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 10 givenname: Kyong–Ah surname: Yoon fullname: Yoon, Kyong–Ah organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 11 givenname: Myeong–Cherl surname: Kook fullname: Kook, Myeong–Cherl organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 12 givenname: Sook Ryun surname: Park fullname: Park, Sook Ryun organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 13 givenname: Young–Woo surname: Kim fullname: Kim, Young–Woo organization: Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea – sequence: 14 givenname: Hideo surname: Tanaka fullname: Tanaka, Hideo organization: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan – sequence: 15 givenname: Kazuo surname: Tajima fullname: Tajima, Kazuo organization: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan – sequence: 16 givenname: Hiroshi surname: Hirose fullname: Hirose, Hiroshi organization: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan – sequence: 17 givenname: Fumihiko surname: Tanioka fullname: Tanioka, Fumihiko organization: Iwata City Hospital, Shizuoka, Japan – sequence: 18 givenname: Yoshihiro surname: Matsuno fullname: Matsuno, Yoshihiro organization: Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan – sequence: 19 givenname: Haruhiko surname: Sugimura fullname: Sugimura, Haruhiko organization: First Department of Pathology, Hamamatsu University School of Medicine, Shizuoka, Japan – sequence: 20 givenname: Shunji surname: Kato fullname: Kato, Shunji organization: Department of Surgery, Nippon Medical School Hospital, Tokyo, Japan – sequence: 21 givenname: Tsuneya surname: Nakamura fullname: Nakamura, Tsuneya organization: Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan – sequence: 22 givenname: Tomohiro surname: Nishina fullname: Nishina, Tomohiro organization: Department of Internal Medicine, Shikoku Cancer Center, Ehime, Japan – sequence: 23 givenname: Wataru surname: Yasui fullname: Yasui, Wataru organization: Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan – sequence: 24 givenname: Kazuhiko surname: Aoyagi fullname: Aoyagi, Kazuhiko organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 25 givenname: Hiroki surname: Sasaki fullname: Sasaki, Hiroki organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 26 givenname: Kazuyoshi surname: Yanagihara fullname: Yanagihara, Kazuyoshi organization: Department of Life Sciences, Yasuda Women's University Faculty of Pharmacy, Hiroshima, Japan – sequence: 27 givenname: Hitoshi surname: Katai fullname: Katai, Hitoshi organization: Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan – sequence: 28 givenname: Tadakazu surname: Shimoda fullname: Shimoda, Tadakazu organization: Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan – sequence: 29 givenname: Teruhiko surname: Yoshida fullname: Yoshida, Teruhiko email: tyoshida@ncc.go.jp organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan – sequence: 30 givenname: Yusuke surname: Nakamura fullname: Nakamura, Yusuke organization: Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan – sequence: 31 givenname: Setsuo surname: Hirohashi fullname: Hirohashi, Setsuo organization: National Cancer Center Research Institute, Tokyo, Japan – sequence: 32 givenname: Hiromi surname: Sakamoto fullname: Sakamoto, Hiromi organization: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21070779$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1086/502802 10.1093/genetics/164.4.1567 10.1038/sj.ejhg.5200677 10.1016/0197-2456(86)90046-2 10.1002/(SICI)1097-4644(19990701)74:1<11::AID-JCB2>3.0.CO;2-V 10.1007/PL00011681 10.1158/1078-0432.CCR-05-1197 10.1158/0008-5472.CAN-05-2474 10.1111/j.1440-1746.2008.05472.x 10.1023/A:1018573201347 10.1046/j.1365-2133.2003.05244.x 10.1074/jbc.M310538200 10.1006/bbrc.1999.0710 10.1126/science.1069424 10.1159/000086625 10.1002/(SICI)1097-0215(19980504)76:3<377::AID-IJC15>3.0.CO;2-8 10.1007/s004280100531 10.1016/S0021-9258(18)77254-2 10.1002/(SICI)1097-0215(19970529)71:5<741::AID-IJC9>3.0.CO;2-R 10.1007/s10552-009-9463-3 10.1002/gepi.210 10.1038/sj.bjc.6604617 10.1111/j.1432-1033.1994.00787.x 10.1016/S1535-6108(04)00020-0 10.1016/S0925-4439(99)00055-1 10.1038/nrc2761 10.1038/ng.152 10.1111/apm.1965.64.1.31 10.1086/302929 10.1023/A:1011379725811 10.1158/0008-5472.CAN-06-3063 10.5858/2004-128-765-DTITIA 10.1038/sj.onc.1206732 10.1016/j.tcb.2006.07.006 10.1371/journal.pone.0003312 |
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| Copyright | 2011 AGA Institute AGA Institute Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
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| Keywords | Stomach Cancer DGC Genome-Wide Association Study GWAS OR IGC PSCA Risk Genotype sig MUC1 por kb LD Cancer Prevention GC TR odds ratio kilobase prostate stem cell antigen diffuse-type gastric cancer linkage disequilibrium signet-ring cell carcinoma poorly differentiated adenocarcinoma mucin 1 gastric cancer tandem repeats intestinal-type gastric cancer |
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| References | Zhu, Zhang, Zhao (bib20) 2002; 23 Lauren (bib2) 1965; 64 (bib7) 2008; 40 Silva, Carvalho, Peixoto (bib9) 2001; 9 Nei (bib14) 1987 Bonkobara, Das, Takao (bib26) 2003; 148 Suwa, Hinoda, Makiguchi (bib29) 1998; 76 Taylor-Papadimitriou, Burchell, Miles (bib28) 1999; 1455 Huang, Chen, Liu (bib32) 2005; 65 Kufe (bib38) 2009; 9 Scheet, Stephens (bib17) 2006; 78 Gabriel, Schaffner, Nguyen (bib15) 2002; 296 Bacanu, Devlin, Roeder (bib19) 2000; 66 DerSimonian, Laird (bib16) 1986; 7 (bib13) 1998; 1 Li, Liu, Chen (bib22) 2003; 4 Armstrong, Saenz, Bornstein (bib25) 1999; 74 Falush, Stephens, Pritchard (bib18) 2003; 164 Raina, Kharbanda, Kufe (bib30) 2004; 279 Xu, Yuan, Sun (bib10) 2009; 35 Wei, Xu, Kufe (bib33) 2007; 67 Baruch, Hartmann, Zrihan-Licht (bib37) 1997; 71 Ren, Agata, Chen (bib31) 2004; 5 Gendler, Lancaster, Taylor-Papadimitriou (bib35) 1990; 265 Silva, Teixeira, David (bib40) 2002; 440 Adolph (bib24) 1999; 258 Hikita, Kosik, Clegg (bib39) 2008; 3 Rosai (bib6) 2004 Carvalho, Seruca, David (bib8) 1997; 14 Chiba, Marusawa, Seno (bib3) 2008; 23 Senapati, Sharma, Bafna (bib21) 2008; 23 Zrihan-Licht, Vos, Baruch (bib36) 1994; 224 Singh, Hollingsworth (bib34) 2006; 16 Gendler (bib27) 2001; 6 Brenner, Rothenbacher, Arndt (bib1) 2009; Volume 472 Schier, Wright (bib4) 2005; 69 Jia, Persson, Hou (bib11) 2010; 21 Henson, Dittus, Younes (bib5) 2004; 128 Ng, Loh, Teixeira (bib12) 2008; 99 Tsutsumida, Swanson, Singh (bib23) 2006; 15 Gendler (10.1053/j.gastro.2010.10.058_bib35) 1990; 265 Huang (10.1053/j.gastro.2010.10.058_bib32) 2005; 65 Kufe (10.1053/j.gastro.2010.10.058_bib38) 2009; 9 Gabriel (10.1053/j.gastro.2010.10.058_bib15) 2002; 296 Bacanu (10.1053/j.gastro.2010.10.058_bib19) 2000; 66 Lauren (10.1053/j.gastro.2010.10.058_bib2) 1965; 64 Hikita (10.1053/j.gastro.2010.10.058_bib39) 2008; 3 Gendler (10.1053/j.gastro.2010.10.058_bib27) 2001; 6 Raina (10.1053/j.gastro.2010.10.058_bib30) 2004; 279 Silva (10.1053/j.gastro.2010.10.058_bib40) 2002; 440 Taylor-Papadimitriou (10.1053/j.gastro.2010.10.058_bib28) 1999; 1455 DerSimonian (10.1053/j.gastro.2010.10.058_bib16) 1986; 7 Li (10.1053/j.gastro.2010.10.058_bib22) 2003; 4 Singh (10.1053/j.gastro.2010.10.058_bib34) 2006; 16 Henson (10.1053/j.gastro.2010.10.058_bib5) 2004; 128 Wei (10.1053/j.gastro.2010.10.058_bib33) 2007; 67 Jia (10.1053/j.gastro.2010.10.058_bib11) 2010; 21 (10.1053/j.gastro.2010.10.058_bib7) 2008; 40 Carvalho (10.1053/j.gastro.2010.10.058_bib8) 1997; 14 Baruch (10.1053/j.gastro.2010.10.058_bib37) 1997; 71 Adolph (10.1053/j.gastro.2010.10.058_bib24) 1999; 258 Chiba (10.1053/j.gastro.2010.10.058_bib3) 2008; 23 Xu (10.1053/j.gastro.2010.10.058_bib10) 2009; 35 Armstrong (10.1053/j.gastro.2010.10.058_bib25) 1999; 74 Zhu (10.1053/j.gastro.2010.10.058_bib20) 2002; 23 Tsutsumida (10.1053/j.gastro.2010.10.058_bib23) 2006; 15 Suwa (10.1053/j.gastro.2010.10.058_bib29) 1998; 76 Brenner (10.1053/j.gastro.2010.10.058_bib1) 2009; Volume 472 Falush (10.1053/j.gastro.2010.10.058_bib18) 2003; 164 Bonkobara (10.1053/j.gastro.2010.10.058_bib26) 2003; 148 Schier (10.1053/j.gastro.2010.10.058_bib4) 2005; 69 Silva (10.1053/j.gastro.2010.10.058_bib9) 2001; 9 Zrihan-Licht (10.1053/j.gastro.2010.10.058_bib36) 1994; 224 Ng (10.1053/j.gastro.2010.10.058_bib12) 2008; 99 Senapati (10.1053/j.gastro.2010.10.058_bib21) 2008; 23 Nei (10.1053/j.gastro.2010.10.058_bib14) 1987 Ren (10.1053/j.gastro.2010.10.058_bib31) 2004; 5 (10.1053/j.gastro.2010.10.058_bib13) 1998; 1 Rosai (10.1053/j.gastro.2010.10.058_bib6) 2004 Scheet (10.1053/j.gastro.2010.10.058_bib17) 2006; 78 |
| References_xml | – volume: 65 start-page: 10413 year: 2005 end-page: 10422 ident: bib32 article-title: MUC1 oncoprotein blocks glycogen synthase kinase 3β-mediated phosphorylation and degradation of β-catenin publication-title: Cancer Res – volume: 23 start-page: 1175 year: 2008 end-page: 1181 ident: bib3 article-title: Mechanism for gastric cancer development by publication-title: J Gastroenterol Hepatol – volume: 40 start-page: 730 year: 2008 end-page: 740 ident: bib7 article-title: Genetic variation in publication-title: Nat Genet – volume: 23 start-page: 181 year: 2002 end-page: 196 ident: bib20 article-title: Association mapping, using a mixture model for complex traits publication-title: Genet Epidemiol – volume: 99 start-page: 978 year: 2008 end-page: 985 ident: bib12 article-title: Genetic regulation of publication-title: Br J Cancer – volume: 224 start-page: 787 year: 1994 end-page: 795 ident: bib36 article-title: Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue publication-title: Eur J Biochem – volume: 9 start-page: 874 year: 2009 end-page: 885 ident: bib38 article-title: Mucins in cancer: function, prognosis and therapy publication-title: Nat Rev Cancer – volume: 9 start-page: 548 year: 2001 end-page: 552 ident: bib9 publication-title: Eur J Hum Genet – volume: 164 start-page: 1567 year: 2003 end-page: 1587 ident: bib18 article-title: Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies publication-title: Genetics – volume: 6 start-page: 339 year: 2001 end-page: 353 ident: bib27 article-title: MUC1, the renaissance molecule publication-title: J Mammary Gland Biol Neoplasia – volume: 128 start-page: 765 year: 2004 end-page: 770 ident: bib5 article-title: Differential trend in the intestinal and diffuse types of gastric carcinoma in the United States, 1973–2000—increase in the signet ring cell type publication-title: Arch Pathol Lab Med – volume: 14 start-page: 107 year: 1997 end-page: 111 ident: bib8 publication-title: Glycoconj J – volume: 15 start-page: 2976 year: 2006 end-page: 2987 ident: bib23 article-title: RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells publication-title: Clin Cancer Res – volume: 78 start-page: 629 year: 2006 end-page: 644 ident: bib17 article-title: A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase publication-title: Am J Hum Genet – volume: 1 start-page: 10 year: 1998 end-page: 24 ident: bib13 article-title: Japanese classification of gastric carcinoma publication-title: Gastric Cancer – volume: 69 start-page: 9 year: 2005 end-page: 13 ident: bib4 article-title: Stem cell relationships and the origin of gastrointestinal cancer publication-title: Oncology – volume: 74 start-page: 11 year: 1999 end-page: 22 ident: bib25 article-title: Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane publication-title: J Cell Biochem – volume: 279 start-page: 20607 year: 2004 end-page: 20612 ident: bib30 article-title: The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts publication-title: J Biol Chemi – volume: 5 start-page: 163 year: 2004 end-page: 175 ident: bib31 article-title: Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents publication-title: Cancer Cell – volume: 296 start-page: 2225 year: 2002 end-page: 2229 ident: bib15 article-title: The structure of haplotype blocks in human genome publication-title: Science – volume: 23 start-page: 1541 year: 2008 end-page: 1552 ident: bib21 article-title: The MUC gene family: their role in the diagnosis and prognosis of gastric cancer publication-title: Histol Histopathol – volume: 1455 start-page: 301 year: 1999 end-page: 313 ident: bib28 article-title: MUC1 and cancer publication-title: Biochim Biophys Acta – volume: 76 start-page: 377 year: 1998 end-page: 382 ident: bib29 article-title: Increased invasiveness of publication-title: Int J Cancer – volume: 71 start-page: 741 year: 1997 end-page: 749 ident: bib37 article-title: Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor-potentiating function publication-title: Int J Cancer – volume: 4 start-page: 6107 year: 2003 end-page: 6110 ident: bib22 article-title: Human DF3/MUC1 carcinoma-associated protein functions as an oncogene publication-title: Oncogene – volume: 21 start-page: 313 year: 2010 end-page: 321 ident: bib11 article-title: A comprehensive analysis of common genetic variation in publication-title: Cancer Causes Control – year: 1987 ident: bib14 publication-title: Molecular evolutionary genetics – volume: 7 start-page: 177 year: 1986 end-page: 188 ident: bib16 article-title: Meta-analysis in clinical trials publication-title: Control Clin Trials – volume: 440 start-page: 311 year: 2002 end-page: 317 ident: bib40 article-title: Mucins as key molecules for the classification of intestinal metaplasia of the stomach publication-title: Virchows Arch – volume: 3 start-page: e3312 year: 2008 ident: bib39 article-title: MUC1* mediates the growth of human pluripotent stem cells publication-title: PLoS One – volume: 64 start-page: 31 year: 1965 end-page: 49 ident: bib2 article-title: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma publication-title: Acta Pathol Microbiol Scand – volume: 67 start-page: 1853 year: 2007 end-page: 1858 ident: bib33 article-title: Human mucin 1 oncoprotein represses transcription of the publication-title: Cancer Res – volume: Volume 472 start-page: 467 year: 2009 end-page: 477 ident: bib1 article-title: Epidemiology of stomach cancer publication-title: Methods of molecular biology: cancer epidemiology – volume: 258 start-page: 792 year: 1999 end-page: 796 ident: bib24 article-title: Relative abundance of Thrombospondin 2 and Thrombospondin 3 mRNAs in human tissues publication-title: Biochem Biophys Res Commun – volume: 66 start-page: 1933 year: 2000 end-page: 1944 ident: bib19 article-title: The power of genomic control publication-title: Am J Hum Genet – volume: 16 start-page: 467 year: 2006 end-page: 476 ident: bib34 article-title: Cell surface-associated mucins in signal transduction publication-title: Trends Cell Biol – volume: 35 start-page: 1313 year: 2009 end-page: 1320 ident: bib10 article-title: Risk of gastric cancer is associated with the publication-title: Int J Oncol – volume: 148 start-page: 654 year: 2003 end-page: 664 ident: bib26 article-title: Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes publication-title: Br J Dermatol – year: 2004 ident: bib6 publication-title: Rosai and Ackerman's surgical pathology – volume: 265 start-page: 15286 year: 1990 end-page: 15293 ident: bib35 article-title: Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin publication-title: J Biol Chem – volume: 78 start-page: 629 year: 2006 ident: 10.1053/j.gastro.2010.10.058_bib17 article-title: A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase publication-title: Am J Hum Genet doi: 10.1086/502802 – volume: 164 start-page: 1567 year: 2003 ident: 10.1053/j.gastro.2010.10.058_bib18 article-title: Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies publication-title: Genetics doi: 10.1093/genetics/164.4.1567 – volume: 9 start-page: 548 year: 2001 ident: 10.1053/j.gastro.2010.10.058_bib9 article-title: MUC1 gene polymorphism in the gastric carcinogenesis pathway publication-title: Eur J Hum Genet doi: 10.1038/sj.ejhg.5200677 – volume: Volume 472 start-page: 467 year: 2009 ident: 10.1053/j.gastro.2010.10.058_bib1 article-title: Epidemiology of stomach cancer – volume: 7 start-page: 177 year: 1986 ident: 10.1053/j.gastro.2010.10.058_bib16 article-title: Meta-analysis in clinical trials publication-title: Control Clin Trials doi: 10.1016/0197-2456(86)90046-2 – volume: 74 start-page: 11 year: 1999 ident: 10.1053/j.gastro.2010.10.058_bib25 article-title: Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane publication-title: J Cell Biochem doi: 10.1002/(SICI)1097-4644(19990701)74:1<11::AID-JCB2>3.0.CO;2-V – volume: 1 start-page: 10 year: 1998 ident: 10.1053/j.gastro.2010.10.058_bib13 article-title: Japanese classification of gastric carcinoma publication-title: Gastric Cancer doi: 10.1007/PL00011681 – volume: 15 start-page: 2976 year: 2006 ident: 10.1053/j.gastro.2010.10.058_bib23 article-title: RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-05-1197 – volume: 65 start-page: 10413 year: 2005 ident: 10.1053/j.gastro.2010.10.058_bib32 article-title: MUC1 oncoprotein blocks glycogen synthase kinase 3β-mediated phosphorylation and degradation of β-catenin publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2474 – volume: 23 start-page: 1175 year: 2008 ident: 10.1053/j.gastro.2010.10.058_bib3 article-title: Mechanism for gastric cancer development by Helicobacter pylori infection publication-title: J Gastroenterol Hepatol doi: 10.1111/j.1440-1746.2008.05472.x – volume: 14 start-page: 107 year: 1997 ident: 10.1053/j.gastro.2010.10.058_bib8 article-title: MUC1 gene polymorphism and gastric cancer—an epidemiological study publication-title: Glycoconj J doi: 10.1023/A:1018573201347 – volume: 148 start-page: 654 year: 2003 ident: 10.1053/j.gastro.2010.10.058_bib26 article-title: Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes publication-title: Br J Dermatol doi: 10.1046/j.1365-2133.2003.05244.x – volume: 279 start-page: 20607 year: 2004 ident: 10.1053/j.gastro.2010.10.058_bib30 article-title: The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts publication-title: J Biol Chemi doi: 10.1074/jbc.M310538200 – volume: 258 start-page: 792 year: 1999 ident: 10.1053/j.gastro.2010.10.058_bib24 article-title: Relative abundance of Thrombospondin 2 and Thrombospondin 3 mRNAs in human tissues publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1999.0710 – volume: 296 start-page: 2225 year: 2002 ident: 10.1053/j.gastro.2010.10.058_bib15 article-title: The structure of haplotype blocks in human genome publication-title: Science doi: 10.1126/science.1069424 – volume: 69 start-page: 9 issue: Suppl 1 year: 2005 ident: 10.1053/j.gastro.2010.10.058_bib4 article-title: Stem cell relationships and the origin of gastrointestinal cancer publication-title: Oncology doi: 10.1159/000086625 – volume: 76 start-page: 377 year: 1998 ident: 10.1053/j.gastro.2010.10.058_bib29 article-title: Increased invasiveness of MUC1 cDNA-transfected human gastric cancer MKN74 cells publication-title: Int J Cancer doi: 10.1002/(SICI)1097-0215(19980504)76:3<377::AID-IJC15>3.0.CO;2-8 – volume: 440 start-page: 311 year: 2002 ident: 10.1053/j.gastro.2010.10.058_bib40 article-title: Mucins as key molecules for the classification of intestinal metaplasia of the stomach publication-title: Virchows Arch doi: 10.1007/s004280100531 – volume: 265 start-page: 15286 year: 1990 ident: 10.1053/j.gastro.2010.10.058_bib35 article-title: Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)77254-2 – volume: 71 start-page: 741 year: 1997 ident: 10.1053/j.gastro.2010.10.058_bib37 article-title: Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor-potentiating function publication-title: Int J Cancer doi: 10.1002/(SICI)1097-0215(19970529)71:5<741::AID-IJC9>3.0.CO;2-R – volume: 21 start-page: 313 year: 2010 ident: 10.1053/j.gastro.2010.10.058_bib11 article-title: A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer publication-title: Cancer Causes Control doi: 10.1007/s10552-009-9463-3 – volume: 23 start-page: 181 year: 2002 ident: 10.1053/j.gastro.2010.10.058_bib20 article-title: Association mapping, using a mixture model for complex traits publication-title: Genet Epidemiol doi: 10.1002/gepi.210 – volume: 99 start-page: 978 year: 2008 ident: 10.1053/j.gastro.2010.10.058_bib12 article-title: Genetic regulation of MUC1 alternative splicing in human tissues publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604617 – volume: 224 start-page: 787 year: 1994 ident: 10.1053/j.gastro.2010.10.058_bib36 article-title: Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1994.00787.x – volume: 5 start-page: 163 year: 2004 ident: 10.1053/j.gastro.2010.10.058_bib31 article-title: Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents publication-title: Cancer Cell doi: 10.1016/S1535-6108(04)00020-0 – volume: 1455 start-page: 301 year: 1999 ident: 10.1053/j.gastro.2010.10.058_bib28 article-title: MUC1 and cancer publication-title: Biochim Biophys Acta doi: 10.1016/S0925-4439(99)00055-1 – volume: 9 start-page: 874 year: 2009 ident: 10.1053/j.gastro.2010.10.058_bib38 article-title: Mucins in cancer: function, prognosis and therapy publication-title: Nat Rev Cancer doi: 10.1038/nrc2761 – year: 2004 ident: 10.1053/j.gastro.2010.10.058_bib6 – volume: 40 start-page: 730 year: 2008 ident: 10.1053/j.gastro.2010.10.058_bib7 article-title: Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer publication-title: Nat Genet doi: 10.1038/ng.152 – volume: 23 start-page: 1541 year: 2008 ident: 10.1053/j.gastro.2010.10.058_bib21 article-title: The MUC gene family: their role in the diagnosis and prognosis of gastric cancer publication-title: Histol Histopathol – volume: 64 start-page: 31 year: 1965 ident: 10.1053/j.gastro.2010.10.058_bib2 article-title: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma publication-title: Acta Pathol Microbiol Scand doi: 10.1111/apm.1965.64.1.31 – volume: 66 start-page: 1933 year: 2000 ident: 10.1053/j.gastro.2010.10.058_bib19 article-title: The power of genomic control publication-title: Am J Hum Genet doi: 10.1086/302929 – volume: 6 start-page: 339 year: 2001 ident: 10.1053/j.gastro.2010.10.058_bib27 article-title: MUC1, the renaissance molecule publication-title: J Mammary Gland Biol Neoplasia doi: 10.1023/A:1011379725811 – volume: 67 start-page: 1853 year: 2007 ident: 10.1053/j.gastro.2010.10.058_bib33 article-title: Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-3063 – volume: 128 start-page: 765 year: 2004 ident: 10.1053/j.gastro.2010.10.058_bib5 article-title: Differential trend in the intestinal and diffuse types of gastric carcinoma in the United States, 1973–2000—increase in the signet ring cell type publication-title: Arch Pathol Lab Med doi: 10.5858/2004-128-765-DTITIA – volume: 4 start-page: 6107 year: 2003 ident: 10.1053/j.gastro.2010.10.058_bib22 article-title: Human DF3/MUC1 carcinoma-associated protein functions as an oncogene publication-title: Oncogene doi: 10.1038/sj.onc.1206732 – volume: 35 start-page: 1313 year: 2009 ident: 10.1053/j.gastro.2010.10.058_bib10 article-title: Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism publication-title: Int J Oncol – volume: 16 start-page: 467 year: 2006 ident: 10.1053/j.gastro.2010.10.058_bib34 article-title: Cell surface-associated mucins in signal transduction publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2006.07.006 – year: 1987 ident: 10.1053/j.gastro.2010.10.058_bib14 – volume: 3 start-page: e3312 year: 2008 ident: 10.1053/j.gastro.2010.10.058_bib39 article-title: MUC1* mediates the growth of human pluripotent stem cells publication-title: PLoS One doi: 10.1371/journal.pone.0003312 |
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| Snippet | Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more influenced by genetic... Background & Aims Two major types of gastric cancer, intestinal and diffuse, develop through distinct mechanisms; the diffuse type is considered to be more... |
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| SubjectTerms | Asian Continental Ancestry Group - genetics Cancer Prevention Case-Control Studies Cell Line, Tumor Chromosomes, Human, Pair 1 Exons Female Gastroenterology and Hepatology Genetic Predisposition to Disease Genome-Wide Association Study Haplotypes Humans Japan - epidemiology Linkage Disequilibrium Logistic Models Male Middle Aged Mucin-1 - genetics Mucin-1 - metabolism Odds Ratio Phenotype Polymorphism, Single Nucleotide Promoter Regions, Genetic Republic of Korea - epidemiology Risk Assessment Risk Factors Risk Genotype Stomach Cancer Stomach Neoplasms - ethnology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transfection |
| Title | A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer |
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